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Aliases for OR2V2 Gene

Aliases for OR2V2 Gene

  • Olfactory Receptor Family 2 Subfamily V Member 2 2 3 5
  • Olfactory Receptor OR5-3 3 4
  • Olfactory Receptor 2V3 3 4
  • OR2V3 3 4
  • Olfactory Receptor, Family 2, Subfamily V, Member 3 3
  • Olfactory Receptor, Family 2, Subfamily V, Member 2 2
  • Olfactory Receptor 2V2 3
  • OST713 3

External Ids for OR2V2 Gene

Previous HGNC Symbols for OR2V2 Gene

  • OR2V3

Previous GeneCards Identifiers for OR2V2 Gene

  • GC13U990069
  • GC05P180691
  • GC05P180514
  • GC05P180581

Summaries for OR2V2 Gene

Entrez Gene Summary for OR2V2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2V2 Gene

OR2V2 (Olfactory Receptor Family 2 Subfamily V Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2V1.

UniProtKB/Swiss-Prot for OR2V2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2V2 Gene

Additional gene information for OR2V2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2V2 Gene

Genomics for OR2V2 Gene

GeneHancer (GH) Regulatory Elements for OR2V2 Gene

Promoters and enhancers for OR2V2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J181221 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 14.7 +75.7 75666 4.4 CLOCK ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PIR62653 PIR33457 TRIM41 TRK-CTT2-3 TRV-CAC1-5 MIR4638 ENSG00000233937 TRIM52 RACK1 CNOT6
GH05J180493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 -652.2 -652220 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 ZNF2 CNOT6 HNRNPH1 MAML1 MRNIP ENSG00000233937 TRIM52 ZFP62 RUFY1 RACK1 LOC100420514
GH05J180351 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 14.6 -794.6 -794588 2.4 PKNOX1 KLF17 SIN3A BMI1 ZNF335 GLIS2 ZNF213 SMARCA5 SP3 ZBTB11 GFPT2 LOC100420514 OR2AI1P LOC100419853 LOC646227 OR2V2 ENSG00000250674 ENSG00000253652 LOC100128762 LOC100289470
GH05J181172 Enhancer 1.4 Ensembl ENCODE dbSUPER 14.9 +26.1 26118 1.8 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF213 E2F8 ZNF207 FOS KLF13 PIR55575 TRL-AAG1-3 TRV-CAC1-4 TRIM52 ZFP62 ENSG00000233937 CNOT6 ENSG00000248514 OR2V2 ENSG00000250765
GH05J180784 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -360.6 -360600 5.6 NFIB SIN3A RAD21 RFX5 CHAMP1 ZNF143 EGR2 SMARCA5 ZNF654 REST GC05M180785 MGAT1 ZFP62 OR2V2 OR2Y1 ENSG00000250900 TRIM7 RACK1 BTNL3 GC05P181086
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2V2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2V2 gene promoter:
  • Pax-6
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • GATA-1
  • Evi-1
  • c-Myc
  • Max

Genomic Locations for OR2V2 Gene

Genomic Locations for OR2V2 Gene
11,700 bases
Plus strand
948 bases
Plus strand

Genomic View for OR2V2 Gene

Genes around OR2V2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2V2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2V2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2V2 Gene

Proteins for OR2V2 Gene

  • Protein details for OR2V2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2V2
    Protein Accession:
    Secondary Accessions:
    • Q6IFL6
    • Q8NGV1

    Protein attributes for OR2V2 Gene

    315 amino acids
    Molecular mass:
    35339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2V2 Gene

Post-translational modifications for OR2V2 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2V2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2V2 Gene

Domains & Families for OR2V2 Gene

Gene Families for OR2V2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2V2 Gene

Suggested Antigen Peptide Sequences for OR2V2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2V2: view

Function for OR2V2 Gene

Molecular function for OR2V2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2V2: view
genes like me logo Genes that share phenotypes with OR2V2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2V2 Gene

Localization for OR2V2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2V2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2V2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2V2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2V2 Gene

Pathways & Interactions for OR2V2 Gene

genes like me logo Genes that share pathways with OR2V2: view

Pathways by source for OR2V2 Gene

Interacting Proteins for OR2V2 Gene

Gene Ontology (GO) - Biological Process for OR2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2V2: view

No data available for SIGNOR curated interactions for OR2V2 Gene

Drugs & Compounds for OR2V2 Gene

No Compound Related Data Available

Transcripts for OR2V2 Gene

mRNA/cDNA for OR2V2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2V2 Gene

Olfactory receptor, family 2, subfamily V, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2V2 Gene

No ASD Table

Relevant External Links for OR2V2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2V2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2V2 Gene

Protein differential expression in normal tissues from HIPED for OR2V2 Gene

This gene is overexpressed in Urine (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2V2 Gene

Protein tissue co-expression partners for OR2V2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2V2 Gene:


SOURCE GeneReport for Unigene cluster for OR2V2 Gene:

genes like me logo Genes that share expression patterns with OR2V2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2V2 Gene

Orthologs for OR2V2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2V2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC471781 33
  • 99.37 (n)
OR2V2 34
  • 99 (a)
(Bos Taurus)
Mammalia OR2V2 33
  • 87.2 (n)
-- 34
  • 87 (a)
-- 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Olr1384 33
  • 85.58 (n)
(Mus musculus)
Mammalia Or2v2 51 Olfr1396 16 34 33
  • 85.03 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 74 (a)
(Canis familiaris)
Mammalia -- 34
  • 57 (a)
Species where no ortholog for OR2V2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2V2 Gene

Gene Tree for OR2V2 (if available)
Gene Tree for OR2V2 (if available)
Evolutionary constrained regions (ECRs) for OR2V2: view image

Paralogs for OR2V2 Gene

(447) SIMAP similar genes for OR2V2 Gene using alignment to 1 proteins:

  • OR2V2_HUMAN Pseudogenes for OR2V2 Gene

genes like me logo Genes that share paralogs with OR2V2: view

Variants for OR2V2 Gene

Sequence variations from dbSNP and Humsavar for OR2V2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000576614 -- 181,155,843(+) G/T coding_sequence_variant, missense_variant
rs1001354536 -- 181,155,767(+) C/G coding_sequence_variant, synonymous_variant
rs1001491414 -- 181,156,034(+) C/T downstream_transcript_variant
rs1002349003 -- 181,154,446(+) T/C upstream_transcript_variant
rs1002906543 -- 181,154,538(+) A/C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2V2 Gene

Variant ID Type Subtype PubMed ID
dgv10251n54 CNV gain 21841781
dgv5861n100 CNV gain 25217958
dgv5862n100 CNV gain 25217958
dgv5863n100 CNV gain 25217958
dgv735n27 CNV gain 19166990
esv2436663 OTHER inversion 19546169
esv2763893 CNV gain 21179565
esv3607812 CNV gain 21293372
esv3607816 CNV gain 21293372
esv8228 OTHER inversion 19470904
nsv1032581 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv471062 CNV gain 18288195
nsv5163 CNV deletion 18451855
nsv520110 CNV gain 19592680
nsv600729 CNV gain 21841781
nsv600730 CNV loss 21841781
nsv830567 CNV loss 17160897

Variation tolerance for OR2V2 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2V2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2V2 Gene

Disorders for OR2V2 Gene

Additional Disease Information for OR2V2

No disorders were found for OR2V2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2V2 Gene

Publications for OR2V2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2V2 Gene

Sources for OR2V2 Gene

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