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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR2H2 (Olfactory Receptor Family 2 Subfamily H Member 2) is a Protein Coding gene. Diseases associated with OR2H2 include Acute Pulmonary Heart Disease and Acute Cor Pulmonale. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2H1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | TAS | 7665158 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0007618 | mating | TAS | 7665158 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC100615382 30 |
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OR2H2 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Olr1750 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or2h2 46 Olfr90 30 17 |
|
|
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Olfr132 31 |
|
ManyToMany | |||
Or2h2b-ps 46 Olfr753-ps1 |
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|||
Or2h2c 46 Olfr92 |
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|||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3129034 | -. - | p.Leu30Ilep.Leu30Phe | |||
rs11966382 | - | p.Val38Met | |||
rs1233387 | - | p.Ala48Val | |||
rs141430371 | - | p.Thr220Ala | |||
VAR_010227 | - | p.Leu30Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759411 | CNV | gain+loss | 17122850 |
esv3608481 | CNV | loss | 21293372 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1145096 | CNV | deletion | 24896259 |
nsv519288 | CNV | loss | 19592680 |
nsv5239 | CNV | deletion | 18451855 |
nsv970099 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute pulmonary heart disease |
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acute cor pulmonale |
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intestinal tuberculosis |
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gastrointestinal tuberculosis |
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abdominal tuberculosis |
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