Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a ... See more...
Aliases for OR2J3 Gene
Aliases for OR2J3 Gene
External Ids for OR2J3 Gene
Previous GeneCards Identifiers for OR2J3 Gene
- GC06U990203
- GC06P029188
- GC06P029079
- GC06P028887
- GC06P029112
Summaries for OR2J3 Gene
-
This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]
GeneCards Summary for OR2J3 Gene
OR2J3 (Olfactory Receptor Family 2 Subfamily J Member 3) is a Protein Coding gene. Diseases associated with OR2J3 include C3hex, Ability To Smell. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.
UniProtKB/Swiss-Prot Summary for OR2J3 Gene
-
Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.
Additional gene information for OR2J3 Gene
- HGNC(8261)
- Entrez Gene(442186)
- Ensembl(ENSG00000204701)
- OMIM(615016)
- UniProtKB(O76001)
- Open Targets Platform(ENSG00000204701)
- Search for OR2J3 at DataMed
- Search for OR2J3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2J3 Gene
Genomics for OR2J3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for OR2J3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J028814 | Enhancer | 0.8 | FANTOM5 | 2.9 | -293.7 | -293681 | 0.1 | PRDM10 ZNF629 IKZF1 ZNF692 PRDM1 ZSCAN4 POLR2A PATZ1 ZNF501 EZH2 | ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3 OR2B3 | |
| GH06J029467 | Enhancer | 0.2 | FANTOM5 | 6.4 | +359.6 | 359640 | 0.3 | OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1 | ||
| GH06J028854 | Enhancer | 0.5 | FANTOM5 | 2.2 | -253.2 | -253175 | 0.2 | HDAC2 FOXA2 ZMYM3 KDM1A | HCG14 TRIM27 HCG15 ENSG00000244349 ZNF602P OR2J3 OR2B3 OR14J1 RPL13P piR-55194-322 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around OR2J3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2J3
- Top Transcription factor binding sites by QIAGEN in the OR2J3 gene promoter:
-
- CREB
- deltaCREB
- FOXO3
- FOXO3a
- FOXO3b
- GR
- GR-alpha
- GR-beta
- Nkx3-1
- Nkx3-1 v1
Genomic Locations for OR2J3 Gene
Genomic Locations for OR2J3 Gene
- chr6:29,108,059-29,114,770
- (GRCh38/hg38)
- Size:
- 6,712 bases
- Orientation:
- Plus strand
- chr6:29,079,668-29,080,603
- (GRCh37/hg19)
- Size:
- 936 bases
- Orientation:
- Plus strand
Genomic View for OR2J3 Gene
Genes around OR2J3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
OR2J3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OR2J3 Gene
Proteins for OR2J3 Gene
-
Protein details for OR2J3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O76001-OR2J3_HUMAN
- Recommended name:
- Olfactory receptor 2J3
- Protein Accession:
- O76001
- B0UY52
- B9EH11
- Q5SUJ7
- Q6IF25
- Q96R15
- Q9GZK5
- Q9GZL4
- Q9GZL5
Protein attributes for OR2J3 Gene
- Size:
- 311 amino acids
- Molecular mass:
- 34950 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for OR2J3 Gene
-
Glycosylation at Asn8
- NX_O76001 (NX_O76001-1)
Other Protein References for OR2J3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
- HORDE protein sequence:
Antibody Products
- G Biosciences Immunotag™ Olfactory receptor 2J3 Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for OR2J3
- Invitrogen Antibodies for OR2J3 (AFLGC-OR2J3)
-
Biorbyt antibodies for OR2J3
-
Boster Bio Antibodies for OR2J3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OR2J3
- Origene Custom Protein Services for OR2J3
Assay Products
No data available for DME Specific Peptides for OR2J3 Gene
Domains & Families for OR2J3 Gene
Gene Families for OR2J3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for OR2J3 Gene
- InterPro:
- Blocks:
-
- Olfactory receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for OR2J3 Gene
- GenScript: Design optimal peptide antigens:
-
- Olfactory receptor, family 2, subfamily J, member 3 (B0UY52_HUMAN)
- Olfactory receptor OR6-16 (OR2J3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O76001- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for OR2J3 Gene
Molecular function for OR2J3 Gene
- UniProtKB/Swiss-Prot Function:
- Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.
