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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR2J2 (Olfactory Receptor Family 2 Subfamily J Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J029235 | Enhancer | 0.5 | Ensembl | 0.2 | +65.3 | 65294 | 2 | ZNF316 FOXA2 MAFF MAFK YY1 MAFG EMSY | TRIM27 TRIM26 HLA-A HLA-U LOC105375006 lnc-OR2J2-3 piR-37972-588 ENSG00000197171 LOC101929006 OR14J1 | |
GH06J029226 | Enhancer | 0.2 | Ensembl | 0.2 | +55.4 | 55394 | 0.6 | TRIM27 OR2W1 OR14J1 MICD ENSG00000197171 LOC101929006 OR2G1P OR2J2 | ||
GH06J029294 | Enhancer | 0.3 | Ensembl | 0.1 | +123.4 | 123394 | 0.2 | CTCF | TRIM26 OR2B4P OR14J1 MN309174-567 LOC105375005 OR2J2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC740101 30 |
|
||
OR2J2 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
LOC789358 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Olfr137 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10338n54 | CNV | gain | 21841781 |
dgv1172e214 | CNV | gain | 21293372 |
dgv1173e214 | CNV | loss | 21293372 |
dgv1722e212 | CNV | loss | 25503493 |
dgv1723e212 | CNV | gain | 25503493 |
esv27226 | CNV | loss | 19812545 |
esv2731758 | CNV | deletion | 23290073 |
esv2763545 | CNV | loss | 21179565 |
esv3608473 | CNV | gain | 21293372 |
esv3890805 | CNV | loss | 25118596 |
nsv1015796 | CNV | gain | 25217958 |
nsv1032468 | CNV | loss | 25217958 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1145096 | CNV | deletion | 24896259 |
nsv428138 | CNV | gain+loss | 18775914 |
nsv462670 | CNV | loss | 19166990 |
nsv517415 | CNV | loss | 19592680 |
nsv526153 | CNV | loss | 19592680 |
nsv601216 | CNV | gain | 21841781 |
nsv823468 | CNV | loss | 20364138 |
nsv830623 | CNV | gain | 17160897 |
nsv965701 | CNV | duplication | 23825009 |
No disorders were found for OR2J2 Gene.