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Aliases for OR2T33 Gene

Aliases for OR2T33 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 33 2 3 5
  • Olfactory Receptor OR1-56 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor, Family 2, Subfamily T, Member 33 2
  • Olfactory Receptor 2T33 3
  • OR1-56 3
  • OR2T32 3

External Ids for OR2T33 Gene

Previous GeneCards Identifiers for OR2T33 Gene

  • GC01M245334
  • GC01M244762
  • GC01M246502
  • GC01M248436

Summaries for OR2T33 Gene

Entrez Gene Summary for OR2T33 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T33 Gene

OR2T33 (Olfactory Receptor Family 2 Subfamily T Member 33) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T12.

UniProtKB/Swiss-Prot for OR2T33 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T33 Gene

Additional gene information for OR2T33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T33 Gene

Genomics for OR2T33 Gene

GeneHancer (GH) Regulatory Elements for OR2T33 Gene

Promoters and enhancers for OR2T33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248471 Enhancer 0.5 FANTOM5 10.7 -193.8 -193776 0.4 HDGF TARDBP ZNF207 MAFG OR2T3 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2T33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2T33 gene promoter:
  • AML1a
  • PPAR-alpha
  • HNF-4alpha1
  • COMP1
  • PPAR-gamma2
  • PPAR-gamma1
  • GATA-2
  • CUTL1
  • TBP

Genomic Locations for OR2T33 Gene

Genomic Locations for OR2T33 Gene
8,060 bases
Minus strand
1,066 bases
Minus strand

Genomic View for OR2T33 Gene

Genes around OR2T33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T33 Gene

Proteins for OR2T33 Gene

  • Protein details for OR2T33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2T33
    Protein Accession:
    Secondary Accessions:
    • B2RNN0

    Protein attributes for OR2T33 Gene

    320 amino acids
    Molecular mass:
    35876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T33 Gene

Post-translational modifications for OR2T33 Gene

  • Glycosylation at Asn17
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T33 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T33 Gene

Domains & Families for OR2T33 Gene

Gene Families for OR2T33 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T33 Gene

Suggested Antigen Peptide Sequences for OR2T33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T33: view

Function for OR2T33 Gene

Molecular function for OR2T33 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2T33 Gene

Gene Ontology (GO) - Molecular Function for OR2T33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T33: view
genes like me logo Genes that share phenotypes with OR2T33: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T33 Gene

Localization for OR2T33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T33 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T33 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T33 Gene

Pathways & Interactions for OR2T33 Gene

genes like me logo Genes that share pathways with OR2T33: view

Pathways by source for OR2T33 Gene

Interacting Proteins for OR2T33 Gene

Gene Ontology (GO) - Biological Process for OR2T33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T33: view

No data available for SIGNOR curated interactions for OR2T33 Gene

Drugs & Compounds for OR2T33 Gene

No Compound Related Data Available

Transcripts for OR2T33 Gene

mRNA/cDNA for OR2T33 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2T33 Gene

Olfactory receptor, family 2, subfamily T, member 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T33 Gene

No ASD Table

Relevant External Links for OR2T33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2T33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2T33 Gene

mRNA differential expression in normal tissues according to GTEx for OR2T33 Gene

This gene is overexpressed in Testis (x7.3), Thyroid (x5.7), and Cervix - Endocervix (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR2T33 Gene:


SOURCE GeneReport for Unigene cluster for OR2T33 Gene:

genes like me logo Genes that share expression patterns with OR2T33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T33 Gene

Orthologs for OR2T33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T33 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100685834 33
  • 81.3 (n)
-- 34
  • 78 (a)
(Rattus norvegicus)
Mammalia Olr1454 33
  • 76.43 (n)
(Bos Taurus)
Mammalia -- 34
  • 74 (a)
-- 34
  • 73 (a)
-- 34
  • 70 (a)
(Mus musculus)
Mammalia Olfr314 34
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
Species where no ortholog for OR2T33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T33 Gene

Gene Tree for OR2T33 (if available)
Gene Tree for OR2T33 (if available)
Evolutionary constrained regions (ECRs) for OR2T33: view image

Paralogs for OR2T33 Gene

(452) SIMAP similar genes for OR2T33 Gene using alignment to 1 proteins:

  • O2T33_HUMAN Pseudogenes for OR2T33 Gene

genes like me logo Genes that share paralogs with OR2T33: view

Variants for OR2T33 Gene

Sequence variations from dbSNP and Humsavar for OR2T33 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs200877558 benign, not specified 248,273,336(-) A/G coding_sequence_variant, missense_variant
rs1002350253 -- 248,273,105(-) G/A coding_sequence_variant, missense_variant
rs1002381457 -- 248,273,714(-) A/C coding_sequence_variant, missense_variant
rs1002718260 -- 248,275,135(-) T/C upstream_transcript_variant
rs1004319955 -- 248,275,575(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2T33 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv611n100 CNV gain 25217958
dgv612n100 CNV loss 25217958
dgv613n100 CNV loss 25217958
dgv904n54 CNV gain 21841781
dgv905n54 CNV gain 21841781
esv2728006 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549626 CNV loss 21841781
nsv549630 CNV loss 21841781
nsv9103 CNV loss 18304495
nsv945463 CNV duplication 23825009

Variation tolerance for OR2T33 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T33 Gene

Disorders for OR2T33 Gene

Additional Disease Information for OR2T33

No disorders were found for OR2T33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T33 Gene

Publications for OR2T33 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2T33 Gene

Sources for OR2T33 Gene

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