Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2S2 Gene

Aliases for OR2S2 Gene

  • Olfactory Receptor Family 2 Subfamily S Member 2 2 3 5
  • Olfactory Receptor OR9-3 3 4
  • Olfactory Receptor 2S2 3 4
  • Olfactory Receptor, Family 2, Subfamily S, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 2 Subfamily S Member 2 (Gene/Pseudogene) 2
  • OST715 3
  • OR37A 3
  • OR2S2 5

External Ids for OR2S2 Gene

Previous GeneCards Identifiers for OR2S2 Gene

  • GC09M036269
  • GC09M036126

Summaries for OR2S2 Gene

Entrez Gene Summary for OR2S2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR2S2 Gene

OR2S2 (Olfactory Receptor Family 2 Subfamily S Member 2) is a Protein Coding gene. Diseases associated with OR2S2 include Spindle Cell Hemangioma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C8.

UniProtKB/Swiss-Prot Summary for OR2S2 Gene

Gene Wiki entry for OR2S2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2S2 Gene

Genomics for OR2S2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2S2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J036028 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 8 -71.5 -71500 2.3 JUND CEBPB EP300 RFX5 STAT3 ZBTB21 BHLHE40 POLR2A FOS ATF3 OR2S2 RECK OR13J1 HSALNG0070976
GH09J036150 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.2 -194.8 -194830 6 BCLAF1 SP1 POLR2A BCL11A CTCF BHLHE40 GABPA IRF4 ETV4 RARA GLIPR2 GNE HMGB3P24 OR2S2 TLN1 OR13J1 HSALNG0070981 HSALNG0070980 CCIN
GH09J036035 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.4 -80.1 -80121 4.7 ZNF600 POLR2A ZBTB10 CHD2 FEZF1 KMT2B KLF9 SP2 SAP130 YY1 RECK GLIPR2 ATP8B5P OR2S2 HSALNG0070977
GH09J035904 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.7 +49.3 49308 8.7 ZNF654 JUND ZMYM3 ZNF10 POLR2A NFIC ZIC2 YY1 CEBPB REST SPAAR NONHSAG052133.2 HRCT1 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 NPR2 ENSG00000227388
GH09J036294 Enhancer 0.2 FANTOM5 10.1 -336.0 -336014 0.2 OR2S2 GNE OR13J1 HSALNG0070990 lnc-CLTA-2 LOC102724322 MN298114-284 CLTA RNF38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2S2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2S2

Top Transcription factor binding sites by QIAGEN in the OR2S2 gene promoter:
  • Egr-2
  • FOXD3
  • MyoD
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1
  • POU2F1a
  • ZID

Genomic Locations for OR2S2 Gene

Latest Assembly
chr9:35,957,108-35,958,154
(GRCh38/hg38)
Size:
1,047 bases
Orientation:
Minus strand

Previous Assembly
chr9:35,957,105-35,958,151
(GRCh37/hg19 by Entrez Gene)
Size:
1,047 bases
Orientation:
Minus strand

Genomic View for OR2S2 Gene

Genes around OR2S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2S2 Gene

Proteins for OR2S2 Gene

  • Protein details for OR2S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQN1-OR2S1_HUMAN
    Recommended name:
    Olfactory receptor 2S2
    Protein Accession:
    Q9NQN1
    Secondary Accessions:
    • Q2M3L0
    • Q6IF19
    • Q96R42

    Protein attributes for OR2S2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2S2 Gene

Post-translational modifications for OR2S2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2S2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2S2 Gene

Domains & Families for OR2S2 Gene

Gene Families for OR2S2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2S2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2S2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-3 (OR2S1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQN1

UniProtKB/Swiss-Prot:

OR2S1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2S2: view

Function for OR2S2 Gene

Molecular function for OR2S2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2S2 Gene

Gene Ontology (GO) - Molecular Function for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view
genes like me logo Genes that share phenotypes with OR2S2: view

Animal Models for research

miRNA for OR2S2 Gene

miRTarBase miRNAs that target OR2S2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2S2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2S2 Gene

Localization for OR2S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2S2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2S2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2S2 Gene

Pathways & Interactions for OR2S2 Gene

genes like me logo Genes that share pathways with OR2S2: view

Pathways by source for OR2S2 Gene

1 KEGG pathway for OR2S2 Gene

Interacting Proteins for OR2S2 Gene

Gene Ontology (GO) - Biological Process for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 14983052
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2S2: view

No data available for SIGNOR curated interactions for OR2S2 Gene

Drugs & Compounds for OR2S2 Gene

No Compound Related Data Available

Transcripts for OR2S2 Gene

mRNA/cDNA for OR2S2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2S2

Alternative Splicing Database (ASD) splice patterns (SP) for OR2S2 Gene

No ASD Table

Relevant External Links for OR2S2 Gene

GeneLoc Exon Structure for
OR2S2

Expression for OR2S2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2S2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2S2

SOURCE GeneReport for Unigene cluster for OR2S2 Gene:

Hs.553540

Evidence on tissue expression from TISSUES for OR2S2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR2S2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2S2 Gene

Orthologs for OR2S2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2S2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR2S2 29
  • 98.43 (n)
Cow
(Bos Taurus)
Mammalia OR2S2 29
  • 87.98 (n)
Dog
(Canis familiaris)
Mammalia LOC609676 29
  • 86 (n)
Rat
(Rattus norvegicus)
Mammalia Olr840 29
  • 84.54 (n)
Mouse
(Mus musculus)
Mammalia Olfr155 29 16
  • 84.12 (n)
Species where no ortholog for OR2S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2S2 Gene

ENSEMBL:
Gene Tree for OR2S2 (if available)
TreeFam:
Gene Tree for OR2S2 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR2S2

Paralogs for OR2S2 Gene

(451) SIMAP similar genes for OR2S2 Gene using alignment to 1 proteins:

  • OR2S1_HUMAN

Pseudogenes.org Pseudogenes for OR2S2 Gene

genes like me logo Genes that share paralogs with OR2S2: view

Variants for OR2S2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2S2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs2233559 Benign: not provided 35,958,011(-) C/Tp.Val30Met
NM_019897.2(OR2S2):c.88G>A (p.Val30Met)
MISSENSE
rs2233558 -- p.Arg17Gly
rs2233560 -- p.Pro89Ser
rs2233563 -- p.Arg123His
rs2233564 -- p.Met143Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2S2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2S2 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897
nsv968611 CNV duplication 23825009

Variation tolerance for OR2S2 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.98; 92.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2S2
Leiden Open Variation Database (LOVD)
OR2S2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2S2 Gene

Disorders for OR2S2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR2S2 Gene - From: COP

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards
Search OR2S2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR2S2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR2S2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2S2 Gene

Publications for OR2S2 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

Products for OR2S2 Gene

Sources for OR2S2 Gene