Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2W3 Gene

Aliases for OR2W3 Gene

  • Olfactory Receptor Family 2 Subfamily W Member 3 2 3 5
  • Olfactory Receptor OR1-49 3 4
  • Olfactory Receptor 2W3 3 4
  • Olfactory Receptor 2W8 3 4
  • OR2W3P 3 4
  • OR2W8P 3 4
  • OST718 2 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 3 2
  • OR2W3 5

External Ids for OR2W3 Gene

Previous HGNC Symbols for OR2W3 Gene

  • OR2W8P
  • OR2W3P

Previous GeneCards Identifiers for OR2W3 Gene

  • GC01U901042
  • GC01P244384
  • GC01P246125
  • GC01P248058
  • GC01P248031

Summaries for OR2W3 Gene

Entrez Gene Summary for OR2W3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2W3 Gene

OR2W3 (Olfactory Receptor Family 2 Subfamily W Member 3) is a Protein Coding gene. Diseases associated with OR2W3 include Adenosquamous Prostate Carcinoma and Retinitis Pigmentosa. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot Summary for OR2W3 Gene

Gene Wiki entry for OR2W3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2W3 Gene

Genomics for OR2W3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2W3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247854 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.5 -40.4 -40356 2.1 NCOR1 ZNF592 NFIC TBP ARNT NBN TAL1 ZNF316 NFE2 MYNN TRIM58 OR2T8 OR13G1 OR2W3 OR11L1
GH01J247844 Enhancer 0.5 Ensembl 6.6 -50.5 -50486 0.6 MAFG TCF12 RNF2 PKNOX1 HMBOX1 EMSY OR14A16 OR2W3 OR11L1 TRIM58
GH01J247637 Enhancer 0.3 Ensembl 4.8 -257.7 -257686 0.2 NR2F2 ENSG00000235749 OR2W3 ENSG00000236817 LOC102724446 piR-61391 OR2G3 OR13G1
GH01J247822 Enhancer 0.2 Ensembl 8.1 -73.1 -73086 0.2 OR14A16 TRIM58 OR2W3 HSD17B7P1 OR9H1P OR1C1
GH01J248654 Enhancer 0.2 dbSUPER 4.4 +760.5 760530 3.5 OR2T27 ENSG00000229255 OR2W3 OR14I1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2W3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2W3

Top Transcription factor binding sites by QIAGEN in the OR2W3 gene promoter:
  • Brachyury
  • FOXF2
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • RelA
  • USF1
  • Zic3

Genomic Locations for OR2W3 Gene

Latest Assembly
chr1:247,895,587-247,896,531
(GRCh38/hg38)
Size:
945 bases
Orientation:
Plus strand

Previous Assembly
chr1:248,058,889-248,059,833
(GRCh37/hg19 by Entrez Gene)
Size:
945 bases
Orientation:
Plus strand

chr1:248,031,277-248,060,449
(GRCh37/hg19 by Ensembl)
Size:
29,173 bases
Orientation:
Plus strand

Genomic View for OR2W3 Gene

Genes around OR2W3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2W3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2W3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2W3 Gene

Proteins for OR2W3 Gene

  • Protein details for OR2W3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3T1-OR2W3_HUMAN
    Recommended name:
    Olfactory receptor 2W3
    Protein Accession:
    Q7Z3T1
    Secondary Accessions:
    • Q6IF06
    • Q8NG86

    Protein attributes for OR2W3 Gene

    Size:
    314 amino acids
    Molecular mass:
    34789 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2W3 Gene

Post-translational modifications for OR2W3 Gene

  • Glycosylation at Asn5

Other Protein References for OR2W3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2W3 Gene

Domains & Families for OR2W3 Gene

Gene Families for OR2W3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2W3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2W3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 2, subfamily W, member 3 (B2RUT5_HUMAN)
  • Olfactory receptor OR1-49 (OR2W3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z3T1

UniProtKB/Swiss-Prot:

OR2W3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2W3: view

Function for OR2W3 Gene

Molecular function for OR2W3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2W3 Gene

Gene Ontology (GO) - Molecular Function for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2W3: view

