Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2T5 Gene

Aliases for OR2T5 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 5 2 3 5
  • Olfactory Receptor OR1-62 3 4
  • Olfactory Receptor 2T5 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 5 2
  • OR1-62 3
  • OR2T5 5

External Ids for OR2T5 Gene

Previous GeneCards Identifiers for OR2T5 Gene

  • GC01U990403
  • GC01P245550
  • GC01P244977
  • GC01P246718
  • GC01P248651

Summaries for OR2T5 Gene

Entrez Gene Summary for OR2T5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T5 Gene

OR2T5 (Olfactory Receptor Family 2 Subfamily T Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T29.

UniProtKB/Swiss-Prot Summary for OR2T5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2T5 Gene

Genomics for OR2T5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2T5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248482 Enhancer 0.6 ENCODE 0.4 -6.0 -6034 0.7 ZNF592 TRIM22 SMARCA5 HDGF KLF5 IKZF1 ZNF687 IKZF2 NBN ARNT LOC105373279 ENSG00000229255 ENSG00000224521 OR2T3 OR2T5
GH01J248477 Enhancer 0.3 Ensembl 0.4 -9.5 -9488 3.4 TARDBP ENSG00000229255 ENSG00000224521 GCSAML-AS1 LOC105373279 OR2T3 OR2T5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2T5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2T5

Top Transcription factor binding sites by QIAGEN in the OR2T5 gene promoter:
  • AML1a
  • c-Myc
  • E47
  • En-1
  • Max
  • POU3F1
  • SRF
  • SRF (504 AA)
  • USF1

Genomic Locations for OR2T5 Gene

Latest Assembly
chr1:248,488,589-248,491,113
(GRCh38/hg38)
Size:
2,525 bases
Orientation:
Plus strand

Previous Assembly
chr1:248,651,890-248,654,414
(GRCh37/hg19 by Entrez Gene)
Size:
2,525 bases
Orientation:
Plus strand

chr1:248,651,885-248,652,898
(GRCh37/hg19 by Ensembl)
Size:
1,014 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr1(ALT_REF_LOCI_1):142,629-145,153 (+)
  • chr1(ALT_REF_LOCI_2):139,007-141,531 (+)

Genomic View for OR2T5 Gene

Genes around OR2T5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T5 Gene

Proteins for OR2T5 Gene

  • Protein details for OR2T5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEZ7-OR2T5_HUMAN
    Recommended name:
    Olfactory receptor 2T5
    Protein Accession:
    Q6IEZ7
    Secondary Accessions:
    • B9EIN2

    Protein attributes for OR2T5 Gene

    Size:
    315 amino acids
    Molecular mass:
    35595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T5 Gene

Post-translational modifications for OR2T5 Gene

  • Glycosylation at Asn3 and Asn9
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T5 Gene

Domains & Families for OR2T5 Gene

Gene Families for OR2T5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2T5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 2, subfamily T, member 5 (B9EIN2_HUMAN)
  • Olfactory receptor OR1-62 (OR2T5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IEZ7

UniProtKB/Swiss-Prot:

OR2T5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T5: view

Function for OR2T5 Gene

Molecular function for OR2T5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2T5: view
genes like me logo Genes that share phenotypes with OR2T5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2T5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T5 Gene

Localization for OR2T5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T5 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OR2T5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2T5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T5 Gene

Pathways & Interactions for OR2T5 Gene

genes like me logo Genes that share pathways with OR2T5: view

Pathways by source for OR2T5 Gene

Interacting Proteins for OR2T5 Gene

Gene Ontology (GO) - Biological Process for OR2T5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T5: view

No data available for SIGNOR curated interactions for OR2T5 Gene

Drugs & Compounds for OR2T5 Gene

No Compound Related Data Available

Transcripts for OR2T5 Gene

mRNA/cDNA for OR2T5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2T5

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T5 Gene

No ASD Table

Relevant External Links for OR2T5 Gene

GeneLoc Exon Structure for
OR2T5

Expression for OR2T5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2T5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2T5

SOURCE GeneReport for Unigene cluster for OR2T5 Gene:

Hs.553808
genes like me logo Genes that share expression patterns with OR2T5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T5 Gene

Orthologs for OR2T5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469776 29
  • 97.88 (n)
-- 30
  • 95 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC788323 29
  • 85.81 (n)
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia LOC482243 29
  • 84.55 (n)
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 80 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1424 29
  • 82.73 (n)
Mouse
(Mus musculus)
Mammalia Olfr328 30
  • 77 (a)
ManyToMany
Olfr330 30
  • 77 (a)
ManyToMany
Olfr224 30
  • 75 (a)
ManyToMany
Olfr325 30
  • 75 (a)
ManyToMany
Olfr331 30
  • 75 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 74 (a)
OneToMany
Species where no ortholog for OR2T5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2T5 Gene

ENSEMBL:
Gene Tree for OR2T5 (if available)
TreeFam:
Gene Tree for OR2T5 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR2T5

Paralogs for OR2T5 Gene

(452) SIMAP similar genes for OR2T5 Gene using alignment to 2 proteins:

  • OR2T5_HUMAN
  • B9EIN2_HUMAN
genes like me logo Genes that share paralogs with OR2T5: view

Variants for OR2T5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2T5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1770043 Benign: not specified 248,488,626(+) A/Gp.Lys13Arg
NM_001004697.2(OR2T5):c.38A>G (p.Lys13Arg)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2T5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2T5 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv323n106 OTHER inversion 24896259
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv613n100 CNV loss 25217958
dgv615n100 CNV loss 25217958
dgv616n100 CNV gain 25217958
dgv617n100 CNV gain 25217958
dgv618n100 CNV loss 25217958
dgv906n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv2760083 CNV gain+loss 21179565
esv3575950 CNV gain 25503493
esv3578547 CNV loss 25503493
esv3891415 CNV gain 25118596
esv7998 OTHER inversion 19470904
nsv1001474 CNV gain 25217958
nsv1001494 CNV gain 25217958
nsv1003091 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1009036 CNV gain+loss 25217958
nsv1010059 CNV loss 25217958
nsv1013273 CNV gain 25217958
nsv1079019 OTHER inversion 25765185
nsv1150779 OTHER inversion 26484159
nsv1160483 CNV duplication 26073780
nsv428357 CNV loss 18775914
nsv515858 CNV gain+loss 19592680
nsv5354 CNV deletion 18451855
nsv549603 CNV loss 21841781
nsv549630 CNV loss 21841781
nsv549641 CNV gain 21841781
nsv7193 OTHER inversion 18451855
nsv821623 CNV loss 15273396
nsv945472 CNV duplication 23825009

Variation tolerance for OR2T5 Gene

Gene Damage Index Score: 7.30; 81.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T5
Leiden Open Variation Database (LOVD)
OR2T5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T5 Gene

Disorders for OR2T5 Gene

Additional Disease Information for OR2T5

No disorders were found for OR2T5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T5 Gene

Publications for OR2T5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. (PMID: 30745168) Wang B … Liu Y (EBioMedicine 2019) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR2T5 Gene

Sources for OR2T5 Gene