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Aliases for OR2J3 Gene

Aliases for OR2J3 Gene

  • Olfactory Receptor Family 2 Subfamily J Member 3 2 3 5
  • Olfactory Receptor OR6-16 3 4
  • Olfactory Receptor 6-6 3 4
  • OR6-6 3 4
  • Olfactory Receptor, Family 2, Subfamily J, Member 3 2
  • Olfactory Receptor 2J3 3
  • HS6M1-3 3
  • OR6.3.6 3
  • Hs6M1-3 4
  • C3HEXS 3
  • OR6-16 3
  • ORL671 3
  • 6M1-3 3

External Ids for OR2J3 Gene

Previous GeneCards Identifiers for OR2J3 Gene

  • GC06U990203
  • GC06P029188
  • GC06P029079
  • GC06P028887

Summaries for OR2J3 Gene

Entrez Gene Summary for OR2J3 Gene

  • This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]

GeneCards Summary for OR2J3 Gene

OR2J3 (Olfactory Receptor Family 2 Subfamily J Member 3) is a Protein Coding gene. Diseases associated with OR2J3 include C3hex, Ability To Smell. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.

UniProtKB/Swiss-Prot for OR2J3 Gene

  • Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as green grassy or the smell of cut grass.

Gene Wiki entry for OR2J3 Gene

Additional gene information for OR2J3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2J3 Gene

Genomics for OR2J3 Gene

GeneHancer (GH) Regulatory Elements for OR2J3 Gene

Promoters and enhancers for OR2J3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J028814 Enhancer 0.9 FANTOM5 2.9 -293.7 -293681 0.1 ZSCAN4 KLF17 ZBTB40 ZNF2 ETS1 ZNF335 ZNF213 ZNF366 KLF7 EGR2 ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3 OR2B3
GH06J029467 Enhancer 0.2 FANTOM5 6.4 +359.6 359640 0.3 GC06M029436 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2
GH06J028854 Enhancer 0.5 FANTOM5 2.2 -253.2 -253175 0.2 FOXA2 HDAC2 ZMYM3 KDM1A HCG14 TRIM27 ENSG00000244349 HCG15 ZNF602P OR2J3 OR2B3 OR14J1 RPL13P ENSG00000225173
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2J3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2J3 gene promoter:
  • deltaCREB
  • CREB
  • GR
  • GR-alpha
  • GR-beta
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Nkx3-1
  • Nkx3-1 v1

Genomic Locations for OR2J3 Gene

Genomic Locations for OR2J3 Gene
6,712 bases
Plus strand
936 bases
Plus strand

Genomic View for OR2J3 Gene

Genes around OR2J3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2J3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2J3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2J3 Gene

  • Protein details for OR2J3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2J3
    Protein Accession:
    Secondary Accessions:
    • B0UY52
    • B9EH11
    • Q5SUJ7
    • Q6IF25
    • Q96R15
    • Q9GZK5
    • Q9GZL4
    • Q9GZL5

    Protein attributes for OR2J3 Gene

    311 amino acids
    Molecular mass:
    34950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J3 Gene

Post-translational modifications for OR2J3 Gene

Other Protein References for OR2J3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2J3 Gene

Domains & Families for OR2J3 Gene

Gene Families for OR2J3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2J3 Gene

Suggested Antigen Peptide Sequences for OR2J3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J3: view

Function for OR2J3 Gene

Molecular function for OR2J3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as green grassy or the smell of cut grass.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily J,member 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2J3 Gene

Gene Ontology (GO) - Molecular Function for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2J3: view
genes like me logo Genes that share phenotypes with OR2J3: view

Animal Model Products

miRNA for OR2J3 Gene

miRTarBase miRNAs that target OR2J3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2J3 Gene

Localization for OR2J3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2J3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2J3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2J3 Gene

Pathways & Interactions for OR2J3 Gene

genes like me logo Genes that share pathways with OR2J3: view

Pathways by source for OR2J3 Gene

1 KEGG pathway for OR2J3 Gene

Interacting Proteins for OR2J3 Gene

Gene Ontology (GO) - Biological Process for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J3: view

No data available for SIGNOR curated interactions for OR2J3 Gene

Drugs & Compounds for OR2J3 Gene

No Compound Related Data Available

Transcripts for OR2J3 Gene

mRNA/cDNA for OR2J3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2J3 Gene

Olfactory receptor, family 2, subfamily J, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J3 Gene

No ASD Table

Relevant External Links for OR2J3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2J3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2J3 Gene

mRNA differential expression in normal tissues according to GTEx for OR2J3 Gene

This gene is overexpressed in Testis (x31.4).

NURSA nuclear receptor signaling pathways regulating expression of OR2J3 Gene:


SOURCE GeneReport for Unigene cluster for OR2J3 Gene:

genes like me logo Genes that share expression patterns with OR2J3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2J3 Gene

Orthologs for OR2J3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC471931 33
  • 99.04 (n)
OR2J3 34
  • 98 (a)
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
-- 34
  • 88 (a)
OR2J3 33
  • 87.59 (n)
-- 34
  • 87 (a)
-- 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
(Mus musculus)
Mammalia Olfr1381 34
  • 56 (a)
Or2j3 51 Olfr137
  • chr17:38,304,524-38,305,459
Species where no ortholog for OR2J3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2J3 Gene

Gene Tree for OR2J3 (if available)
Gene Tree for OR2J3 (if available)
Evolutionary constrained regions (ECRs) for OR2J3: view image

Paralogs for OR2J3 Gene

(445) SIMAP similar genes for OR2J3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2J3: view

Variants for OR2J3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J3 Gene

Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIM:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.

Sequence variations from dbSNP and Humsavar for OR2J3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs28757581 affects, C3HEX, ability to smell 29,112,227(+) A/G coding_sequence_variant, missense_variant
rs3749977 affects, C3HEX, ability to smell 29,112,567(+) G/A coding_sequence_variant, missense_variant
rs1000383614 -- 29,109,935(+) A/G upstream_transcript_variant
rs1000811264 -- 29,111,622(+) A/G upstream_transcript_variant
rs1002394973 -- 29,112,917(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2J3 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
dgv1172e214 CNV gain 21293372
dgv1173e214 CNV loss 21293372
esv2763545 CNV loss 21179565
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074388 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv428138 CNV gain+loss 18775914
nsv601216 CNV gain 21841781
nsv830623 CNV gain 17160897
nsv970098 CNV duplication 23825009

Variation tolerance for OR2J3 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2J3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for OR2J3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR2J3 Gene - From: HGMD, OMIM, GTR, and GeneCards

Disorder Aliases PubMed IDs
c3hex, ability to smell
- elite association - COSMIC cancer census association via MalaCards
Search OR2J3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR2J3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OR2J3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2J3 Gene

Publications for OR2J3 Gene

  1. Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. (PMID: 22714804) McRae JF … Newcomb RD (Chemical senses 2012) 3 4 58
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 44 58
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for OR2J3 Gene

Sources for OR2J3 Gene

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