Phenotypes for OR2W3 Gene

genes like me logo Genes that share phenotypes with OR2W3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2W3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2W3 Gene

Localization for OR2W3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2W3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2W3 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2W3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2W3 Gene

Pathways & Interactions for OR2W3 Gene

genes like me logo Genes that share pathways with OR2W3: view

Pathways by source for OR2W3 Gene

Interacting Proteins for OR2W3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000353516 Q7Z3T1-OR2W3_HUMAN for OR2W3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2W3: view

No data available for SIGNOR curated interactions for OR2W3 Gene

Drugs & Compounds for OR2W3 Gene

No Compound Related Data Available

Transcripts for OR2W3 Gene

mRNA/cDNA for OR2W3 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2W3

Alternative Splicing Database (ASD) splice patterns (SP) for OR2W3 Gene

No ASD Table

Relevant External Links for OR2W3 Gene

GeneLoc Exon Structure for
OR2W3

Expression for OR2W3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2W3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR2W3 Gene

This gene is overexpressed in Whole Blood (x29.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2W3

Evidence on tissue expression from TISSUES for OR2W3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with OR2W3: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2W3 Gene

Orthologs for OR2W3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2W3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR2W3 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 88 (a)
OneToMany
OR2W3 29
  • 84.52 (n)
-- 30
  • 84 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100684725 29
  • 85.09 (n)
OR2W3 30
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or2w3c 45 Olfr322 29 16 30
  • 82.32 (n)
OneToMany
Or2w3b 45 Olfr317 30
  • 80 (a)
OneToMany
Or2w3 45 Olfr179
  • chr11:58,665,537-58,666,541
Rat
(Rattus norvegicus)
Mammalia Olr1433 29
  • 82.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR2W3 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 70 (a)
OneToMany
Species where no ortholog for OR2W3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2W3 Gene

ENSEMBL:
Gene Tree for OR2W3 (if available)
TreeFam:
Gene Tree for OR2W3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2W3: view image
Alliance of Genome Resources:
Additional Orthologs for OR2W3

Paralogs for OR2W3 Gene

(455) SIMAP similar genes for OR2W3 Gene using alignment to 2 proteins:

  • OR2W3_HUMAN
  • B2RUT5_HUMAN

Pseudogenes.org Pseudogenes for OR2W3 Gene

genes like me logo Genes that share paralogs with OR2W3: view

Variants for OR2W3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2W3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs189993261 Uncertain Significance: not provided 247,896,010(+) C/Tp.Arg142Trp
NM_001001957.2(OR2W3):c.424C>T (p.Arg142Trp)
MISSENSE
rs61752499 Benign: not provided 247,895,776(+) G/A
NM_001001957.2(OR2W3):c.190G>A (p.Ala64Thr)
MISSENSE
rs10888267 -- p.Arg179Cys
rs11204545 -- p.Met272Lys
rs11204546 -- p.Met275Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2W3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2W3 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1008024 CNV gain 25217958
nsv1010087 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv508706 CNV deletion 20534489
nsv515858 CNV gain+loss 19592680
nsv5321 CNV deletion 18451855
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781
nsv549603 CNV loss 21841781

Variation tolerance for OR2W3 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.88; 99.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2W3 Gene

Human Gene Mutation Database (HGMD)
OR2W3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2W3
Leiden Open Variation Database (LOVD)
OR2W3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2W3 Gene

Disorders for OR2W3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR2W3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
adenosquamous prostate carcinoma
  • adenosquamous carcinoma of prostate
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards
Search OR2W3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR2W3

genes like me logo Genes that share disorders with OR2W3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2W3 Gene

Publications for OR2W3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4
  2. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. (PMID: 33097666) Huang J … An SS (Proceedings of the National Academy of Sciences of the United States of America 2020) 3
  3. OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol. (PMID: 27916748) Noe F … Krautwurst D (Chemical senses 2017) 3
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3
  5. Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations. (PMID: 28262088) Melroy-Greif WE … Ehlers CL (Twin research and human genetics : the official journal of the International Society for Twin Studies 2017) 3

Products for OR2W3 Gene

Sources for OR2W3 Gene