This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a ... See more...

Aliases for OR2J3 Gene

Aliases for OR2J3 Gene

  • Olfactory Receptor Family 2 Subfamily J Member 3 2 3 5
  • OR6-6 2 3 4
  • Olfactory Receptor OR6-16 3 4
  • Olfactory Receptor 2J3 3 4
  • Olfactory Receptor 6-6 3 4
  • Olfactory Receptor, Family 2, Subfamily J, Member 3 2
  • HS6M1-3 3
  • OR6.3.6 3
  • Hs6M1-3 4
  • C3HEXS 3
  • OR6-16 3
  • ORL671 3
  • 6M1-3 3
  • OR2J3 5

External Ids for OR2J3 Gene

Previous GeneCards Identifiers for OR2J3 Gene

  • GC06U990203
  • GC06P029188
  • GC06P029079
  • GC06P028887
  • GC06P029112
  • GC06P029117
  • GC06P049159

Summaries for OR2J3 Gene

Entrez Gene Summary for OR2J3 Gene

  • This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]

GeneCards Summary for OR2J3 Gene

OR2J3 (Olfactory Receptor Family 2 Subfamily J Member 3) is a Protein Coding gene. Diseases associated with OR2J3 include C3hex, Ability To Smell and Retinal Arteries, Tortuosity Of. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.

UniProtKB/Swiss-Prot Summary for OR2J3 Gene

  • Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.

Gene Wiki entry for OR2J3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2J3 Gene

Genomics for OR2J3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2J3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J028814 Enhancer 0.8 FANTOM5 2.9 -293.7 -293680 0.1 IKZF1 ZNF600 ZNF580 ETS1 ZNF639 KLF7 ZNF610 SP2 GABPB1 ZNF843 HSALNG0049006-002 ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3
GH06J029467 Enhancer 0.2 FANTOM5 6.4 +359.6 359641 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06J028854 Enhancer 0.5 FANTOM5 2.2 -253.2 -253174 0.2 FOXA2 HDAC2 ZMYM3 KDM1A HCG14 TRIM27 HCG15 ENSG00000244349 ZNF602P OR2J3 OR2B3 OR14J1 RPL13P piR-55194-322
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2J3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2J3

Top Transcription factor binding sites by QIAGEN in the OR2J3 gene promoter:
  • CREB
  • deltaCREB
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GR
  • GR-alpha
  • GR-beta
  • Nkx3-1
  • Nkx3-1 v1

Genomic Locations for OR2J3 Gene

Latest Assembly
chr6:29,108,058-29,114,770
(GRCh38/hg38)
Size:
6,713 bases
Orientation:
Plus strand

Previous Assembly
chr6:29,075,835-29,082,547
(GRCh37/hg19 by Entrez Gene)
Size:
6,713 bases
Orientation:
Plus strand

chr6:29,079,668-29,080,603
(GRCh37/hg19 by Ensembl)
Size:
936 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_1):373,686-380,389 (+)
  • chr6(ALT_REF_LOCI_2):594,602-601,315 (+)
  • chr6(ALT_REF_LOCI_3):373,664-380,371 (+)
  • chr6(ALT_REF_LOCI_4):373,621-380,329 (+)
  • chr6(ALT_REF_LOCI_5):373,805-378,403 (+)
  • chr6(ALT_REF_LOCI_6):373,643-380,354 (+)
  • chr6(ALT_REF_LOCI_7):417,426-424,133 (+)

Genomic View for OR2J3 Gene

Genes around OR2J3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2J3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2J3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2J3 Gene

  • Protein details for OR2J3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76001-OR2J3_HUMAN
    Recommended name:
    Olfactory receptor 2J3
    Protein Accession:
    O76001
    Secondary Accessions:
    • B0UY52
    • B9EH11
    • Q5SUJ7
    • Q6IF25
    • Q96R15
    • Q9GZK5
    • Q9GZL4
    • Q9GZL5

    Protein attributes for OR2J3 Gene

    Size:
    311 amino acids
    Molecular mass:
    34950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J3 Gene

Post-translational modifications for OR2J3 Gene

  • Glycosylation at Asn8

Other Protein References for OR2J3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2J3 Gene

