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OR2J2 Gene(Protein Coding)

Olfactory Receptor Family 2 Subfamily J Member 2

GCID:
GC06P029170
GIFtS:
39
Genes Participants
UDN Logo

Aliases for OR2J2 Gene

Aliases for OR2J2 Gene

  • Olfactory Receptor Family 2 Subfamily J Member 2 2 3 5
  • Olfactory Receptor OR6-19 3 4
  • Olfactory Receptor 6-8 3 4
  • Hs6M1-6 3 4
  • OR6-8 3 4
  • Olfactory Receptor, Family 2, Subfamily J, Member 2 2
  • Olfactory Receptor 2J2 3
  • DJ80I19.4 3
  • OR6.3.8 3
  • OR6-19 3
  • ORL684 3

External Ids for OR2J2 Gene

Previous GeneCards Identifiers for OR2J2 Gene

  • GC06P029198
  • GC06P028912
  • GC06P029249
  • GC06P029141
  • GC06P028948
  • GC06P029179
  • GC06P029182

Summaries for OR2J2 Gene

Entrez Gene Summary for OR2J2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2J2 Gene

OR2J2 (Olfactory Receptor Family 2 Subfamily J Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.

UniProtKB/Swiss-Prot for OR2J2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2J2 Gene

Additional gene information for OR2J2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2J2 Gene

Genomics for OR2J2 Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OR2J2 Gene

Promoters and enhancers for OR2J2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J030065 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 +895.9 895898 3 ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC PPP1R11 TRIM39 ZNRD1 HCG4P3 TRIM26 PPP1R10 NRM MDC1 HLA-A RPL7P4
GH06J028586 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.6 -583.7 -583742 1.9 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 TRQ-TTG2-1 ZBED9 GPX6 GPX5 ZKSCAN3 ZNF311 ZNF603P ZSCAN12 ZNF90P2 KRT18P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2J2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2J2 gene promoter:
  • FAC1
  • GR
  • AML1a
  • GR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR2J2 Gene

Genomic Locations for OR2J2 Gene
chr6:29,170,907-29,175,811
(GRCh38/hg38)
Size:
4,905 bases
Orientation:
Plus strand
chr6:29,141,311-29,142,351
(GRCh37/hg19)
Size:
1,041 bases
Orientation:
Plus strand

Genomic View for OR2J2 Gene

Genes around OR2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2J2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR2J2 Gene

Proteins for OR2J2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76002-OR2J2_HUMAN
    Recommended name:
    Olfactory receptor 2J2
    Protein Accession:
    O76002
    Secondary Accessions:
    • A6NCU9
    • A6NLD0
    • B0UY53
    • Q32N09
    • Q5ST39
    • Q5SUJ6
    • Q6IF24
    • Q9GZK2
    • Q9GZL3

    Protein attributes for OR2J2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J2 Gene

Post-translational modifications for OR2J2 Gene

Other Protein References for OR2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2J2 Gene

Domains & Families for OR2J2 Gene

Gene Families for OR2J2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2J2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OR2J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76002

UniProtKB/Swiss-Prot:

OR2J2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J2: view

Function for OR2J2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OR2J2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily J,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2J2 Gene

Gene Ontology (GO) - Molecular Function for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2J2: view
genes like me logo Genes that share phenotypes with OR2J2: view

Animal Model Products

Clone Products

  • Addgene plasmids for OR2J2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2J2 Gene

Localization for OR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2J2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2J2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2J2 Gene

Pathways & Interactions for OR2J2 Gene

genes like me logo Genes that share pathways with OR2J2: view

Pathways by source for OR2J2 Gene

1 BioSystems pathway for OR2J2 Gene
1 KEGG pathway for OR2J2 Gene

Gene Ontology (GO) - Biological Process for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J2: view

No data available for SIGNOR curated interactions for OR2J2 Gene

Drugs & Compounds for OR2J2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR2J2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OR2J2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2J2 Gene

Olfactory receptor, family 2, subfamily J, member 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for OR2J2

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J2 Gene

No ASD Table

Relevant External Links for OR2J2 Gene

GeneLoc Exon Structure for
OR2J2
ECgene alternative splicing isoforms for
OR2J2

Expression for OR2J2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2J2 Gene

mRNA expression in normal human tissues for OR2J2 Gene
mRNA expression by BioGPS for OR2J2 GenemRNA expression by GTEx for OR2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR2J2 Gene

This gene is overexpressed in Testis (x26.7), Brain - Caudate (basal ganglia) (x4.5), and Brain - Hypothalamus (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of OR2J2 Gene:

OR2J2

SOURCE GeneReport for Unigene cluster for OR2J2 Gene:

Hs.163518
genes like me logo Genes that share expression patterns with OR2J2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2J2 Gene

Orthologs for OR2J2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC740101 33
  • 99.04 (n)
OR2J2 34
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia -- 34
  • 86 (a)
 OneToMany
LOC789358 33
  • 85.96 (n)
mouse
(Mus musculus)
 Mammalia Olfr137 34
  • 80 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 60 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 52 (a)
 ManyToMany
Species where no ortholog for OR2J2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2J2 Gene

ENSEMBL:
Gene Tree for OR2J2 (if available)
TreeFam:
Gene Tree for OR2J2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2J2: view image

Paralogs for OR2J2 Gene

Paralogs for OR2J2 Gene

(447) SIMAP similar genes for OR2J2 Gene using alignment to 1 proteins:

  • OR2J2_HUMAN
genes like me logo Genes that share paralogs with OR2J2: view

Variants for OR2J2 Gene

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  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J2 Gene

OR2J2_HUMAN-O76002
Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01.

Sequence variations from dbSNP and Humsavar for OR2J2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000209463 -- 29,172,258(+) A/T upstream_transcript_variant
rs1004741152 -- 29,173,197(+) A/T upstream_transcript_variant
rs1010374258 -- 29,172,211(+) C/A upstream_transcript_variant
rs1010731970 -- 29,171,833(+) C/A/T upstream_transcript_variant
rs1012737079 -- 29,174,867(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2J2 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
dgv1172e214 CNV gain 21293372
dgv1173e214 CNV loss 21293372
dgv1722e212 CNV loss 25503493
dgv1723e212 CNV gain 25503493
esv27226 CNV loss 19812545
esv2731758 CNV deletion 23290073
esv2763545 CNV loss 21179565
esv3608473 CNV gain 21293372
esv3890805 CNV loss 25118596
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv428138 CNV gain+loss 18775914
nsv462670 CNV loss 19166990
nsv517415 CNV loss 19592680
nsv526153 CNV loss 19592680
nsv601216 CNV gain 21841781
nsv823468 CNV loss 20364138
nsv830623 CNV gain 17160897
nsv965701 CNV duplication 23825009

Variation tolerance for OR2J2 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.04; 97.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2J2 Gene

Human Gene Mutation Database (HGMD)
OR2J2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2J2

SNP Genotyping and Copy Number Assay Products

Disorders for OR2J2 Gene

Additional Disease Information for OR2J2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2J2 Gene

Publications for OR2J2 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Common variation contributes to the genetic architecture of social communication traits. (PMID: 24047820) St Pourcain B … Smith GD (Molecular autism 2013) 3 58

Products for OR2J2 Gene

  • Addgene plasmids for OR2J2

Sources for OR2J2 Gene

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