Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2T1 Gene

Aliases for OR2T1 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 1 2 3 5
  • OR1-25 2 3 4
  • Olfactory Receptor OR1-61 3 4
  • Olfactory Receptor 1-25 3 4
  • Olfactory Receptor 2T1 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 1 2
  • OR2T1 5

External Ids for OR2T1 Gene

Previous GeneCards Identifiers for OR2T1 Gene

  • GC01U990267
  • GC01M243796
  • GC01P244617
  • GC01P245467
  • GC01P244876
  • GC01P246635
  • GC01P248569

Summaries for OR2T1 Gene

Entrez Gene Summary for OR2T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T1 Gene

OR2T1 (Olfactory Receptor Family 2 Subfamily T Member 1) is a Protein Coding gene. Diseases associated with OR2T1 include Retinal Arteries, Tortuosity Of and Pseudobulbar Palsy. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T6.

UniProtKB/Swiss-Prot Summary for OR2T1 Gene

Gene Wiki entry for OR2T1 Gene

Additional gene information for OR2T1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2T1 Gene

Genomics for OR2T1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2T1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248686 Enhancer 0.8 Ensembl ENCODE 11.1 +284.0 284006 0.4 CTCF RAD21 TRIM22 EED BCLAF1 SMC3 IKZF1 EBF1 ATF2 TBX21 OR14I1 OR2T1 LYPD9P ENSG00000286015
GH01J248807 Enhancer 0.8 ENCODE 10.2 +404.2 404249 0.2 CTCF JUND FOXA1 ZNF143 REST RAD21 IRF2 TRIM22 SOX6 NRF1 HSALNG0012312 RNU6-1205P OR2T1 SH3BP5L DPY19L4P1 LYPD8
GH01J248471 Enhancer 0.5 FANTOM5 17.4 +68.7 68704 0.4 MAFG HDGF ZNF207 TARDBP OR2T3 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3
GH01J248803 Enhancer 0.8 ENCODE 10.2 +402.3 402274 3.5 ZNF512 IKZF2 CTCF POLR2A TRIM22 EED ARID3A RAD21 DPF2 RELB SH3BP5L RNU6-1205P OR2T1 HSALNG0012312 DPY19L4P1 LYPD8
GH01J248688 Enhancer 0.6 Ensembl 10.9 +285.5 285453 0.2 IKZF2 TRIM22 RELB RUNX3 GATAD2B ARNT NBN IKZF1 TARDBP CREM OR2T1 RNU6-1205P ENSG00000229255 OR14I1 LYPD9P ENSG00000286015
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2T1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2T1

Top Transcription factor binding sites by QIAGEN in the OR2T1 gene promoter:
  • E47
  • LCR-F1
  • Pbx1a
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • Sox9
  • Tal-1
  • Zic3

Genomic Locations for OR2T1 Gene

Genomic Locations for OR2T1 Gene
chr1:248,403,048-248,408,020
(GRCh38/hg38)
Size:
4,973 bases
Orientation:
Plus strand
chr1:248,569,296-248,570,405
(GRCh37/hg19)
Size:
1,110 bases
Orientation:
Plus strand

Genomic View for OR2T1 Gene

Genes around OR2T1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T1 Gene

Proteins for OR2T1 Gene

  • Protein details for OR2T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43869-OR2T1_HUMAN
    Recommended name:
    Olfactory receptor 2T1
    Protein Accession:
    O43869
    Secondary Accessions:
    • Q6IEZ9

    Protein attributes for OR2T1 Gene

    Size:
    369 amino acids
    Molecular mass:
    41996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T1 Gene

Post-translational modifications for OR2T1 Gene

  • Glycosylation at Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T1 Gene

Domains & Families for OR2T1 Gene

Gene Families for OR2T1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR2T1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-61 (OR2T1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43869

UniProtKB/Swiss-Prot:

OR2T1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T1: view

Function for OR2T1 Gene

Molecular function for OR2T1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily T,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2T1: view
genes like me logo Genes that share phenotypes with OR2T1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2T1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T1 Gene

Localization for OR2T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2T1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T1 Gene

Pathways & Interactions for OR2T1 Gene

genes like me logo Genes that share pathways with OR2T1: view

Pathways by source for OR2T1 Gene

1 KEGG pathway for OR2T1 Gene

Interacting Proteins for OR2T1 Gene

Gene Ontology (GO) - Biological Process for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T1: view

No data available for SIGNOR curated interactions for OR2T1 Gene

Drugs & Compounds for OR2T1 Gene

No Compound Related Data Available

Transcripts for OR2T1 Gene

mRNA/cDNA for OR2T1 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2T1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T1 Gene

No ASD Table

Relevant External Links for OR2T1 Gene

GeneLoc Exon Structure for
OR2T1

Expression for OR2T1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2T1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2T1

SOURCE GeneReport for Unigene cluster for OR2T1 Gene:

Hs.626885
genes like me logo Genes that share expression patterns with OR2T1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T1 Gene

Orthologs for OR2T1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100609051 30
  • 99.46 (n)
OR2T1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR2T1 30
  • 87.21 (n)
Cow
(Bos Taurus)
Mammalia OR2T1 30 31
  • 86.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR2T1 31
  • 85 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1606 30
  • 83.86 (n)
Mouse
(Mus musculus)
Mammalia Or2t1 46 Olfr31 30 17 31
  • 83.76 (n)
OneToOne
Or2t26 46 Olfr1395
  • chr11:49,148,259-49,149,209
Or2z2 46 Olfr30
  • chr11:58,455,003-58,455,947
Species where no ortholog for OR2T1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2T1 Gene

ENSEMBL:
Gene Tree for OR2T1 (if available)
TreeFam:
Gene Tree for OR2T1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2T1: view image

Paralogs for OR2T1 Gene

(447) SIMAP similar genes for OR2T1 Gene using alignment to 1 proteins:

  • OR2T1_HUMAN
genes like me logo Genes that share paralogs with OR2T1: view

Variants for OR2T1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2T1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs193920936 Uncertain Significance: Malignant tumor of prostate 248,406,130(+) G/A MISSENSE_VARIANT
rs28599722 - p.His25Arg

Additional dbSNP identifiers (rs#s) for OR2T1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2T1 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv613n100 CNV loss 25217958
dgv906n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv428357 CNV loss 18775914
nsv511035 OTHER complex 20534489
nsv515858 CNV gain+loss 19592680
nsv5332 CNV deletion 18451855
nsv5343 CNV insertion 18451855
nsv549603 CNV loss 21841781
nsv549630 CNV loss 21841781

Variation tolerance for OR2T1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T1 Gene

Disorders for OR2T1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR2T1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search OR2T1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OR2T1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2T1 Gene

Publications for OR2T1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. (PMID: 27684187) Rosenbluh J … Hahn WC (Cell systems 2016) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2T1 Gene

Sources for OR2T1 Gene