Domains & Families for OR2J3 Gene

Gene Families for OR2J3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2J3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2J3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 2, subfamily J, member 3 (B0UY52_HUMAN)
  • Olfactory receptor OR6-16 (OR2J3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76001

UniProtKB/Swiss-Prot:

OR2J3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J3: view

Function for OR2J3 Gene

Molecular function for OR2J3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily J,member 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2J3 Gene

Gene Ontology (GO) - Molecular Function for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2J3: view
genes like me logo Genes that share phenotypes with OR2J3: view

miRNA for OR2J3 Gene

miRTarBase miRNAs that target OR2J3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2J3 Gene

Localization for OR2J3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2J3 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2J3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2J3 Gene

Pathways & Interactions for OR2J3 Gene

genes like me logo Genes that share pathways with OR2J3: view

Pathways by source for OR2J3 Gene

1 KEGG pathway for OR2J3 Gene

Interacting Proteins for OR2J3 Gene

Gene Ontology (GO) - Biological Process for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J3: view

No data available for SIGNOR curated interactions for OR2J3 Gene

Drugs & Compounds for OR2J3 Gene

No Compound Related Data Available

Transcripts for OR2J3 Gene

mRNA/cDNA for OR2J3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J3

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J3 Gene

No ASD Table

Relevant External Links for OR2J3 Gene

GeneLoc Exon Structure for
OR2J3

Expression for OR2J3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2J3 Gene

mRNA differential expression in normal tissues according to GTEx for OR2J3 Gene

This gene is overexpressed in Testis (x31.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2J3

SOURCE GeneReport for Unigene cluster for OR2J3 Gene:

Hs.738947
genes like me logo Genes that share expression patterns with OR2J3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2J3 Gene

Orthologs for OR2J3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471931 29
  • 99.04 (n)
OR2J3 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 88 (a)
OneToMany
-- 30
  • 88 (a)
OneToMany
OR2J3 29
  • 87.59 (n)
-- 30
  • 87 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 60 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr1381 30
  • 56 (a)
ManyToMany
Or2j3 45 Olfr137
  • chr17:38,304,524-38,305,459
Species where no ortholog for OR2J3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2J3 Gene

ENSEMBL:
Gene Tree for OR2J3 (if available)
TreeFam:
Gene Tree for OR2J3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2J3: view image
Alliance of Genome Resources:
Additional Orthologs for OR2J3

Paralogs for OR2J3 Gene

(445) SIMAP similar genes for OR2J3 Gene using alignment to 1 proteins:

  • OR2J3_HUMAN
genes like me logo Genes that share paralogs with OR2J3: view

Variants for OR2J3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J3 Gene

OR2J3_HUMAN-O76001
Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIM:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2J3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs28757581 Affects: C3HEX, ability to smell 29,112,227(+) A/Gp.Thr113Ala
NM_001005216.3(OR2J3):c.337A>G (p.Thr113Ala)
MISSENSE
rs3749977 Affects: C3HEX, ability to smell 29,112,567(+) G/Ap.Arg226Gln
NM_001005216.3(OR2J3):c.677G>A (p.Arg226Gln)
MISSENSE
rs3130764 -- p.Val228Ile
rs3130765 -- p.Ile261Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2J3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2J3 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
dgv1172e214 CNV gain 21293372
dgv1173e214 CNV loss 21293372
esv2763545 CNV loss 21179565
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074388 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv428138 CNV gain+loss 18775914
nsv601216 CNV gain 21841781
nsv830623 CNV gain 17160897
nsv970098 CNV duplication 23825009

Variation tolerance for OR2J3 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2J3 Gene

Human Gene Mutation Database (HGMD)
OR2J3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2J3
Leiden Open Variation Database (LOVD)
OR2J3

SNP Genotyping and Copy Number Assays for research

Disorders for OR2J3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR2J3 Gene - From: OMI, GTR, COP, and GCD

Disorder Aliases PubMed IDs
c3hex, ability to smell
retinal arteries, tortuosity of
  • rator
- elite association - COSMIC cancer census association via MalaCards
Search OR2J3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR2J3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR2J3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2J3 Gene

Publications for OR2J3 Gene

  1. Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. (PMID: 22714804) McRae JF … Newcomb RD (Chemical senses 2012) 3 4
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 40
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 40
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for OR2J3 Gene

Sources for OR2J3 Gene