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Aliases for OR2L2 Gene

Aliases for OR2L2 Gene

  • Olfactory Receptor Family 2 Subfamily L Member 2 2 3 5
  • Olfactory Receptor 2L12 3 4
  • Olfactory Receptor 2L4 3 4
  • HTPCRH07 3 4
  • OR2L12 3 4
  • OR2L4P 3 4
  • Olfactory Receptor, Family 2, Subfamily L, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily L, Member 12 3
  • Olfactory Receptor, Family 2, Subfamily L, Member 2 2
  • Olfactory Receptor OR1-48 Pseudogene 3
  • Olfactory Receptor 2L2 3
  • HSHTPCRH07 3
  • OR1-48 3

External Ids for OR2L2 Gene

Previous HGNC Symbols for OR2L2 Gene

  • OR2L4P
  • OR2L12

Previous GeneCards Identifiers for OR2L2 Gene

  • GC01U990263
  • GC01P245100
  • GC01P244527
  • GC01P246268
  • GC01P248201

Summaries for OR2L2 Gene

Entrez Gene Summary for OR2L2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2L2 Gene

OR2L2 (Olfactory Receptor Family 2 Subfamily L Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L5.

UniProtKB/Swiss-Prot for OR2L2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2L2 Gene

Additional gene information for OR2L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2L2 Gene

Genomics for OR2L2 Gene

GeneHancer (GH) Regulatory Elements for OR2L2 Gene

Top Transcription factor binding sites by QIAGEN in the OR2L2 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • c-Fos
  • FAC1

Genomic Locations for OR2L2 Gene

Genomic Locations for OR2L2 Gene
12,236 bases
Plus strand
1,134 bases
Plus strand

Genomic View for OR2L2 Gene

Genes around OR2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2L2 Gene

Proteins for OR2L2 Gene

  • Protein details for OR2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2L2
    Protein Accession:
    Secondary Accessions:
    • Q2M3T5

    Protein attributes for OR2L2 Gene

    312 amino acids
    Molecular mass:
    35495 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2L2 Gene

Post-translational modifications for OR2L2 Gene

  • Glycosylation at isoforms=88 and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2L2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2L2 Gene

Domains & Families for OR2L2 Gene

Gene Families for OR2L2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2L2 Gene

Suggested Antigen Peptide Sequences for OR2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2L2: view

Function for OR2L2 Gene

Molecular function for OR2L2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2L2: view

Phenotypes for OR2L2 Gene

genes like me logo Genes that share phenotypes with OR2L2: view

Animal Model Products

miRNA for OR2L2 Gene

miRTarBase miRNAs that target OR2L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2L2 Gene

Localization for OR2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2L2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2L2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2L2 Gene

Pathways & Interactions for OR2L2 Gene

genes like me logo Genes that share pathways with OR2L2: view

Pathways by source for OR2L2 Gene

Gene Ontology (GO) - Biological Process for OR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR2L2: view

No data available for SIGNOR curated interactions for OR2L2 Gene

Drugs & Compounds for OR2L2 Gene

No Compound Related Data Available

Transcripts for OR2L2 Gene

mRNA/cDNA for OR2L2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2L2 Gene

Olfactory receptor, family 2, subfamily L, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2L2 Gene

No ASD Table

Relevant External Links for OR2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2L2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2L2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.9), Testis (x6.7), Brain - Substantia nigra (x5.0), Brain - Putamen (basal ganglia) (x4.8), and Brain - Hippocampus (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of OR2L2 Gene:


SOURCE GeneReport for Unigene cluster for OR2L2 Gene:


Evidence on tissue expression from TISSUES for OR2L2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR2L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2L2 Gene

Orthologs for OR2L2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469758 33
  • 98.72 (n)
(Bos Taurus)
Mammalia -- 34
  • 83 (a)
OR2L2 33
  • 82.69 (n)
-- 34
  • 81 (a)
-- 34
  • 80 (a)
-- 34
  • 80 (a)
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
-- 34
  • 80 (a)
-- 34
  • 80 (a)
-- 34
  • 79 (a)
-- 34
  • 78 (a)
(Rattus norvegicus)
Mammalia LOC100911043 33
  • 79.91 (n)
(Mus musculus)
Mammalia Olfr167 16 34 33
  • 79.8 (n)
Or2av9 51 Olfr332
  • chr11:58,489,722-58,490,753
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
Species where no ortholog for OR2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2L2 Gene

Gene Tree for OR2L2 (if available)
Gene Tree for OR2L2 (if available)
Evolutionary constrained regions (ECRs) for OR2L2: view image

Paralogs for OR2L2 Gene

Paralogs for OR2L2 Gene

(450) SIMAP similar genes for OR2L2 Gene using alignment to 1 proteins:

  • OR2L2_HUMAN Pseudogenes for OR2L2 Gene

genes like me logo Genes that share paralogs with OR2L2: view

Variants for OR2L2 Gene

Sequence variations from dbSNP and Humsavar for OR2L2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000606271 -- 248,037,160(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001048871 -- 248,037,881(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001143309 -- 248,038,135(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001785697 -- 248,034,208(+) C/G upstream_transcript_variant
rs1002653470 -- 248,039,540(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2L2 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv609n100 CNV loss 25217958
dgv63e201 CNV deletion 23290073
dgv903n54 CNV loss 21841781
esv2663706 CNV deletion 23128226
esv2727929 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3575883 CNV gain 25503493
esv3578541 CNV loss 25503493
esv3589529 CNV loss 21293372
esv3891415 CNV gain 25118596
nsv1004090 CNV loss 25217958
nsv1008024 CNV gain 25217958
nsv1013071 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549621 CNV loss 21841781
nsv945451 CNV duplication 23825009

Variation tolerance for OR2L2 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2L2 Gene

Disorders for OR2L2 Gene

Additional Disease Information for OR2L2

No disorders were found for OR2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2L2 Gene

Publications for OR2L2 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2L2 Gene

Sources for OR2L2 Gene

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