Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2Y1 Gene

Aliases for OR2Y1 Gene

  • Olfactory Receptor Family 2 Subfamily Y Member 1 2 3 5
  • Olfactory Receptor OR5-2 3 4
  • Olfactory Receptor 2Y1 3 4
  • Olfactory Receptor, Family 2, Subfamily Y, Member 1 2
  • OR5-2 3
  • OR2Y1 5

External Ids for OR2Y1 Gene

Previous GeneCards Identifiers for OR2Y1 Gene

  • GC05U990148
  • GC05M180277
  • GC05M180098
  • GC05M180166
  • GC05M180740
  • GC05M180751
  • GC05M180760
  • GC05M180763
  • GC05M180786
  • GC05M180741
  • GC05M180746
  • GC05M180820
  • GC05M180866

Summaries for OR2Y1 Gene

Entrez Gene Summary for OR2Y1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2Y1 Gene

OR2Y1 (Olfactory Receptor Family 2 Subfamily Y Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2G3.

UniProtKB/Swiss-Prot Summary for OR2Y1 Gene

Gene Wiki entry for OR2Y1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2Y1 Gene

Genomics for OR2Y1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2Y1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J180350 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.9 +387.5 387461 3.5 ZNF600 POLR2A ZBTB10 MBD2 KLF9 SP2 ZNF316 SAFB DRAP1 ZBTB48 GFPT2 OR2Y1 BTNL9 HSALNG0047158 RF00017-4698 MAPK9
GH05J180784 Enhancer 1.1 ENCODE CraniofacialAtlas dbSUPER 10.8 -47.1 -47077 5.2 ZNF654 POLR2A ZIC2 CTCF REST TRIM22 ZNF217 SIN3A RAD21 RFX5 HSALNG0047194 lnc-MGAT1-1 MGAT1 ZFP62 OR2V2 OR2Y1 TRIM7-AS1 TRIM7 RACK1 BTNL3
GH05J180688 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE 11.5 +50.3 50346 3.3 EZH2 ZFX EGR2 RNF2 ZNF335 piR-30277 piR-34162 piR-52574 piR-47401 FLT4 OR2Y1 MGAT1 LINC02222 MK280269-055
GH05J180781 Enhancer 0.8 dbSUPER 10.8 -41.5 -41477 0.7 NCOR1 NFIC MNT NBN TAL1 SKIL NCOA2 HLTF STAT5A ZNF318 OR2V2 MGAT1 OR2Y1 CNOT6 HSALNG0047194 piR-61029-127
GH05J180790 Enhancer 0.7 ENCODE dbSUPER 10.8 -50.0 -50047 0.2 CTCF EBF1 RAD21 HNRNPL EGR2 ZNF143 GATAD2B piR-45468 MGAT1 OR2V2 OR2Y1 TRIM7-AS1 TRIM7 HSALNG0047194 lnc-MGAT1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2Y1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2Y1

Top Transcription factor binding sites by QIAGEN in the OR2Y1 gene promoter:
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA5
  • PPAR-gamma2
  • S8
  • SRF
  • SRF (504 AA)
  • TBP
  • TFIID

Genomic Locations for OR2Y1 Gene

Latest Assembly
chr5:180,739,042-180,740,099
(GRCh38/hg38)
Size:
1,058 bases
Orientation:
Minus strand

Previous Assembly
chr5:180,166,123-180,167,058
(GRCh37/hg19 by Entrez Gene)
Size:
936 bases
Orientation:
Minus strand

chr5:180,166,042-180,167,099
(GRCh37/hg19 by Ensembl)
Size:
1,058 bases
Orientation:
Minus strand

Genomic View for OR2Y1 Gene

Genes around OR2Y1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2Y1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2Y1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2Y1 Gene

Proteins for OR2Y1 Gene

  • Protein details for OR2Y1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV0-OR2Y1_HUMAN
    Recommended name:
    Olfactory receptor 2Y1
    Protein Accession:
    Q8NGV0
    Secondary Accessions:
    • B9EIP1
    • Q6IFB1
    • Q96R16

    Protein attributes for OR2Y1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34731 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2Y1 Gene

Post-translational modifications for OR2Y1 Gene

  • Glycosylation at Asn5 and Asn264
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2Y1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2Y1 Gene

Domains & Families for OR2Y1 Gene

Gene Families for OR2Y1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for OR2Y1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2Y1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR5-2 (OR2Y1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGV0

UniProtKB/Swiss-Prot:

OR2Y1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2Y1: view

Function for OR2Y1 Gene

Molecular function for OR2Y1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2Y1 Gene

Gene Ontology (GO) - Molecular Function for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2Y1: view