- GENATLAS Biochemistry:
- olfactory receptor,family 2,subfamily J,member 3,G protein coupled receptor superfamily
Phenotypes From GWAS Catalog for OR2J3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA | -- |
| GO:0004984 | olfactory receptor activity | IEA | -- |
Phenotypes for OR2J3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OR2J3 - Select products 50% OFF >
- * OR2J3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OR2J3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OR2J3
-
Santa Cruz Biotechnology (SCBT) CRISPR for OR2J3
miRNA for OR2J3 Gene
- miRTarBase miRNAs that target OR2J3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OR2J3
- Browse OriGene Inhibitory RNA Products For OR2J3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J3
Clone Products
- Applied Biological Materials (abm): Clones for OR2J3 - Select products 50% OFF >
- * OR2J3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OR2J3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OR2J3
Cell Line Products
-
Horizon Cell Lines for OR2J3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2J3 Gene
Localization for OR2J3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OR2J3 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2J3 Gene
Pathways & Interactions for OR2J3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Olfactory transduction | ||
| 3 | Peptide ligand-binding receptors | ||
Pathways by source for OR2J3 Gene
1 BioSystems pathway for OR2J3 Gene
4 Reactome pathways for OR2J3 Gene
1 KEGG pathway for OR2J3 Gene
Interacting Proteins for OR2J3 Gene
GPS-Prot Interaction Network for OR2J3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0007608 | sensory perception of smell | IEA | -- |
| GO:0050896 | response to stimulus | IEA | -- |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
No data available for SIGNOR curated interactions for OR2J3 Gene
Transcripts for OR2J3 Gene
mRNA/cDNA for OR2J3 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377169 1325 nts (view in UCSC)
- ENST00000641151 3297 nts (view in UCSC)
- ENST00000641960 3342 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OR2J3 - Select products 50% OFF >
- * OR2J3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OR2J3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OR2J3
-
Santa Cruz Biotechnology (SCBT) CRISPR for OR2J3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OR2J3
- Browse OriGene Inhibitory RNA Products For OR2J3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J3
Clone Products
- Applied Biological Materials (abm): Clones for OR2J3 - Select products 50% OFF >
- * OR2J3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OR2J3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OR2J3
Relevant External Links for OR2J3 Gene
- GeneLoc Exon Structure for
- OR2J3
Expression for OR2J3 Gene
mRNA differential expression in normal tissues according to GTEx for OR2J3 Gene
This gene is overexpressed in Testis (x31.4).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2J3
