Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2J1 Gene

Aliases for OR2J1 Gene

  • Olfactory Receptor Family 2 Subfamily J Member 1 2 3 5
  • Hs6M1-4 2 3 4
  • OR6-5 2 3 4
  • Olfactory Receptor, Family 2, Subfamily J, Member 1 Pseudogene 2 3
  • Olfactory Receptor 2J1 3 4
  • Olfactory Receptor 6-5 3 4
  • DJ80I19.2 2 3
  • OR2J1P 3 4
  • Olfactory Receptor, Family 2, Subfamily J, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 2 Subfamily J Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily J, Member 1 2
  • Olfactory Receptor OR6-15 3
  • 6M1-4P 3
  • OR6-15 3
  • OR2J1 5

External Ids for OR2J1 Gene

Previous HGNC Symbols for OR2J1 Gene

  • OR2J1P

Previous GeneCards Identifiers for OR2J1 Gene

  • GC06U900570
  • GC06P029176
  • GC06P029069
  • GC06P028876
  • GC06Pi29069
  • GC06P029070
  • GC06P029100
  • GC06P029103
  • GC06P049158

Summaries for OR2J1 Gene

Entrez Gene Summary for OR2J1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR2J1 Gene

OR2J1 (Olfactory Receptor Family 2 Subfamily J Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J2.

UniProtKB/Swiss-Prot Summary for OR2J1 Gene

Gene Wiki entry for OR2J1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2J1 Gene

Genomics for OR2J1 Gene

Genomic Locations for OR2J1 Gene

Latest Assembly
chr6:29,099,490-29,102,701
(GRCh38/hg38)
Size:
3,212 bases
Orientation:
Plus strand

Previous Assembly
chr6:29,067,267-29,070,478
(GRCh37/hg19 by Entrez Gene)
Size:
3,212 bases
Orientation:
Plus strand

chr6:29,068,386-29,069,658
(GRCh37/hg19 by Ensembl)
Size:
1,273 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_1):365,113-368,331 (+)
  • chr6(ALT_REF_LOCI_2):586,033-589,247 (+)
  • chr6(ALT_REF_LOCI_3):365,091-368,309 (+)
  • chr6(ALT_REF_LOCI_4):365,048-368,266 (+)
  • chr6(ALT_REF_LOCI_5):365,220-368,438 (+)
  • chr6(ALT_REF_LOCI_6):365,070-368,288 (+)
  • chr6(ALT_REF_LOCI_7):408,853-412,071 (+)

Genomic View for OR2J1 Gene

Genes around OR2J1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2J1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for GeneHancer (GH) Regulatory Elements for OR2J1 Gene

Proteins for OR2J1 Gene

  • Protein details for OR2J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK6-OR2J1_HUMAN
    Recommended name:
    Olfactory receptor 2J1
    Protein Accession:
    Q9GZK6
    Secondary Accessions:
    • A2AAS1
    • B0V1T2
    • Q9GZK1

    Protein attributes for OR2J1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35454 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J1 Gene

Post-translational modifications for OR2J1 Gene

  • Glycosylation at Asn6

Other Protein References for OR2J1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2J1 Gene

Domains & Families for OR2J1 Gene

Gene Families for OR2J1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2J1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2J1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 6-5 (OR2J1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZK6

UniProtKB/Swiss-Prot:

OR2J1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J1: view

Function for OR2J1 Gene

Molecular function for OR2J1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2J1 Gene

Gene Ontology (GO) - Molecular Function for OR2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2J1: view
genes like me logo Genes that share phenotypes with OR2J1: view

miRNA for OR2J1 Gene

miRTarBase miRNAs that target OR2J1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2J1 Gene

Localization for OR2J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J1 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2J1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR2J1 Gene

Pathways & Interactions for OR2J1 Gene

genes like me logo Genes that share pathways with OR2J1: view

Pathways by source for OR2J1 Gene

1 KEGG pathway for OR2J1 Gene

Interacting Proteins for OR2J1 Gene

Gene Ontology (GO) - Biological Process for OR2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J1: view

No data available for SIGNOR curated interactions for OR2J1 Gene

Drugs & Compounds for OR2J1 Gene

No Compound Related Data Available

Transcripts for OR2J1 Gene

mRNA/cDNA for OR2J1 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J1 Gene

No ASD Table

Relevant External Links for OR2J1 Gene

GeneLoc Exon Structure for
OR2J1

Expression for OR2J1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2J1 Gene

genes like me logo Genes that share expression patterns with OR2J1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2J1 Gene

Orthologs for OR2J1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR2J1 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 87 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr137 30
  • 80 (a)
OneToMany
Or2au1-ps 45 Olfr762-ps1
  • chr17:38,314,181-38,314,591
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
OneToMany
Species where no ortholog for OR2J1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2J1 Gene

ENSEMBL:
Gene Tree for OR2J1 (if available)
TreeFam:
Gene Tree for OR2J1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2J1: view image
Alliance of Genome Resources:
Additional Orthologs for OR2J1

Paralogs for OR2J1 Gene

(452) SIMAP similar genes for OR2J1 Gene using alignment to 1 proteins:

  • OR2J1_HUMAN
genes like me logo Genes that share paralogs with OR2J1: view

Variants for OR2J1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J1 Gene

OR2J1_HUMAN-Q9GZK6
A stop codon in the gene coding for this protein at position Gln-194 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2J1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs3131087 -- p.Leu14Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2J1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR2J1 Gene

Gene Damage Index Score: 19.95; 98.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2J1 Gene

Human Gene Mutation Database (HGMD)
OR2J1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2J1
Leiden Open Variation Database (LOVD)
OR2J1

No data available for Structural Variations from Database of Genomic Variants (DGV) for OR2J1 Gene

Disorders for OR2J1 Gene

Additional Disease Information for OR2J1

No disorders were found for OR2J1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2J1 Gene

Publications for OR2J1 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3
  3. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4

Products for OR2J1 Gene

Sources for OR2J1 Gene