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Aliases for OR2T4 Gene

Aliases for OR2T4 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 4 2 3 5
  • Olfactory Receptor OR1-60 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 4 2
  • Olfactory Receptor 2T4 3
  • OR1-60 3
  • OR2T4Q 3

External Ids for OR2T4 Gene

Previous GeneCards Identifiers for OR2T4 Gene

  • GC01U990404
  • GC01P245423
  • GC01P244850
  • GC01P246591
  • GC01P248524

Summaries for OR2T4 Gene

Entrez Gene Summary for OR2T4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T4 Gene

OR2T4 (Olfactory Receptor Family 2 Subfamily T Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T29.

UniProtKB/Swiss-Prot for OR2T4 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T4 Gene

Additional gene information for OR2T4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T4 Gene

Genomics for OR2T4 Gene

GeneHancer (GH) Regulatory Elements for OR2T4 Gene

Promoters and enhancers for OR2T4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248471 Enhancer 0.5 FANTOM5 6.6 +110.2 110171 0.4 HDGF TARDBP ZNF207 MAFG OR2T3 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2T4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2T4 gene promoter:
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • AML1a
  • deltaCREB
  • CREB
  • SRF

Genomic Locations for OR2T4 Gene

Genomic Locations for OR2T4 Gene
1,047 bases
Plus strand
1,047 bases
Plus strand

Genomic View for OR2T4 Gene

Genes around OR2T4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T4 Gene

Proteins for OR2T4 Gene

  • Protein details for OR2T4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2T4
    Protein Accession:
    Secondary Accessions:
    • Q6IEZ8

    Protein attributes for OR2T4 Gene

    348 amino acids
    Molecular mass:
    39414 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05842.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2T4 Gene

Post-translational modifications for OR2T4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR2T4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T4 Gene

Domains & Families for OR2T4 Gene

Gene Families for OR2T4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T4 Gene

Suggested Antigen Peptide Sequences for OR2T4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T4: view

Function for OR2T4 Gene

Molecular function for OR2T4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T4: view
genes like me logo Genes that share phenotypes with OR2T4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T4 Gene

Localization for OR2T4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T4 Gene

Pathways & Interactions for OR2T4 Gene

genes like me logo Genes that share pathways with OR2T4: view

Pathways by source for OR2T4 Gene

Gene Ontology (GO) - Biological Process for OR2T4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T4: view

No data available for SIGNOR curated interactions for OR2T4 Gene

Drugs & Compounds for OR2T4 Gene

No Compound Related Data Available

Transcripts for OR2T4 Gene

mRNA/cDNA for OR2T4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2T4 Gene

Olfactory receptor, family 2, subfamily T, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T4 Gene

No ASD Table

Relevant External Links for OR2T4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2T4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2T4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T4 Gene:


SOURCE GeneReport for Unigene cluster for OR2T4 Gene:

genes like me logo Genes that share expression patterns with OR2T4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T4 Gene

Orthologs for OR2T4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469770 33
  • 98.47 (n)
OR2T4 34
  • 97 (a)
(Canis familiaris)
Mammalia LOC482236 33
  • 84.9 (n)
-- 34
  • 81 (a)
-- 34
  • 80 (a)
(Bos Taurus)
Mammalia LOC615281 33
  • 84.62 (n)
-- 34
  • 81 (a)
-- 34
  • 79 (a)
(Mus musculus)
Mammalia Olfr330 34 33
  • 83.07 (n)
Olfr328 34
  • 76 (a)
Olfr331 16 34
  • 75 (a)
Olfr224 34
  • 75 (a)
Olfr325 34
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
Species where no ortholog for OR2T4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T4 Gene

Gene Tree for OR2T4 (if available)
Gene Tree for OR2T4 (if available)
Evolutionary constrained regions (ECRs) for OR2T4: view image

Paralogs for OR2T4 Gene

(437) SIMAP similar genes for OR2T4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T4: view

Variants for OR2T4 Gene

Sequence variations from dbSNP and Humsavar for OR2T4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000480574 -- 248,359,978(+) C/G upstream_transcript_variant
rs1001434985 -- 248,362,002(+) G/A coding_sequence_variant, missense_variant
rs1005818378 -- 248,361,291(+) A/G upstream_transcript_variant
rs1006157036 -- 248,359,815(+) C/A upstream_transcript_variant
rs1007002629 -- 248,360,068(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2T4 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv613n100 CNV loss 25217958
dgv906n54 CNV gain 21841781
esv2728151 CNV deletion 23290073
esv2728162 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv3589547 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv1127074 CNV deletion 24896259
nsv1135761 CNV deletion 24896259
nsv428357 CNV loss 18775914
nsv515858 CNV gain+loss 19592680
nsv5332 CNV deletion 18451855
nsv549603 CNV loss 21841781
nsv549626 CNV loss 21841781
nsv549630 CNV loss 21841781
nsv9125 CNV gain 18304495
nsv945466 CNV duplication 23825009

Variation tolerance for OR2T4 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.67; 99.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T4 Gene

Disorders for OR2T4 Gene

Additional Disease Information for OR2T4

No disorders were found for OR2T4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T4 Gene

Publications for OR2T4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2T4 Gene

Sources for OR2T4 Gene

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