SOURCE GeneReport for Unigene cluster for OR2J3 Gene:
Hs.738947Primer Products
-
OriGene qPCR primer pairs for OR2J3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2J3 Gene
Orthologs for OR2J3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC471931 30 |
|
||
| OR2J3 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| OR2J3 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Olfr1381 31 |
|
ManyToMany | |
| Or2j3 46 Olfr137 |
|
|
- Species where no ortholog for OR2J3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for OR2J3 Gene
- ENSEMBL:
- Gene Tree for OR2J3 (if available)
- TreeFam:
- Gene Tree for OR2J3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OR2J3: view image
Paralogs for OR2J3 Gene
Paralogs for OR2J3 Gene
- OR2J1 5
- OR2J2 5
- OR2B2 5
- OR2B6 5
- OR2G3 5
- OR2C3 5
- GCSAML-AS1 5
- OR2W3 5
- OR2H1 5
- OR2H2 5
- OR2G2 5
- OR2W1 5
- OR2B3 5
- OR2C1 5
- OR2Y1 5
- OR2G6 5
- OR2B11 5
- OR2I1P 5
- OR2K2 5
- OR2D3 5
- OR13C3 5
- OR13C4 5
- OR13C9 5
- OR13D1 5
- OR10A7 5
- OR2F1 5
- OR13C8 5
- OR13C5 5
- OR13C2 5
- OR2S2 5
- OR2D2 5
- OR10A6 5
- OR2F2 5
- OR5V1 5
- OR13J1 5
- OR10A4 5
- OR10A3 5
- OR10P1 5
- OR2AK2 5
- OR13H1 5
- OR10A5 5
- OR2Z1 5
- OR2V1 5
- OR10G6 5
- OR2L8 5
- OR2L5 5
- OR2L3 5
- OR2M2 5
- OR2T11 5
- OR2T27 5
- OR10C1 5
- OR10G2 5
- OR10S1 5
- OR10G4 5
- OR10G9 5
- OR10G8 5
- OR10D3 5
- OR2T8 5
- OR2AJ1 5
- OR2L2 5
- OR2M5 5
- OR2M3 5
- OR2T33 5
- OR2M7 5
- OR6B1 5
- OR10AG1 5
- OR2AE1 5
- OR10A2 5
- OR2V2 5
- OR10G7 5
- OR2T12 5
- OR2T4 5
- OR2T1 5
- OR2T3 5
- OR2T34 5
- OR2T35 5
- OR10H1 5
- OR10G3 5
- OR6A2 5
- OR2M4 5
- OR2T2 5
- OR2T5 5
- OR2T29 5
- OR2T10 5
- OR10H2 5
- OR10H5 5
- OR2T6 5
- OR2AG2 5
- OR2AG1 5
- OR6Y1 5
- OR2L13 5
- OR10AD1 5
- OR13C7 5
(445) SIMAP similar genes for OR2J3 Gene using alignment to 1 proteins:
- OR2J3_HUMAN
- OR2J4P
- OR2J1
- OR2J2
- OR2W6P
- OLFR 42A
- OR2C3
- OR2B8P
- OR2B2
- OR2G6
- 6M1-16
- OR2G3
- OR2Y1
- OR2G2
- OR2C1
- OR2H1
- OR2W1
- OR2H2
- OR2B6
- OR2B3
- OR2W3
- OR2B11
- OR2K2
- OR2H5P
- OR2A12
- olfr89
- OR4Q2
- OR2A2
- OR13C3
- OLFR 42B
- OR5B21
- OR2W5
- OR2D2
- OR2A5
- OR13F1
- OR13C9
- OR13C2
- OR10R3P
- OR10G2
- OR10A7
- OR5V1
- OR7A10
- OR5M11
- OR4Q3
- OR4E1
- OR2F1
- OR2D3
- OR2AJ1
- OR13D1
- OR2F2
- OR2A1
- OR7G3
- OR7-139
- OR5B2
- OR5AR1
- OR5AP2
- OR5A2
- OR4S2
- OR4M1
- OR2V1
- OR2T33
- OR2S2
- OR2I1P
- OR2A42
- OR2A14
- OR13C8
- OR13C5
- OR13C4
- OR10G9
- OR10G7
- OR10G4
- OR10A4
- OR12D3
- OR9Q2
- OR9Q1
- OR8G5
- OR8G1
- OR8D1
- OR8B8
- OR8B3
- OR8A1
- OR7D4
- OR7D2
- OR7A17
- OR7-140
- OR6N1
- OR5B3
- OR5B12
- OR5AS1
- OR4N5
- OR4N2
- OR4L1
- OR4K2
- OR4D5
- OR4D2
- OR4D1
- OR4C3
- OR2T8
- OR2T12
- OR2L8
- OR2L3
- OR2L2
- OR2AK2
- OR2A25
- OR1M1
- OR1J4
- OR1J1
- OR1D2
- OR13H1
- OR13G1
- OR13A1
- OR12D2
- OR10T2
- OR10R2
- OR10P1
- OR10G6
- OR10A5
- OR8G2
- OR4F3
- OR4F29
- OR4F16
- OR8J1
- OR8I2
- OR8B2
- OR8B12
- OR7G2
- OR7E86P
- OR7C2
- OR7C1
- OR7A2P
- OR6N2
- OR6C6
- OR6B3
- OR6B1
- OR5T1
- OR5M10
- OR5M1
- OR5K1
- OR5I1
- OR5G3
- OR5F1
- OR5D18
- OR5AU1
- OR5A1
- OR4N4
