Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]
OR2J3 (Olfactory Receptor Family 2 Subfamily J Member 3) is a Protein Coding gene. Diseases associated with OR2J3 include C3hex, Ability To Smell. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J028814 | Enhancer | 0.8 | FANTOM5 | 2.9 | -293.7 | -293681 | 0.1 | PRDM10 ZNF629 IKZF1 ZNF692 PRDM1 ZSCAN4 POLR2A PATZ1 ZNF501 EZH2 | ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3 OR2B3 | |
GH06J029467 | Enhancer | 0.2 | FANTOM5 | 6.4 | +359.6 | 359640 | 0.3 | OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1 | ||
GH06J028854 | Enhancer | 0.5 | FANTOM5 | 2.2 | -253.2 | -253175 | 0.2 | HDAC2 FOXA2 ZMYM3 KDM1A | HCG14 TRIM27 HCG15 ENSG00000244349 ZNF602P OR2J3 OR2B3 OR14J1 RPL13P piR-55194-322 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471931 30 |
|
||
OR2J3 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
OR2J3 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Olfr1381 31 |
|
ManyToMany | |
Or2j3 46 Olfr137 |
|
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs28757581 | Affects: C3HEX, ability to smell. - | 29,112,227(+) | A/Gp.Thr113Ala | MISSENSE_VARIANT | |
rs3749977 | Affects: C3HEX, ability to smell. - | 29,112,567(+) | G/Ap.Arg226Gln | MISSENSE_VARIANT | |
rs3130764 | - | p.Val228Ile | |||
rs3130765 | - | p.Ile261Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10338n54 | CNV | gain | 21841781 |
dgv1172e214 | CNV | gain | 21293372 |
dgv1173e214 | CNV | loss | 21293372 |
esv2763545 | CNV | loss | 21179565 |
nsv1015796 | CNV | gain | 25217958 |
nsv1032468 | CNV | loss | 25217958 |
nsv1074388 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1145096 | CNV | deletion | 24896259 |
nsv428138 | CNV | gain+loss | 18775914 |
nsv601216 | CNV | gain | 21841781 |
nsv830623 | CNV | gain | 17160897 |
nsv970098 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
c3hex, ability to smell |
|
|