Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2J2 Gene

Aliases for OR2J2 Gene

  • Olfactory Receptor Family 2 Subfamily J Member 2 2 3 5
  • Hs6M1-6 2 3 4
  • OR6-8 2 3 4
  • Olfactory Receptor OR6-19 3 4
  • Olfactory Receptor 2J2 3 4
  • Olfactory Receptor 6-8 3 4
  • DJ80I19.4 2 3
  • Olfactory Receptor, Family 2, Subfamily J, Member 2 2
  • OR6.3.8 3
  • OR6-19 3
  • ORL684 3
  • OR2J2 5

External Ids for OR2J2 Gene

Previous GeneCards Identifiers for OR2J2 Gene

  • GC06P029198
  • GC06P028912
  • GC06P029249
  • GC06P029141
  • GC06P028948
  • GC06P029179
  • GC06P029182

Summaries for OR2J2 Gene

Entrez Gene Summary for OR2J2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2J2 Gene

OR2J2 (Olfactory Receptor Family 2 Subfamily J Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.

UniProtKB/Swiss-Prot Summary for OR2J2 Gene

Gene Wiki entry for OR2J2 Gene

Additional gene information for OR2J2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2J2 Gene

Genomics for OR2J2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2J2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029235 Enhancer 0.5 Ensembl 0.2 +65.3 65294 2 ZNF316 FOXA2 MAFF MAFK YY1 MAFG EMSY TRIM27 TRIM26 HLA-A HLA-U LOC105375006 lnc-OR2J2-3 piR-37972-588 ENSG00000197171 LOC101929006 OR14J1
GH06J029226 Enhancer 0.2 Ensembl 0.2 +55.4 55394 0.6 TRIM27 OR2W1 OR14J1 MICD ENSG00000197171 LOC101929006 OR2G1P OR2J2
GH06J029294 Enhancer 0.3 Ensembl 0.1 +123.4 123394 0.2 CTCF TRIM26 OR2B4P OR14J1 MN309174-567 LOC105375005 OR2J2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2J2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2J2

Top Transcription factor binding sites by QIAGEN in the OR2J2 gene promoter:
  • AML1a
  • FAC1
  • GR
  • GR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR2J2 Gene

Genomic Locations for OR2J2 Gene
chr6:29,170,907-29,175,811
(GRCh38/hg38)
Size:
4,905 bases
Orientation:
Plus strand
chr6:29,141,311-29,142,351
(GRCh37/hg19)
Size:
1,041 bases
Orientation:
Plus strand

Genomic View for OR2J2 Gene

Genes around OR2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2J2 Gene

  • Protein details for OR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76002-OR2J2_HUMAN
    Recommended name:
    Olfactory receptor 2J2
    Protein Accession:
    O76002
    Secondary Accessions:
    • A6NCU9
    • A6NLD0
    • B0UY53
    • Q32N09
    • Q5ST39
    • Q5SUJ6
    • Q6IF24
    • Q9GZK2
    • Q9GZL3

    Protein attributes for OR2J2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J2 Gene

Post-translational modifications for OR2J2 Gene

  • Glycosylation at Asn6

Other Protein References for OR2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2J2 Gene

Domains & Families for OR2J2 Gene

Gene Families for OR2J2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2J2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR2J2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR6-19 (OR2J2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76002

UniProtKB/Swiss-Prot:

OR2J2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J2: view

Function for OR2J2 Gene

Molecular function for OR2J2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily J,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2J2 Gene

Gene Ontology (GO) - Molecular Function for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2J2: view
genes like me logo Genes that share phenotypes with OR2J2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2J2 Gene

Localization for OR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2J2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2J2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2J2 Gene

Pathways & Interactions for OR2J2 Gene

genes like me logo Genes that share pathways with OR2J2: view

Pathways by source for OR2J2 Gene

1 KEGG pathway for OR2J2 Gene

Interacting Proteins for OR2J2 Gene

Gene Ontology (GO) - Biological Process for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J2: view

No data available for SIGNOR curated interactions for OR2J2 Gene

Drugs & Compounds for OR2J2 Gene

No Compound Related Data Available

Transcripts for OR2J2 Gene

mRNA/cDNA for OR2J2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2J2

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J2 Gene

No ASD Table

Relevant External Links for OR2J2 Gene

GeneLoc Exon Structure for
OR2J2

Expression for OR2J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR2J2 Gene

This gene is overexpressed in Testis (x26.7), Brain - Caudate (basal ganglia) (x4.5), and Brain - Hypothalamus (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2J2

SOURCE GeneReport for Unigene cluster for OR2J2 Gene:

Hs.163518
genes like me logo Genes that share expression patterns with OR2J2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2J2 Gene

Orthologs for OR2J2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC740101 30
  • 99.04 (n)
OR2J2 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 86 (a)
OneToMany
LOC789358 30
  • 85.96 (n)
Mouse
(Mus musculus)
Mammalia Olfr137 31
  • 80 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 60 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
ManyToMany
Species where no ortholog for OR2J2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2J2 Gene

ENSEMBL:
Gene Tree for OR2J2 (if available)
TreeFam:
Gene Tree for OR2J2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2J2: view image

Paralogs for OR2J2 Gene

(447) SIMAP similar genes for OR2J2 Gene using alignment to 1 proteins:

  • OR2J2_HUMAN
genes like me logo Genes that share paralogs with OR2J2: view

Variants for OR2J2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J2 Gene

OR2J2_HUMAN-O76002
Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2J2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs3116855 - p.His74Tyr
rs3116856 - p.Ala146Val
rs3129157 - p.Ala111Thr
rs3130743 - p.Ala218Thr

Additional dbSNP identifiers (rs#s) for OR2J2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2J2 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
dgv1172e214 CNV gain 21293372
dgv1173e214 CNV loss 21293372
dgv1722e212 CNV loss 25503493
dgv1723e212 CNV gain 25503493
esv27226 CNV loss 19812545
esv2731758 CNV deletion 23290073
esv2763545 CNV loss 21179565
esv3608473 CNV gain 21293372
esv3890805 CNV loss 25118596
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv428138 CNV gain+loss 18775914
nsv462670 CNV loss 19166990
nsv517415 CNV loss 19592680
nsv526153 CNV loss 19592680
nsv601216 CNV gain 21841781
nsv823468 CNV loss 20364138
nsv830623 CNV gain 17160897
nsv965701 CNV duplication 23825009

Variation tolerance for OR2J2 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.04; 97.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2J2 Gene

Human Gene Mutation Database (HGMD)
OR2J2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2J2

SNP Genotyping and Copy Number Assay Products

Disorders for OR2J2 Gene

Additional Disease Information for OR2J2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for OR2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2J2 Gene

Publications for OR2J2 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  5. Common variation contributes to the genetic architecture of social communication traits. (PMID: 24047820) St Pourcain B … Smith GD (Molecular autism 2013) 3

Products for OR2J2 Gene

Sources for OR2J2 Gene