- OR4M2
- OR4K5
- OR4K17
- OR4K13
- OR4F6
- OR4F21
- OR4E2
- OR4C12
- OR4B1
- OR4A4P
- OR2V2
- OR2T7
- OR2T35
- OR2T27
- OR2T2
- OR2M7
- OR2M4
- OR2M2
- OR2L5
- OR2AP1
- OR2AG2
- OR2AG1
- OR2AE1
- OR2A7
- OR1G1
- OR1F1
- OR1E1
- OR11H7
- OR10Z1
- OR10Q1
- OR10J4
- OR10H2
- OR10G3
- OR10D3
- OR10AG1
- OR10A3
- OR10A2
- OR2A4
- OR11A1
- OR7A5
- OR4A47
- OR9I1
- OR9G4
- OR8U9
- OR8J2
- OR8D2
- OR6C74
- OR6B2
- OR5W2
- OR5T3
- OR5T2
- OR5M8
- OR5L2
- OR5H2
- OR5D16
- OR5C1
- OR5B17
- OR5AN1
- OR4S1
- OR4K3
- OR4K15
- OR4K1
- OR4F5
- OR4F4
- OR4F17
- OR4D10
- OR4C15
- OR4C13
- OR4A8P
- OR4A15
- OR3A3
- OR2Z1
- OR2T34
- OR2T3
- OR2T11
- OR2T1
- OR2M5
- OR1S2
- OR1S1
- OR1J2
- OR1F2P
- OR1F12
- OR1E3P
- OR1E2
- OR1D5
- OR1C1
- OR1A1
- OR17-16
- OR17-137
- OR11L1
- OR11H6
- OR11H4
- OR11G2
- OR10W1
- OR10G8
- OR10D4P
- OR10A6
- OR14J1
- OR10C1
- OR4A5
- OR8U8
- OR8U1
- OR8J3
- OR8H3
- OR8H1
- OR8B4
- OR7G1
- OR7E85P
- OR6X1
- OR6J1
- OR6F1
- OR6C70
- OR6C2
- OR6C1
- OR5M9
- OR5M3
- OR5L1
- OR5K3
- OR5K2
- OR5AL1
- OR5AK3P
- OR5AC1
- OR4P4
- OR4K14
- OR4F15
- OR4D9
- OR4D11
- OR4C46
- OR3A2
- OR2T5
- OR2T4
- OR2T29
- OR2T10
- OR2M3
- OR1N2
- OR1L8
- OR1K1
- OR1E3
- OR1D4
- OR1A2
- OR17-130
- OR16-89
- OR14A2
- OR14A16
- OR13J1
- OR10V1
- OR10S1
- OR10K1
- OR10J1
- OR10H5
- OR10H3
- OR10H1
- HSA12
- OR10J5
- OR9K2
- OR9G9
- OR9G1
- OR8K3
- OR8H2
- OR8D4
- OR7E24
- OR6Y1
- OR6S1
- OR6P1
- OR6M1
- OR6C75
- OR6C68
- OR6C65
- OR6C3
- OR6A2
- OR5R1
- OR5P2
- OR5K4
- OR5H6
- OR5AK2
- OR4X1
- OR4C11
- OR3A1
- OR2L13
- OR1Q1
- OR1P1
- OR1N1
- OR1L6
- OR1L4
- OR1L1
- OR17-15
- OR16-90
- OR16-88
- OR16-37
- OR16-36
- OR14L1P
- OR11H2
- OR11H12
- OR11H1
- OR10X1
- OR10H4
- HSA10
- OR6Q1
- OR5H14
- OR8S1
- OR7E5P
- OR6V1
- OR6T1
- OR6C76
- OR6C4
- OR5J2
- OR5H15
- OR5H1
- OR5E1P
- OR5D14
- OR5D13
- OR4X2
- OR4C6
- OR4A16
- OR2T6
- OR1L3
- OR10J3
- OR10AD1
- JCG4
- OR10K2
- OR9A4
- PJCG1
- OR8K1
- OR7E35P
- OR5P3
- OR5D3
- OR5AC2
- OR4D6
- OR4C5
- OR4C45
- OR3A4P
- OR1B1
- OR14I1
- OR14C36
- OR10AC1P
- OR8K5
- OR6K6
- OR6K3
- OR6K2
- OR4C16
- OR1I1
- OR11H13P
- OR14K1
- OR10J6P
- OR9A2
- OR52E8
- OR9A1P
- OR52L2P
- OR52E4
- OR52D1
- OR52B2
- OR52Z1
- OR52N5
- OR52K1
- OR52J3
- OR52I2
- OR52E6
- OR52I1
- OR56A5
- OR56A4
- OR56A3
- OR56A1
- OR52R1
- OR52L1
- OR52K2
- OR52H1
- OR52E1
- OR2AT4
- OR51M1
- OR56B4
- OR52P1P
- OR52N4
- OR52N2
- OR51T1
- OR51E2
- OR51E1
- OR51A2
- OR56B2P
- OR52W1
- OR52N1
- OR52M1
- OR52E5
- OR52E2
- OR52B6
- OR51L1
- OR51G2
- OR51D1
- OR51B6
- OR51B5
- OR56B1
- OR51Q1
- OR51I1
- OR51H1P
- OR51B4
- OR51B2
- OR51A4
- OR51V1
- OR51S1
- OR51I2
- OR51G1
- OR51F2
Variants for OR2J3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J3 Gene
- OR2J3_HUMAN-O76001
- Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIM:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2J3 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs28757581 | Affects: C3HEX, ability to smell. - | 29,112,227(+) | A/Gp.Thr113Ala | MISSENSE_VARIANT | |
| rs3749977 | Affects: C3HEX, ability to smell. - | 29,112,567(+) | G/Ap.Arg226Gln | MISSENSE_VARIANT | |
