Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2V1 Gene

Aliases for OR2V1 Gene

  • Olfactory Receptor Family 2 Subfamily V Member 1 2 3 5
  • Olfactory Receptor 2V1 3 4
  • OST265 2 3
  • Olfactory Receptor, Family 2, Subfamily V, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily V, Member 1 2
  • OR2V1P 3
  • OR2V1 5

External Ids for OR2V1 Gene

Previous HGNC Symbols for OR2V1 Gene

  • OR2V1P

Previous GeneCards Identifiers for OR2V1 Gene

  • GC05U900491
  • GC05M180483
  • GC05M180552

Summaries for OR2V1 Gene

Entrez Gene Summary for OR2V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2V1 Gene

OR2V1 (Olfactory Receptor Family 2 Subfamily V Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2V2.

UniProtKB/Swiss-Prot Summary for OR2V1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2V1 Gene

Genomics for OR2V1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2V1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J181107 Enhancer 0.8 Ensembl 13.1 +23.2 23215 0.6 NCOR1 IKZF1 NFIC ARNT NBN TAL1 ZFP91 MYNN PRDM10 STAT5A OR2V1 OR2V2 RPL13P10 LOC729707 TRV-CAC1-3 BTNL9
GH05J181109 Enhancer 0.3 Ensembl ENCODE 13.1 +21.5 21469 1 OR2V1 OR2V2 RPL13P10 LOC729707 TRV-CAC1-3 BTNL9
GH05J181133 Enhancer 1 Ensembl ENCODE 0.7 -2.6 -2632 1.6 IKZF1 ZNF592 NFIC FEZF1 TRIM25 ZNF316 NFE2 PTBP1 JUND THRAP3 ZFP62 TRIM52 CNOT6 OR2V1 OR2V2
GH05J181099 Promoter 0.9 Ensembl 0.3 +31.2 31168 1.2 ZNF600 ATF2 ZNF341 SIN3B SAFB SKIL SMARCA4 SP1 NRF1 ZNF18 FOXO1B TRL-AAG1-2 ENSG00000248560 TRL-AAG1-1 OR2V1 BTNL9
GH05J181101 Promoter 0.8 Ensembl 0.3 +28.6 28568 3.6 ZNF600 KLF9 SAFB SKIL SP1 NRF1 IKZF1 ZNF366 ZBTB8A ATF1 FOXO1B TRL-AAG1-2 TRV-CAC1-3 piR-33164-009 ENSG00000248560 LOC729707 OR2V1 BTNL9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2V1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2V1

Genomic Locations for OR2V1 Gene

Latest Assembly
chr5:181,123,122-181,131,169
(GRCh38/hg38)
Size:
8,048 bases
Orientation:
Minus strand

Previous Assembly
chr5:180,550,122-180,558,169
(GRCh37/hg19 by Entrez Gene)
Size:
8,048 bases
Orientation:
Minus strand

chr5:180,551,357-180,552,304
(GRCh37/hg19 by Ensembl)
Size:
948 bases
Orientation:
Minus strand

Genomic View for OR2V1 Gene

Genes around OR2V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2V1 Gene

Proteins for OR2V1 Gene

  • Protein details for OR2V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHB1-OR2V1_HUMAN
    Recommended name:
    Olfactory receptor 2V1
    Protein Accession:
    Q8NHB1

    Protein attributes for OR2V1 Gene

    Size:
    315 amino acids
    Molecular mass:
    34857 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05724.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for OR2V1 Gene

Post-translational modifications for OR2V1 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2V1 Gene

No data available for DME Specific Peptides for OR2V1 Gene

Domains & Families for OR2V1 Gene

Gene Families for OR2V1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2V1 Gene

Suggested Antigen Peptide Sequences for OR2V1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 2V1 (OR2V1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHB1

UniProtKB/Swiss-Prot:

OR2V1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2V1: view

Function for OR2V1 Gene

Molecular function for OR2V1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2V1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2V1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2V1 Gene

Localization for OR2V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2V1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2V1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2V1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2V1 Gene

Pathways & Interactions for OR2V1 Gene

genes like me logo Genes that share pathways with OR2V1: view

Pathways by source for OR2V1 Gene

Interacting Proteins for OR2V1 Gene

Gene Ontology (GO) - Biological Process for OR2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2V1: view

No data available for SIGNOR curated interactions for OR2V1 Gene

Drugs & Compounds for OR2V1 Gene

No Compound Related Data Available

Transcripts for OR2V1 Gene

mRNA/cDNA for OR2V1 Gene

1 REFSEQ mRNAs :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2V1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2V1 Gene

No ASD Table

Relevant External Links for OR2V1 Gene

GeneLoc Exon Structure for
OR2V1

Expression for OR2V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2V1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2V1 Gene

This gene is overexpressed in Fallopian Tube (x17.9), Thyroid (x7.3), and Cervix - Endocervix (x5.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2V1

SOURCE GeneReport for Unigene cluster for OR2V1 Gene:

Hs.742585
genes like me logo Genes that share expression patterns with OR2V1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2V1 Gene

Orthologs for OR2V1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2V1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471780 29
  • 98.62 (n)
OR2V1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC491671 29
  • 89.1 (n)
OR2V1 30
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or2v1 45 Olfr56 29 16 30
  • 87.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1386 29
  • 86.98 (n)
Cow
(Bos Taurus)
Mammalia LOC511586 29
  • 86.77 (n)
OR2V1 30
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 78 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
Species where no ortholog for OR2V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2V1 Gene

ENSEMBL:
Gene Tree for OR2V1 (if available)
TreeFam:
Gene Tree for OR2V1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2V1: view image
Alliance of Genome Resources:
Additional Orthologs for OR2V1

Paralogs for OR2V1 Gene

(448) SIMAP similar genes for OR2V1 Gene using alignment to 1 proteins:

  • OR2V1_HUMAN
genes like me logo Genes that share paralogs with OR2V1: view

Variants for OR2V1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2V1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2V1 Gene

Variant ID Type Subtype PubMed ID
dgv10251n54 CNV gain 21841781
dgv365n21 CNV loss 19592680
dgv5861n100 CNV gain 25217958
dgv735n27 CNV gain 19166990
esv2436663 OTHER inversion 19546169
esv3607812 CNV gain 21293372
esv8228 OTHER inversion 19470904
nsv1024929 CNV loss 25217958
nsv1032581 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv471062 CNV gain 18288195
nsv600712 CNV gain 21841781
nsv830567 CNV loss 17160897
nsv964991 CNV duplication 23825009

Variation tolerance for OR2V1 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2V1
Leiden Open Variation Database (LOVD)
OR2V1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2V1 Gene

Disorders for OR2V1 Gene

Additional Disease Information for OR2V1

No disorders were found for OR2V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2V1 Gene

Publications for OR2V1 Gene

  1. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4

Products for OR2V1 Gene

Sources for OR2V1 Gene