Phenotypes for OR2Y1 Gene

genes like me logo Genes that share phenotypes with OR2Y1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2Y1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2Y1 Gene

Localization for OR2Y1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2Y1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2Y1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2Y1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2Y1 Gene

Pathways & Interactions for OR2Y1 Gene

genes like me logo Genes that share pathways with OR2Y1: view

Pathways by source for OR2Y1 Gene

Interacting Proteins for OR2Y1 Gene

Gene Ontology (GO) - Biological Process for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2Y1: view

No data available for SIGNOR curated interactions for OR2Y1 Gene

Drugs & Compounds for OR2Y1 Gene

No Compound Related Data Available

Transcripts for OR2Y1 Gene

mRNA/cDNA for OR2Y1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2Y1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2Y1 Gene

No ASD Table

Relevant External Links for OR2Y1 Gene

GeneLoc Exon Structure for
OR2Y1

Expression for OR2Y1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2Y1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2Y1

SOURCE GeneReport for Unigene cluster for OR2Y1 Gene:

Hs.554719
genes like me logo Genes that share expression patterns with OR2Y1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2Y1 Gene

Orthologs for OR2Y1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2Y1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471778 29
  • 99.25 (n)
OR2Y1 30
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or2y1c 45 Olfr1386 29 16
  • 82.74 (n)
Or2y15 45 Olfr1387 30
  • 79 (a)
OneToOne
Or2y1 45 Olfr1385 16
Or2y10 45 Olfr1380
  • chr11:49,563,923-49,564,855
Or2y11 45 Olfr1381
  • chr11:49,551,749-49,552,681
Or2y12 45 Olfr1382
  • chr11:49,535,187-49,536,119
Or2y13 45 Olfr1383
  • chr11:49,523,725-49,524,657
Or2y14 45 Olfr1384
  • chr11:49,513,640-49,514,593
Or2y16 45 Olfr1388
  • chr11:49,443,853-49,444,785
Or2y17 45 Olfr1390
  • chr11:49,340,534-49,341,466
Or2y1b 45 Olfr10
  • chr11:49,317,548-49,318,480
Or2y1d 45 Olfr1389
  • chr11:49,430,478-49,431,410
Or2y1e 45 Olfr1391
  • chr11:49,327,413-49,328,345
Or2y1f 45 Olfr1392
  • chr11:49,293,323-49,294,255
Or2y1g 45 Olfr1393
  • chr11:49,280,150-49,281,082
Or2y6 45 Olfr1371
  • chr11:52,213,055-52,213,987
Or2y7 45 Olfr1372
  • chr11:52,155,249-52,156,283
Or2y8 45 Olfr1373
  • chr11:52,144,596-52,145,528
Or2y9-ps 45 Olfr1374-ps1
  • chr11:51,142,532-51,143,464
Rat
(Rattus norvegicus)
Mammalia Olr1394 29
  • 81.88 (n)
Cow
(Bos Taurus)
Mammalia OR2Y1 30
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 72 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 59 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia OR2Y1 30
  • 54 (a)
OneToOne
Species where no ortholog for OR2Y1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2Y1 Gene

ENSEMBL:
Gene Tree for OR2Y1 (if available)
TreeFam:
Gene Tree for OR2Y1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2Y1: view image
Alliance of Genome Resources:
Additional Orthologs for OR2Y1

Paralogs for OR2Y1 Gene

(437) SIMAP similar genes for OR2Y1 Gene using alignment to 1 proteins:

  • OR2Y1_HUMAN
genes like me logo Genes that share paralogs with OR2Y1: view

Variants for OR2Y1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2Y1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs10464105 -- p.Val200Leu
rs11954074 -- p.Val154Met
rs11960429 -- p.Arg128Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2Y1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2Y1 Gene

Variant ID Type Subtype PubMed ID
dgv10242n54 CNV gain 21841781
dgv5849n100 CNV gain 25217958
dgv5850n100 CNV gain 25217958
esv2759399 CNV gain 17122850
esv2762572 CNV gain 21179565
esv3607791 CNV gain 21293372
esv3890776 CNV gain 25118596
nsv1026417 CNV gain 25217958
nsv1034735 CNV gain 25217958
nsv1161322 CNV duplication 26073780
nsv517459 CNV gain 19592680
nsv830565 CNV loss 17160897

Variation tolerance for OR2Y1 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2Y1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2Y1
Leiden Open Variation Database (LOVD)
OR2Y1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2Y1 Gene

Disorders for OR2Y1 Gene

Additional Disease Information for OR2Y1

No disorders were found for OR2Y1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2Y1 Gene

Publications for OR2Y1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A … EUROSPAN Consortium (Obesity (Silver Spring, Md.) 2010) 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR2Y1 Gene

Sources for OR2Y1 Gene