Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2W1 Gene

Aliases for OR2W1 Gene

  • Olfactory Receptor Family 2 Subfamily W Member 1 2 3 5
  • Hs6M1-15 2 3 4
  • Olfactory Receptor OR6-13 3 4
  • Olfactory Receptor 2W1 3 4
  • Olfactory Receptor, Family 2, Subfamily W, Member 1 2
  • OR2W1 5

External Ids for OR2W1 Gene

Previous GeneCards Identifiers for OR2W1 Gene

  • GC06M029069
  • GC06M028782
  • GC06M029119
  • GC06M029011
  • GC06Mo28942
  • GC06M029059
  • GC06M029060
  • GC06M029078
  • GC06M029080
  • GC06M029048
  • GC06M029056
  • GC06M029061
  • GC06M029062
  • GC06M029064
  • GC06M029065
  • GC06M029066
  • GC06M029067
  • GC06M029072
  • GC06M029073

Summaries for OR2W1 Gene

Entrez Gene Summary for OR2W1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2W1 Gene

OR2W1 (Olfactory Receptor Family 2 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2G3.

UniProtKB/Swiss-Prot Summary for OR2W1 Gene

Gene Wiki entry for OR2W1 Gene

Additional gene information for OR2W1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2W1 Gene

Genomics for OR2W1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2W1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J028814 Enhancer 0.8 FANTOM5 4.2 +230.9 230862 0.1 PRDM10 ZNF629 IKZF1 ZNF692 PRDM1 ZSCAN4 POLR2A PATZ1 ZNF501 EZH2 ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3 OR2B3
GH06J029226 Enhancer 0.2 Ensembl 10.7 -181.1 -181061 0.6 TRIM27 OR2W1 OR14J1 MICD ENSG00000197171 LOC101929006 OR2G1P OR2J2
GH06J029467 Enhancer 0.2 FANTOM5 7.4 -422.5 -422459 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06J029017 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 0.3 +28.2 28191 1.6 GATAD2A CTCF PRDM10 ZNF629 IKZF1 NFKBIZ ZNF692 JUND DDX20 ZNF143 piR-30449-154 piR-56367 TRIM27 ZKSCAN4 ZNF603P OR2B8P ZFP57 HLA-A ENSG00000230521 ZKSCAN8
GH06J029011 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 0.3 +33.9 33869 0.7 PRDM10 RFX1 JUND PRDM1 POLR2A DPF2 HDAC1 ZNF341 MGA ZBTB20 ZKSCAN8 ZKSCAN3 ZSCAN9 HLA-F-AS1 ZSCAN12 ZKSCAN4 LINC01556 HLA-W piR-30449-154 ZNF311
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2W1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2W1

Top Transcription factor binding sites by QIAGEN in the OR2W1 gene promoter:
  • AML1a
  • ER-alpha
  • Evi-1
  • NF-kappaB
  • NF-kappaB1
  • Nkx3-1
  • Nkx3-1 v1
  • RFX1

Genomic Locations for OR2W1 Gene

Genomic Locations for OR2W1 Gene
chr6:29,044,213-29,045,240
(GRCh38/hg38)
Size:
1,028 bases
Orientation:
Minus strand
chr6:29,011,990-29,013,017
(GRCh37/hg19)
Size:
1,028 bases
Orientation:
Minus strand

Genomic View for OR2W1 Gene

Genes around OR2W1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2W1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2W1 Gene

  • Protein details for OR2W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3N9-OR2W1_HUMAN
    Recommended name:
    Olfactory receptor 2W1
    Protein Accession:
    Q9Y3N9
    Secondary Accessions:
    • B0S7Y5
    • Q5JNZ1
    • Q6IEU0
    • Q96R17
    • Q9GZL0
    • Q9GZL1

    Protein attributes for OR2W1 Gene

    Size:
    320 amino acids
    Molecular mass:
    36101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2W1 Gene

Post-translational modifications for OR2W1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2W1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2W1 Gene

Domains & Families for OR2W1 Gene

Gene Families for OR2W1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2W1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR2W1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR6-13 (OR2W1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3N9

UniProtKB/Swiss-Prot:

OR2W1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2W1: view

Function for OR2W1 Gene

Molecular function for OR2W1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily W,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2W1 Gene

Gene Ontology (GO) - Molecular Function for OR2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2W1: view
genes like me logo Genes that share phenotypes with OR2W1: view

Animal Model Products

CRISPR Products

miRNA for OR2W1 Gene

miRTarBase miRNAs that target OR2W1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2W1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2W1 Gene

Localization for OR2W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2W1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2W1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2W1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2W1 Gene

Pathways & Interactions for OR2W1 Gene

genes like me logo Genes that share pathways with OR2W1: view

Pathways by source for OR2W1 Gene

1 KEGG pathway for OR2W1 Gene

Interacting Proteins for OR2W1 Gene

Gene Ontology (GO) - Biological Process for OR2W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2W1: view

No data available for SIGNOR curated interactions for OR2W1 Gene

Drugs & Compounds for OR2W1 Gene

No Compound Related Data Available

Transcripts for OR2W1 Gene

mRNA/cDNA for OR2W1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2W1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2W1 Gene

No ASD Table

Relevant External Links for OR2W1 Gene

GeneLoc Exon Structure for
OR2W1

Expression for OR2W1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2W1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2W1 Gene

This gene is overexpressed in Testis (x43.1) and Liver (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2W1

SOURCE GeneReport for Unigene cluster for OR2W1 Gene:

Hs.553526
genes like me logo Genes that share expression patterns with OR2W1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2W1 Gene

Orthologs for OR2W1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2W1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471927 30
  • 98.96 (n)
OR2W1 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR2W1 30
  • 89.69 (n)
-- 31
  • 88 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr1662 30
  • 85.49 (n)
Mouse
(Mus musculus)
Mammalia Or2w1 46 Olfr263 30 17 31
  • 85.49 (n)
OneToMany
Olfr1369-ps1 31
  • 85 (a)
OneToMany
Or2w1b 46 Olfr1369
  • chr13:21,115,694-21,116,644
Dog
(Canis familiaris)
Mammalia OR2W1 31
  • 82 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR2W1 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 63 (a)
OneToMany
Species where no ortholog for OR2W1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2W1 Gene

ENSEMBL:
Gene Tree for OR2W1 (if available)
TreeFam:
Gene Tree for OR2W1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2W1: view image

Paralogs for OR2W1 Gene

(444) SIMAP similar genes for OR2W1 Gene using alignment to 1 proteins:

  • OR2W1_HUMAN
genes like me logo Genes that share paralogs with OR2W1: view

Variants for OR2W1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2W1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs34892006 - p.Met81Val
rs35771565 - p.Asp296Asn

Additional dbSNP identifiers (rs#s) for OR2W1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2W1 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074388 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv601216 CNV gain 21841781
nsv830622 CNV gain 17160897
nsv830623 CNV gain 17160897

Variation tolerance for OR2W1 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.40; 90.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2W1 Gene

Human Gene Mutation Database (HGMD)
OR2W1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2W1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2W1 Gene

Disorders for OR2W1 Gene

Additional Disease Information for OR2W1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for OR2W1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2W1 Gene

Publications for OR2W1 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

Products for OR2W1 Gene

Sources for OR2W1 Gene