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Aliases for OR2K2 Gene

Aliases for OR2K2 Gene

  • Olfactory Receptor Family 2 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR9-17 3 4
  • HTPCRH06 3 4
  • OR2AR1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AN, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily AR, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily K, Member 2 2
  • Olfactory Receptor 2K2 3
  • HSHTPCRH06 3
  • OR2AN1P 3

External Ids for OR2K2 Gene

Previous HGNC Symbols for OR2K2 Gene

  • OR2AR1P

Previous GeneCards Identifiers for OR2K2 Gene

  • GC09M104887
  • GC09M105821
  • GC09M107547
  • GC09M109469
  • GC09M111169
  • GC09M113129
  • GC09M114089

Summaries for OR2K2 Gene

Entrez Gene Summary for OR2K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2K2 Gene

OR2K2 (Olfactory Receptor Family 2 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13F1.

UniProtKB/Swiss-Prot for OR2K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2K2 Gene

Additional gene information for OR2K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2K2 Gene

Genomics for OR2K2 Gene

GeneHancer (GH) Regulatory Elements for OR2K2 Gene

Promoters and enhancers for OR2K2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J111288 Enhancer 0.6 ENCODE 10.3 +41.2 41227 0.2 JUNB EBF1 MEF2B DPF2 BATF ZNF217 IKZF1 EED NBN IKZF2 OR2K2 PTGR1 LOC105376219
GH09J111350 Enhancer 0.4 FANTOM5 9.4 -19.2 -19176 0 ZNF384 YY1 OR2K2 PIR34688 RNA5SP294
GH09J111286 Enhancer 0.2 ENCODE 10.3 +42.8 42812 1 LPAR1 OR2K2 ENSG00000227531 LOC105376219
GH09J111235 Enhancer 0.2 ENCODE 9.6 +93.8 93832 1.7 OR2K2 LPAR1 ZNF483 MIR7702 LOC105376219 ENSG00000227531 RNY4P18 GC09M111098
GH09J110883 Enhancer 0.2 FANTOM5 8.2 +446.6 446589 0.1 LPAR1 OR2K2 GC09P110904 GC09P110867
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2K2 gene promoter:
  • AML1a
  • MEF-2A
  • aMEF-2
  • Tal-1beta
  • ITF-2
  • Cdc5
  • c-Rel
  • RSRFC4
  • XBP-1

Genomic Locations for OR2K2 Gene

Genomic Locations for OR2K2 Gene
2,814 bases
Minus strand
1,038 bases
Minus strand

Genomic View for OR2K2 Gene

Genes around OR2K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2K2 Gene

Proteins for OR2K2 Gene

  • Protein details for OR2K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2K2
    Protein Accession:
    Secondary Accessions:
    • Q2TA61
    • Q5VYK4
    • Q6IFI5

    Protein attributes for OR2K2 Gene

    345 amino acids
    Molecular mass:
    38473 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05929.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH73239.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR2K2 Gene

Post-translational modifications for OR2K2 Gene

  • Glycosylation at Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2K2 Gene

Domains & Families for OR2K2 Gene

Gene Families for OR2K2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2K2 Gene

Suggested Antigen Peptide Sequences for OR2K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2K2: view

Function for OR2K2 Gene

Molecular function for OR2K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2K2 Gene

Gene Ontology (GO) - Molecular Function for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2K2: view
genes like me logo Genes that share phenotypes with OR2K2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2K2 Gene

Localization for OR2K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2K2 Gene

Pathways & Interactions for OR2K2 Gene

genes like me logo Genes that share pathways with OR2K2: view

Pathways by source for OR2K2 Gene

Interacting Proteins for OR2K2 Gene

Gene Ontology (GO) - Biological Process for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2K2: view

No data available for SIGNOR curated interactions for OR2K2 Gene

Drugs & Compounds for OR2K2 Gene

No Compound Related Data Available

Transcripts for OR2K2 Gene

mRNA/cDNA for OR2K2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2K2 Gene

Olfactory receptor, family 2, subfamily K, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2K2 Gene

No ASD Table

Relevant External Links for OR2K2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2K2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2K2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.0), Muscle - Skeletal (x6.6), and Brain - Substantia nigra (x6.4).

NURSA nuclear receptor signaling pathways regulating expression of OR2K2 Gene:


SOURCE GeneReport for Unigene cluster for OR2K2 Gene:

genes like me logo Genes that share expression patterns with OR2K2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2K2 Gene

Orthologs for OR2K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2K2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473017 33
  • 99.05 (n)
OR2K2 34
  • 90 (a)
(Canis familiaris)
Mammalia LOC100856036 33
  • 87.66 (n)
OR2K2 34
  • 85 (a)
(Bos Taurus)
Mammalia LOC539574 33
  • 87.55 (n)
OR2K2 34
  • 86 (a)
(Mus musculus)
Mammalia Or2k2 51 Olfr267 16 34 33
  • 85.15 (n)
(Rattus norvegicus)
Mammalia Olr854 33
  • 84.47 (n)
(Monodelphis domestica)
Mammalia OR2K2 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
Species where no ortholog for OR2K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2K2 Gene

Gene Tree for OR2K2 (if available)
Gene Tree for OR2K2 (if available)
Evolutionary constrained regions (ECRs) for OR2K2: view image

Paralogs for OR2K2 Gene

(458) SIMAP similar genes for OR2K2 Gene using alignment to 1 proteins:

  • OR2K2_HUMAN Pseudogenes for OR2K2 Gene

genes like me logo Genes that share paralogs with OR2K2: view

Variants for OR2K2 Gene

Sequence variations from dbSNP and Humsavar for OR2K2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000271655 -- 111,330,290(-) G/A upstream_transcript_variant
rs1000721788 -- 111,330,493(-) C/T upstream_transcript_variant
rs1001016940 -- 111,329,372(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002734727 -- 111,327,855(-) G/A coding_sequence_variant, synonymous_variant
rs1002860810 -- 111,329,056(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for OR2K2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR2K2 Gene

Disorders for OR2K2 Gene

Additional Disease Information for OR2K2

No disorders were found for OR2K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2K2 Gene

Publications for OR2K2 Gene

  1. Ancient genomic architecture for mammalian olfactory receptor clusters. (PMID: 17010214) Aloni R … Lancet D (Genome biology 2006) 2 3 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 58

Products for OR2K2 Gene

Sources for OR2K2 Gene

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