Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2T6 Gene

Aliases for OR2T6 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 6 2 3 5
  • OST703 2 3 4
  • Olfactory Receptor 2T6 3 4
  • Olfactory Receptor 2T9 3 4
  • OR2T6P 3 4
  • OR2T9 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 6 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily T, Member 6 2
  • Seven Transmembrane Helix Receptor 3
  • OR2T6 5

External Ids for OR2T6 Gene

Previous HGNC Symbols for OR2T6 Gene

  • OR2T6P
  • OR2T9

Previous GeneCards Identifiers for OR2T6 Gene

  • GC01P245449
  • GC01U901106
  • GC01P244878
  • GC01P246617
  • GC01P248550
  • GC01P248387

Summaries for OR2T6 Gene

Entrez Gene Summary for OR2T6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T6 Gene

OR2T6 (Olfactory Receptor Family 2 Subfamily T Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot Summary for OR2T6 Gene

Gene Wiki entry for OR2T6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2T6 Gene

Genomics for OR2T6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2T6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248471 Enhancer 0.5 FANTOM5 10.5 +96.0 96006 0.4 ZNF207 MAFG HDGF TARDBP OR2T3 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2T6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2T6

Top Transcription factor binding sites by QIAGEN in the OR2T6 gene promoter:
  • E47
  • LCR-F1
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-alpha
  • Tal-1
  • YY1

Genomic Locations for OR2T6 Gene

Latest Assembly
chr1:248,375,746-248,391,811
(GRCh38/hg38)
Size:
16,066 bases
Orientation:
Plus strand

Previous Assembly
chr1:248,539,047-248,555,112
(GRCh37/hg19 by Entrez Gene)
Size:
16,066 bases
Orientation:
Plus strand

chr1:248,550,910-248,551,836
(GRCh37/hg19 by Ensembl)
Size:
927 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr1(ALT_REF_LOCI_1):23,720-40,126 (+)
  • chr1(ALT_REF_LOCI_2):23,719-40,125 (+)

Genomic View for OR2T6 Gene

Genes around OR2T6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T6 Gene

Proteins for OR2T6 Gene

  • Protein details for OR2T6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHC8-OR2T6_HUMAN
    Recommended name:
    Olfactory receptor 2T6
    Protein Accession:
    Q8NHC8
    Secondary Accessions:
    • A6NE36

    Protein attributes for OR2T6 Gene

    Size:
    308 amino acids
    Molecular mass:
    34765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05705.1; Type=Miscellaneous discrepancy; Note=Hybrid of two separate genomic loci.; Evidence={ECO:0000305};

neXtProt entry for OR2T6 Gene

Post-translational modifications for OR2T6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T6 Gene

Domains & Families for OR2T6 Gene

Gene Families for OR2T6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2T6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 2T9 (OR2T6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHC8

UniProtKB/Swiss-Prot:

OR2T6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T6: view

Function for OR2T6 Gene

Molecular function for OR2T6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2T6: view
genes like me logo Genes that share phenotypes with OR2T6: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2T6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T6 Gene

Localization for OR2T6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2T6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T6 Gene

Pathways & Interactions for OR2T6 Gene

genes like me logo Genes that share pathways with OR2T6: view

Pathways by source for OR2T6 Gene

Interacting Proteins for OR2T6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000347965 Q8NHC8-OR2T6_HUMAN for OR2T6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR2T6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T6: view

No data available for SIGNOR curated interactions for OR2T6 Gene

Drugs & Compounds for OR2T6 Gene

No Compound Related Data Available

Transcripts for OR2T6 Gene

mRNA/cDNA for OR2T6 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2T6

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T6 Gene

No ASD Table

Relevant External Links for OR2T6 Gene

GeneLoc Exon Structure for
OR2T6

Expression for OR2T6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2T6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2T6

SOURCE GeneReport for Unigene cluster for OR2T6 Gene:

Hs.626884
genes like me logo Genes that share expression patterns with OR2T6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T6 Gene

Orthologs for OR2T6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469771 29
  • 99.03 (n)
OR2T6 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR2T6 29 30
  • 83.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC607872 29
  • 82.58 (n)
OR2T6 30
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or2t6 45 Olfr720 29 16 30
  • 82.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1607 29
  • 81.47 (n)
Species where no ortholog for OR2T6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2T6 Gene

ENSEMBL:
Gene Tree for OR2T6 (if available)
TreeFam:
Gene Tree for OR2T6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2T6: view image
Alliance of Genome Resources:
Additional Orthologs for OR2T6

Paralogs for OR2T6 Gene

(450) SIMAP similar genes for OR2T6 Gene using alignment to 1 proteins:

  • OR2T6_HUMAN
genes like me logo Genes that share paralogs with OR2T6: view

Variants for OR2T6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2T6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs6587467 -- p.Cys23Gly
rs6693032 -- p.Thr57Asn
rs6701129 -- p.Leu159Pro
rs7417616 -- p.Asn21Asp
rs954475 -- p.Ser243Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2T6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2T6 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv613n100 CNV loss 25217958
dgv906n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv3589550 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv428357 CNV loss 18775914
nsv511035 OTHER complex 20534489
nsv515858 CNV gain+loss 19592680
nsv5332 CNV deletion 18451855
nsv549603 CNV loss 21841781
nsv549630 CNV loss 21841781

Variation tolerance for OR2T6 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.10; 96.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T6
Leiden Open Variation Database (LOVD)
OR2T6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T6 Gene

Disorders for OR2T6 Gene

Additional Disease Information for OR2T6

No disorders were found for OR2T6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T6 Gene

Publications for OR2T6 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  3. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M … Conrads TP (Electrophoresis 2004) 3
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3

Products for OR2T6 Gene

Sources for OR2T6 Gene