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Aliases for OR2M4 Gene

Aliases for OR2M4 Gene

  • Olfactory Receptor Family 2 Subfamily M Member 4 2 3 5
  • Olfactory Receptor TPCR100 3 4
  • Olfactory Receptor OR1-55 3 4
  • HTPCRX18 3 4
  • OST710 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor, Family 2, Subfamily M, Member 4 2
  • Olfactory Receptor 2M4 3
  • HSHTPCRX18 3
  • TPCR100 3
  • OR1-55 3

External Ids for OR2M4 Gene

Previous GeneCards Identifiers for OR2M4 Gene

  • GC01P246270
  • GC01M243650
  • GC01P244450
  • GC01P245299
  • GC01P244730
  • GC01P246468
  • GC01P248402

Summaries for OR2M4 Gene

Entrez Gene Summary for OR2M4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M4 Gene

OR2M4 (Olfactory Receptor Family 2 Subfamily M Member 4) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2M7.

UniProtKB/Swiss-Prot for OR2M4 Gene

  • Odorant receptor.

Gene Wiki entry for OR2M4 Gene

Additional gene information for OR2M4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M4 Gene

Genomics for OR2M4 Gene

GeneHancer (GH) Regulatory Elements for OR2M4 Gene

Promoters and enhancers for OR2M4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248471 Enhancer 0.5 FANTOM5 12.2 +240.3 240335 0.4 HDGF TARDBP ZNF207 MAFG OR2T3 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2M4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2M4 gene promoter:
  • FOXC1
  • FAC1
  • MyoD
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for OR2M4 Gene

Genomic Locations for OR2M4 Gene
13,263 bases
Plus strand
936 bases
Plus strand

Genomic View for OR2M4 Gene

Genes around OR2M4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2M4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2M4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M4 Gene

Proteins for OR2M4 Gene

  • Protein details for OR2M4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2M4
    Protein Accession:
    Secondary Accessions:
    • Q15611
    • Q8NG82

    Protein attributes for OR2M4 Gene

    311 amino acids
    Molecular mass:
    35071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M4 Gene

Post-translational modifications for OR2M4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2M4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2M4 Gene

Domains & Families for OR2M4 Gene

Gene Families for OR2M4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2M4 Gene

Suggested Antigen Peptide Sequences for OR2M4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2M4: view

Function for OR2M4 Gene

Molecular function for OR2M4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2M4 Gene

Gene Ontology (GO) - Molecular Function for OR2M4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR2M4: view
genes like me logo Genes that share phenotypes with OR2M4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2M4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2M4 Gene

Localization for OR2M4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2M4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IBA 9119360
genes like me logo Genes that share ontologies with OR2M4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2M4 Gene

Pathways & Interactions for OR2M4 Gene

genes like me logo Genes that share pathways with OR2M4: view

Pathways by source for OR2M4 Gene

1 BioSystems pathway for OR2M4 Gene
1 KEGG pathway for OR2M4 Gene

Gene Ontology (GO) - Biological Process for OR2M4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS,IBA 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2M4: view

No data available for SIGNOR curated interactions for OR2M4 Gene

Drugs & Compounds for OR2M4 Gene

No Compound Related Data Available

Transcripts for OR2M4 Gene

mRNA/cDNA for OR2M4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2M4 Gene

Olfactory receptor, family 2, subfamily M, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2M4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M4 Gene

No ASD Table

Relevant External Links for OR2M4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2M4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2M4 Gene

mRNA differential expression in normal tissues according to GTEx for OR2M4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Frontal Cortex (BA9) (x7.3), Brain - Hypothalamus (x6.4), Brain - Cortex (x6.0), Brain - Spinal cord (cervical c-1) (x5.5), and Brain - Substantia nigra (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of OR2M4 Gene:


SOURCE GeneReport for Unigene cluster for OR2M4 Gene:

genes like me logo Genes that share expression patterns with OR2M4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2M4 Gene

Orthologs for OR2M4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469765 33
  • 98.93 (n)
OR2M4 34
  • 98 (a)
(Bos Taurus)
Mammalia OR2M4 34 33
  • 82.47 (n)
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
(Mus musculus)
Mammalia Olfr315 34
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
Species where no ortholog for OR2M4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M4 Gene

Gene Tree for OR2M4 (if available)
Gene Tree for OR2M4 (if available)
Evolutionary constrained regions (ECRs) for OR2M4: view image

Paralogs for OR2M4 Gene

(447) SIMAP similar genes for OR2M4 Gene using alignment to 1 proteins:

  • OR2M4_HUMAN Pseudogenes for OR2M4 Gene

genes like me logo Genes that share paralogs with OR2M4: view

Variants for OR2M4 Gene

Sequence variations from dbSNP and Humsavar for OR2M4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000967718 -- 248,240,196(+) T/A downstream_transcript_variant
rs1001006193 -- 248,239,706(+) A/G coding_sequence_variant, missense_variant
rs1001037226 -- 248,239,991(+) A/T downstream_transcript_variant
rs1002202258 -- 248,240,364(+) A/G downstream_transcript_variant
rs1003411915 -- 248,238,214(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2M4 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv611n100 CNV gain 25217958
dgv612n100 CNV loss 25217958
dgv613n100 CNV loss 25217958
dgv614n100 CNV loss 25217958
dgv85e214 CNV loss 21293372
dgv904n54 CNV gain 21841781
dgv905n54 CNV gain 21841781
esv2728006 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv3589544 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1006563 CNV gain+loss 25217958
nsv1013273 CNV gain 25217958
nsv468861 CNV gain 19166990
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549626 CNV loss 21841781
nsv549629 CNV gain 21841781
nsv549630 CNV loss 21841781
nsv9103 CNV loss 18304495

Variation tolerance for OR2M4 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2M4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2M4 Gene

Disorders for OR2M4 Gene

Additional Disease Information for OR2M4

No disorders were found for OR2M4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2M4 Gene

Publications for OR2M4 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4 58
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58

Products for OR2M4 Gene

Sources for OR2M4 Gene

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