Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2W5P Gene

Aliases for OR2W5P Gene

  • Olfactory Receptor Family 2 Subfamily W Member 5 Pseudogene 2 3 5
  • Olfactory Receptor, Family 2, Subfamily W, Member 5 2 3
  • OST722 2 3
  • OR2W5 3 4
  • Olfactory Receptor, Family 2, Subfamily W, Member 5 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 2 Subfamily W Member 5 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 2 Subfamily W Member 5 2
  • Putative Olfactory Receptor 2W5 Pseudogene 4
  • Putative Olfactory Receptor 2W5 3
  • Olfactory Receptor 2W5 3
  • OR2W5P 5

External Ids for OR2W5P Gene

Previous HGNC Symbols for OR2W5P Gene

  • OR2W5

Previous GeneCards Identifiers for OR2W5P Gene

  • GC00U990951

Summaries for OR2W5P Gene

Entrez Gene Summary for OR2W5P Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene has a coding sequence that is comparable in length to other olfactory receptor genes, but it should be noted that a frameshift is present in the 3' coding region that disrupts the 7-transmembrane domain structure in the protein. It is unclear if the protein can function as an olfactory receptor or if an alternate function is served. For this reason, this gene has also been interpreted to be a pseudogene. [provided by RefSeq, Jan 2010]

GeneCards Summary for OR2W5P Gene

OR2W5P (Olfactory Receptor Family 2 Subfamily W Member 5 Pseudogene) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory transduction.

UniProtKB/Swiss-Prot Summary for OR2W5P Gene

Additional gene information for OR2W5P Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2W5P Gene

Genomics for OR2W5P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2W5P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247486 Enhancer 0.6 Ensembl 250.7 -0.8 -792 0.6 BCLAF1 ZNF654 CTCF REST TRIM22 RAD21 SMC3 SMARCA5 MAX IKZF1 OR2W5P OR2B11 OR2C3 OR2G2 ZNF496 GCSAML-AS1 GCSAML HSALNG0012262 MK280269-007
GH01J247494 Enhancer 0.7 Ensembl ENCODE 0.4 +6.5 6508 3.2 NFIC BHLHE40 SPI1 LCORL NFIB CEBPB IKZF1 OR2B11 OR2G2 OR2C3 GCSAML-AS1 OR2G3 ENSG00000235749 ENSG00000236817 ZNF496 GCSAML OR2W5P
GH01J247475 Enhancer 0.6 Ensembl ENCODE 0.4 -11.4 -11445 1.5 IKZF1 NR2F1 SPI1 AFF1 GCSAML-AS1 OR2W5P OR2B11 GCSAML HSALNG0012262 MK280269-007
GH01J247472 Enhancer 0.3 Ensembl 0.4 -14.4 -14392 1.8 POU5F1 NANOG GCSAML-AS1 GCSAML OR2W5P OR2B11 HSALNG0012262 MK280269-007
GH01J247465 Enhancer 0.3 Ensembl 0.4 -22.2 -22192 1 ZNF512 ZNF496 OR2G3 GCSAML-AS1 OR2B11 OR2W5P GCSAML HSALNG0012262 MK280269-007
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2W5P on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2W5P

Genomic Locations for OR2W5P Gene

Latest Assembly
chr1:247,488,093-247,492,415
(GRCh38/hg38)
Size:
4,323 bases
Orientation:
Plus strand

Previous Assembly
chr1:247,651,395-247,655,711
(GRCh37/hg19 by Entrez Gene)
Size:
4,317 bases
Orientation:
Plus strand

chr1:247,654,370-247,655,710
(GRCh37/hg19 by Ensembl)
Size:
1,341 bases
Orientation:
Plus strand

Genomic View for OR2W5P Gene

Genes around OR2W5P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2W5P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2W5P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2W5P Gene

Proteins for OR2W5P Gene

  • Protein details for OR2W5P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFC9-OR2W5_HUMAN
    Recommended name:
    Putative olfactory receptor 2W5 pseudogene
    Protein Accession:
    A6NFC9
    Secondary Accessions:
    • B9EH85

    Protein attributes for OR2W5P Gene

    Size:
    320 amino acids
    Molecular mass:
    35528 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2W5P Gene

Post-translational modifications for OR2W5P Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OR2W5P Gene

Domains & Families for OR2W5P Gene

Gene Families for OR2W5P Gene

Protein Domains for OR2W5P Gene

Suggested Antigen Peptide Sequences for OR2W5P Gene

GenScript: Design optimal peptide antigens:
  • Putative olfactory receptor 2W5 (OR2W5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NFC9

UniProtKB/Swiss-Prot:

OR2W5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2W5P: view

Function for OR2W5P Gene

Molecular function for OR2W5P Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2W5P Gene

Gene Ontology (GO) - Molecular Function for OR2W5P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2W5P: view
genes like me logo Genes that share phenotypes with OR2W5P: view

Animal Models for research

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2W5P

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2W5P Gene

Localization for OR2W5P Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2W5P Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR2W5P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2W5P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR2W5P Gene

Pathways & Interactions for OR2W5P Gene

PathCards logo

SuperPathways for OR2W5P Gene

genes like me logo Genes that share pathways with OR2W5P: view

Pathways by source for OR2W5P Gene

Gene Ontology (GO) - Biological Process for OR2W5P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2W5P: view

No data available for Interacting Proteins and SIGNOR curated interactions for OR2W5P Gene

Drugs & Compounds for OR2W5P Gene

No Compound Related Data Available

Transcripts for OR2W5P Gene

mRNA/cDNA for OR2W5P Gene

3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2W5P

Alternative Splicing Database (ASD) splice patterns (SP) for OR2W5P Gene

No ASD Table

Relevant External Links for OR2W5P Gene

GeneLoc Exon Structure for
OR2W5P

Expression for OR2W5P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2W5P

SOURCE GeneReport for Unigene cluster for OR2W5P Gene:

Hs.591526
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2W5P Gene

Orthologs for OR2W5P Gene

Evolution for OR2W5P Gene

ENSEMBL:
Gene Tree for OR2W5P (if available)
TreeFam:
Gene Tree for OR2W5P (if available)
Alliance of Genome Resources:
Additional Orthologs for OR2W5P

No data available for Orthologs for OR2W5P Gene

Paralogs for OR2W5P Gene

No data available for Paralogs for OR2W5P Gene

Variants for OR2W5P Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2W5P Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2W5P Gene

Variant ID Type Subtype PubMed ID
dgv115n67 CNV loss 20364138
esv2675635 CNV deletion 23128226
esv2727818 CNV deletion 23290073
esv33129 CNV gain+loss 17666407
esv3589517 CNV loss 21293372
nsv1011097 CNV gain 25217958
nsv827764 CNV loss 20364138

Additional Variant Information for OR2W5P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2W5P
Leiden Open Variation Database (LOVD)
OR2W5P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for OR2W5P Gene

Disorders for OR2W5P Gene

Additional Disease Information for OR2W5P

No disorders were found for OR2W5P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2W5P Gene

Publications for OR2W5P Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 2 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR2W5P Gene

Sources for OR2W5P Gene