Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2L13 Gene

Aliases for OR2L13 Gene

  • Olfactory Receptor Family 2 Subfamily L Member 13 2 3 5
  • Olfactory Receptor 2L13 3 4
  • Olfactory Receptor 2L14 3 4
  • OR2L14 3 4
  • Olfactory Receptor, Family 2, Subfamily L, Member 13 2
  • Olfactory Receptor, Family 2, Subfamily L, Member 14 3
  • OR2L13 5

External Ids for OR2L13 Gene

Previous HGNC Symbols for OR2L13 Gene

  • OR2L14

Previous GeneCards Identifiers for OR2L13 Gene

  • GC00U915464
  • GC01P244426
  • GC01P246167
  • GC01P248100

Summaries for OR2L13 Gene

Entrez Gene Summary for OR2L13 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2L13 Gene

OR2L13 (Olfactory Receptor Family 2 Subfamily L Member 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L8.

UniProtKB/Swiss-Prot Summary for OR2L13 Gene

Gene Wiki entry for OR2L13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2L13 Gene

Genomics for OR2L13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2L13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247936 Promoter/Enhancer 1.2 Ensembl ENCODE 267.6 +0.1 103 1.4 BCLAF1 ZNF654 ZNF600 MYC CTCF REST TRIM22 TBP MNT HCFC1 OR2L13 CLK3P2 OR2X1P lnc-OR11L1-2 lnc-OR2AJ1-1 OR2L8
GH01J247858 Enhancer 0.7 ENCODE 10.6 -78.1 -78076 0.5 NCOR1 MNT ARNT TAL1 ZNF316 NFE2 HDAC2 FOXK2 MAFG MAFK TRIM58 OR2AJ1 OR2T8 OR2L13 OR2X1P CLK3P2 RF00017-496 OR2W3
GH01J247860 Enhancer 0.2 Ensembl 10.4 -77.1 -77076 0.2 OR2T8 OR2L13 OR2X1P CLK3P2 OR2AJ1 TRIM58 RF00017-496 OR2W3
GH01J247962 Enhancer 0.2 Ensembl 0.3 +26.1 26124 0.2 OR2AK2 OR2L2 OR2L8 OR2L13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2L13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2L13

Top Transcription factor binding sites by QIAGEN in the OR2L13 gene promoter:
  • AML1a
  • Bach2
  • Pax-3
  • Pax-4a
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • USF-1
  • USF1

Genomic Locations for OR2L13 Gene

Latest Assembly
163,987 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
163,746 bases
Plus strand

(GRCh37/hg19 by Ensembl)
163,732 bases
Plus strand

Genomic View for OR2L13 Gene

Genes around OR2L13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2L13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2L13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2L13 Gene

Proteins for OR2L13 Gene

  • Protein details for OR2L13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2L13
    Protein Accession:
    Secondary Accessions:
    • Q5VUR5

    Protein attributes for OR2L13 Gene

    312 amino acids
    Molecular mass:
    35634 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2L13 Gene

Post-translational modifications for OR2L13 Gene

  • Glycosylation at Asn5 and Asn20
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2L13 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2L13 Gene

Domains & Families for OR2L13 Gene

Gene Families for OR2L13 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2L13 Gene

  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2L13 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 2L14 (OR2LD_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2L13: view

Function for OR2L13 Gene

Molecular function for OR2L13 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2L13 Gene

Gene Ontology (GO) - Molecular Function for OR2L13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0005515 protein binding IPI 19945174
genes like me logo Genes that share ontologies with OR2L13: view
genes like me logo Genes that share phenotypes with OR2L13: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2L13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2L13 Gene

Localization for OR2L13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2L13 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2L13 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OR2L13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2L13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2L13 Gene

Pathways & Interactions for OR2L13 Gene

genes like me logo Genes that share pathways with OR2L13: view

Pathways by source for OR2L13 Gene

Interacting Proteins for OR2L13 Gene

Gene Ontology (GO) - Biological Process for OR2L13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR2L13: view

No data available for SIGNOR curated interactions for OR2L13 Gene

Drugs & Compounds for OR2L13 Gene

No Compound Related Data Available

Transcripts for OR2L13 Gene

mRNA/cDNA for OR2L13 Gene

1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2L13

Alternative Splicing Database (ASD) splice patterns (SP) for OR2L13 Gene

No ASD Table

Relevant External Links for OR2L13 Gene

GeneLoc Exon Structure for

Expression for OR2L13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2L13 Gene

mRNA differential expression in normal tissues according to GTEx for OR2L13 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.7), Brain - Frontal Cortex (BA9) (x6.2), Brain - Substantia nigra (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Hypothalamus (x4.5), and Brain - Hippocampus (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2L13

SOURCE GeneReport for Unigene cluster for OR2L13 Gene:


Evidence on tissue expression from TISSUES for OR2L13 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with OR2L13: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2L13 Gene