| rs3130764 | - | p.Val228Ile | |||
| rs3130765 | - | p.Ile261Met |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10338n54 | CNV | gain | 21841781 |
| dgv1172e214 | CNV | gain | 21293372 |
| dgv1173e214 | CNV | loss | 21293372 |
| esv2763545 | CNV | loss | 21179565 |
| nsv1015796 | CNV | gain | 25217958 |
| nsv1032468 | CNV | loss | 25217958 |
| nsv1074388 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1145096 | CNV | deletion | 24896259 |
| nsv428138 | CNV | gain+loss | 18775914 |
| nsv601216 | CNV | gain | 21841781 |
| nsv830623 | CNV | gain | 17160897 |
| nsv970098 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.07;
75.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OR2J3 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for OR2J3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| c3hex, ability to smell |
|
|
Search OR2J3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for OR2J3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for OR2J3 Gene
Publications for OR2J3 Gene
- Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. (PMID: 22714804) McRae JF … Newcomb RD (Chemical senses 2012) 3 4
- Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 41
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
- The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
ExternalLinks
Products for OR2J3 Gene
- Custom Antibody ServicesOriGene Antibodies for OR2J3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OR2J3
- Origene Custom Protein Services for OR2J3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OR2J3
- Browse OriGene Inhibitory RNA Products For OR2J3
- OriGene qPCR primer pairs for OR2J3
- OriGene CRISPR knockouts for OR2J3
- OriGene ORF clones in human for OR2J3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For OR2J3
- Sino Biological Human cDNA Clone for OR2J3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for OR2J3 (AFLGC-OR2J3)
- VectorBuilder Custom and pre-made DNA vectors for OR2J3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for OR2J3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for OR2J3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for OR2J3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for OR2J3
- antibodies-online: Show 12 available OR2J3 Antibodies ranked by validation data
- Compare Top OR2J3 Antibodies
- antibodies-online: Show 10 available OR2J3 Elisa Kits ranked by validation data
- Compare Top OR2J3 Elisa Kits
- antibodies-online: Search results for available OR2J3 related products ranked by validation data
- Horizon Cell Lines for OR2J3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OR2J3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OR2J3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for OR2J3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J3
- Boster Bio Antibodies for OR2J3
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for OR2J3
Sources for OR2J3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB