Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2T29 Gene

Aliases for OR2T29 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 29 2 3 5
  • Olfactory Receptor 2T29 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 29 2

External Ids for OR2T29 Gene

Previous GeneCards Identifiers for OR2T29 Gene

  • GC01M245659
  • GC01M245047
  • GC01M246788
  • GC01M248721

Summaries for OR2T29 Gene

Entrez Gene Summary for OR2T29 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T29 Gene

OR2T29 (Olfactory Receptor Family 2 Subfamily T Member 29) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T5.

UniProtKB/Swiss-Prot Summary for OR2T29 Gene

Additional gene information for OR2T29 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2T29 Gene

Genomics for OR2T29 Gene

GeneHancer (GH) Regulatory Elements for OR2T29 Gene


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2T29

Top Transcription factor binding sites by QIAGEN in the OR2T29 gene promoter:
  • AML1a
  • c-Myc
  • E47
  • En-1
  • Max
  • POU3F1
  • SRF
  • SRF (504 AA)
  • USF1

Genomic Locations for OR2T29 Gene

Genomic Locations for OR2T29 Gene
chr1:248,556,912-248,562,772
(GRCh38/hg38)
Size:
5,861 bases
Orientation:
Minus strand
chr1:248,721,784-248,722,797
(GRCh37/hg19)
Size:
1,014 bases
Orientation:
Minus strand

Genomic View for OR2T29 Gene

Genes around OR2T29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T29 Gene

Proteins for OR2T29 Gene

  • Protein details for OR2T29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH02-O2T29_HUMAN
    Recommended name:
    Olfactory receptor 2T29
    Protein Accession:
    Q8NH02

    Protein attributes for OR2T29 Gene

    Size:
    315 amino acids
    Molecular mass:
    35595 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05840.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2T29 Gene

Post-translational modifications for OR2T29 Gene

  • Glycosylation at Asn3 and Asn9
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T29 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T29 Gene

Domains & Families for OR2T29 Gene

Gene Families for OR2T29 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T29 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR2T29 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 2T29 (O2T29_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH02

UniProtKB/Swiss-Prot:

O2T29_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T29: view

Function for OR2T29 Gene

Molecular function for OR2T29 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2T29: view
genes like me logo Genes that share phenotypes with OR2T29: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T29 Gene

Localization for OR2T29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T29 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T29 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2T29: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T29 Gene

Pathways & Interactions for OR2T29 Gene

genes like me logo Genes that share pathways with OR2T29: view

Pathways by source for OR2T29 Gene

Interacting Proteins for OR2T29 Gene

;

Gene Ontology (GO) - Biological Process for OR2T29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T29: view

No data available for SIGNOR curated interactions for OR2T29 Gene

Drugs & Compounds for OR2T29 Gene

No Compound Related Data Available

Transcripts for OR2T29 Gene

mRNA/cDNA for OR2T29 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T29 Gene

No ASD Table

Relevant External Links for OR2T29 Gene

GeneLoc Exon Structure for
OR2T29

Expression for OR2T29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2T29 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2T29

SOURCE GeneReport for Unigene cluster for OR2T29 Gene:

Hs.553707
genes like me logo Genes that share expression patterns with OR2T29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T29 Gene

Orthologs for OR2T29 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469776 30
  • 98.1 (n)
-- 31
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC788323 30
  • 85.81 (n)
-- 31
  • 83 (a)
ManyToMany
-- 31
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC482243 30
  • 84.76 (n)
-- 31
  • 83 (a)
ManyToMany
-- 31
  • 80 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1424 30
  • 82.73 (n)
mouse
(Mus musculus)
Mammalia Or2t47 47 Olfr328 31
  • 77 (a)
ManyToMany
Or2t48 47 Olfr330 31
  • 77 (a)
ManyToMany
Or2t46 47 Olfr325 31
  • 75 (a)
ManyToMany
Or2t43 47 Olfr224 31
  • 75 (a)
ManyToMany
Or2t49 47 Olfr331 31
  • 75 (a)
ManyToMany
Or2t29 47 Olfr329
  • chr11:58,542,521-58,543,474
Or2t50-ps 47 Olfr326-ps1
  • chr11:58,574,910-58,575,352
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
Species where no ortholog for OR2T29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T29 Gene

ENSEMBL:
Gene Tree for OR2T29 (if available)
TreeFam:
Gene Tree for OR2T29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2T29: view image

Paralogs for OR2T29 Gene

(447) SIMAP similar genes for OR2T29 Gene using alignment to 1 proteins:

  • O2T29_HUMAN
genes like me logo Genes that share paralogs with OR2T29: view

Variants for OR2T29 Gene

Additional dbSNP identifiers (rs#s) for OR2T29 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2T29 Gene

Variant ID Type Subtype PubMed ID
dgv165e212 CNV gain 25503493
dgv166e212 CNV loss 25503493
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv29n111 CNV deletion 26073780
dgv323n106 OTHER inversion 24896259
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv616n100 CNV gain 25217958
dgv617n100 CNV gain 25217958
dgv618n100 CNV loss 25217958
dgv619n100 CNV gain 25217958
dgv620n100 CNV loss 25217958
dgv621n100 CNV gain+loss 25217958
dgv622n100 CNV loss 25217958
dgv623n100 CNV loss 25217958
dgv624n100 CNV gain+loss 25217958
dgv625n100 CNV gain 25217958
dgv626n100 CNV loss 25217958
dgv906n54 CNV gain 21841781
dgv909n54 CNV loss 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv2760083 CNV gain+loss 21179565
esv2763780 CNV loss 21179565
esv3891415 CNV gain 25118596
esv7998 OTHER inversion 19470904
nsv1003091 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1010059 CNV loss 25217958
nsv1013273 CNV gain 25217958
nsv1079019 OTHER inversion 25765185
nsv1150779 OTHER inversion 26484159
nsv1160483 CNV duplication 26073780
nsv428357 CNV loss 18775914
nsv469750 CNV loss 16826518
nsv515858 CNV gain+loss 19592680
nsv5365 CNV deletion 18451855
nsv549603 CNV loss 21841781
nsv549641 CNV gain 21841781
nsv7193 OTHER inversion 18451855
nsv821623 CNV loss 15273396
nsv827820 CNV gain 20364138
nsv945474 CNV duplication 23825009

Variation tolerance for OR2T29 Gene

Gene Damage Index Score: 16.58; 97.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2T29 Gene

Disorders for OR2T29 Gene

Additional Disease Information for OR2T29

No disorders were found for OR2T29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T29 Gene

Publications for OR2T29 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  2. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. (PMID: 30745168) Wang B … Liu Y (EBioMedicine 2019) 3

Products for OR2T29 Gene

Sources for OR2T29 Gene