Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR2I1P (Olfactory Receptor Family 2 Subfamily I Member 1 Pseudogene) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2Y1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J029552 | Enhancer | 0.9 | FANTOM5 ENCODE | 0.7 | +2.3 | 2341 | 0.3 | SP1 CREB1 PRDM10 RFX5 ZNF561 SP2 OSR2 ZBTB40 WT1 OVOL3 | TRIM39 HCG18 TRIM26 IFITM4P UBD LINC02829 HLA-F HLA-A OR2I1P MAS1L | |
GH06J029553 | Enhancer | 0.8 | ENCODE | 0.7 | +3.3 | 3302 | 0.2 | TEAD4 KDM1A ZNF692 ZIC2 RBFOX2 PATZ1 ZNF501 EZH2 SCRT2 CTCF | ZFP57 LINC01015 ENSG00000237669 OR2I1P UBD MAS1L | |
GH06J029558 | Promoter | 0.7 | Ensembl | 0.4 | +8.7 | 8694 | 0.6 | ZNF740 KAT8 POLR2A YY1 ZBTB11 EHMT2 GTF2A2 MLLT1 | UBD HLA-J HLA-W ENSG00000237669 LINC02829 OR2I1P MAS1L GABBR1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of human and mouse.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Or2bd2 46 Olfr1344 |
|
|
|
Or2i1 46 Olfr94 |
|
|
No disorders were found for OR2I1P Gene.