Orthologs for OR2L13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2L13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469762 29
  • 99.47 (n)
OR2L13 30
  • 99 (a)
(Canis familiaris)
Mammalia OR2L13 30
  • 86 (a)
(Bos Taurus)
Mammalia OR2L13 29 30
  • 85.96 (n)
(Mus musculus)
Mammalia Or2l13b 45 Olfr168 30
  • 84 (a)
Or2l13 45 Olfr166 29 16 30
  • 80.13 (n)
(Rattus norvegicus)
Mammalia Olr1569 29
  • 78.56 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 69 (a)
Species where no ortholog for OR2L13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2L13 Gene

Gene Tree for OR2L13 (if available)
Gene Tree for OR2L13 (if available)
Evolutionary constrained regions (ECRs) for OR2L13: view image
Alliance of Genome Resources:
Additional Orthologs for OR2L13

Paralogs for OR2L13 Gene

(432) SIMAP similar genes for OR2L13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2L13: view

Variants for OR2L13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2L13 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs74153215 Benign: not provided 247,965,423(+) G/A
NM_001004491.1(OR2AK2):c.92G>A (p.Gly31Asp)
rs74153216 Benign: not provided 247,965,679(+) G/A
NM_001004491.1(OR2AK2):c.348G>A (p.Thr116=)
rs74153217 Benign: not provided 247,965,871(+) G/A
NM_001004491.1(OR2AK2):c.540G>A (p.Gln180=)
rs74153219 Benign: not provided 247,966,000(+) A/G
NM_001004491.1(OR2AK2):c.669A>G (p.Leu223=)
rs74153221 Benign: not provided 247,966,199(+) G/A
NM_001004491.1(OR2AK2):c.868G>A (p.Ala290Thr)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2L13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2L13 Gene

Variant ID Type Subtype PubMed ID
dgv111e199 CNV deletion 23128226
dgv17e55 CNV loss 17911159
dgv322n106 CNV deletion 24896259
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv609n100 CNV loss 25217958
dgv610n100 CNV loss 25217958
dgv611n100 CNV gain 25217958
dgv612n100 CNV loss 25217958
dgv63e201 CNV deletion 23290073
dgv64e201 CNV deletion 23290073
dgv901n54 CNV loss 21841781
dgv902n54 CNV loss 21841781
dgv903n54 CNV loss 21841781
dgv904n54 CNV gain 21841781
esv2035728 CNV deletion 18987734
esv2613716 CNV deletion 19546169
esv2663706 CNV deletion 23128226
esv2727929 CNV deletion 23290073
esv2727984 CNV deletion 23290073
esv2727995 CNV deletion 23290073
esv2728006 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv29107 CNV gain 19812545
esv29477 CNV loss 19812545
esv33129 CNV gain+loss 17666407
esv3381430 CNV insertion 20981092
esv34503 CNV gain 17911159
esv3550543 CNV deletion 23714750
esv3550554 CNV deletion 23714750
esv3575883 CNV gain 25503493
esv3578540 CNV loss 25503493
esv3578541 CNV loss 25503493
esv3578542 CNV loss 25503493
esv3589522 CNV gain 21293372
esv3589529 CNV loss 21293372
esv3589530 CNV loss 21293372
esv3589531 CNV loss 21293372
esv3589532 CNV gain 21293372
esv3589533 CNV loss 21293372
esv3589535 CNV loss 21293372
esv3589536 CNV gain 21293372
esv3589537 CNV loss 21293372
esv3589538 CNV gain 21293372
esv3861 CNV loss 18987735
esv3891415 CNV gain 25118596
nsv1004090 CNV loss 25217958
nsv1006563 CNV gain+loss 25217958
nsv1008024 CNV gain 25217958
nsv1013071 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv468861 CNV gain 19166990
nsv508070 OTHER sequence alteration 20534489
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549605 CNV loss 21841781
nsv549613 CNV loss 21841781
nsv549618 CNV loss 21841781
nsv549621 CNV loss 21841781
nsv827786 CNV loss 20364138
nsv827797 CNV loss 20364138
nsv9080 CNV gain 18304495
nsv9091 CNV loss 18304495
nsv945443 CNV duplication 23825009
nsv945444 CNV duplication 23825009
nsv945449 CNV duplication 23825009
nsv945450 CNV duplication 23825009
nsv945451 CNV duplication 23825009
nsv945452 CNV duplication 23825009
nsv945453 CNV duplication 23825009
nsv945454 CNV duplication 23825009
nsv955435 CNV deletion 24416366

Variation tolerance for OR2L13 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2L13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2L13 Gene

Disorders for OR2L13 Gene

Additional Disease Information for OR2L13

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR2L13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2L13 Gene

Publications for OR2L13 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Maternal 5mCpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues. (PMID: 29545821) de Sá Machado Araújo G … Medina-Acosta E (Frontiers in genetics 2018) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2L13 Gene

Sources for OR2L13 Gene