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Aliases for OR2H1 Gene

Aliases for OR2H1 Gene

  • Olfactory Receptor Family 2 Subfamily H Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily H, Member 8 2 3
  • Olfactory Receptor OR6-32 3 4
  • Olfactory Receptor 2H6 3 4
  • Olfactory Receptor 2H8 3 4
  • Olfactory Receptor 6-2 3 4
  • OLFR42A-9004.14/9026.2 3 4
  • HS6M1-16 3 4
  • OR2H6 3 4
  • OR2H8 3 4
  • OR6-2 3 4
  • Olfactory Receptor, Family 2, Subfamily H, Member 1 2
  • Olfactory Receptor, Family 2, Subfamily H, Member 6 3
  • Olfactory Receptor 2H1 3
  • OLFR42A-9004-14 3
  • DJ994E9.4 3
  • 6M1-16 3

External Ids for OR2H1 Gene

Previous HGNC Symbols for OR2H1 Gene

  • OR2H6
  • OR2H8

Previous GeneCards Identifiers for OR2H1 Gene

  • GC06U990209
  • GC06M029486
  • GC06P029196
  • GC06P029534
  • GC06P029424
  • GC06Po29356

Summaries for OR2H1 Gene

Entrez Gene Summary for OR2H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2H1 Gene

OR2H1 (Olfactory Receptor Family 2 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2H2.

UniProtKB/Swiss-Prot for OR2H1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2H1 Gene

Additional gene information for OR2H1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2H1 Gene

Genomics for OR2H1 Gene

GeneHancer (GH) Regulatory Elements for OR2H1 Gene

Promoters and enhancers for OR2H1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I029457 Promoter 0.5 EPDnew 550.8 +0.0 27 0.1 GC06P029458 GC06P029490 GC06P031363 GC06P031405 GC06P031418 GC06P031455 GC06P031466 GC06P031544 GC06P031545 GC06M029455
GH06I029461 Promoter 0.5 EPDnew 550.8 +4.4 4426 0.1 GC06P029460 GC06P029462 GC06P029463 GC06P029464 GC06P029476 GC06P029477 GC06P029486 GC06P029488 GC06P029489 GC06P029491
GH06I029708 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +252.3 252255 2.6 PKNOX1 IKZF1 CREB1 CEBPB EBF1 RUNX3 PRDM1 ATF2 GC06M030353 ZDHHC20P1 HLA-F ZFP57 HLA-J IFITM4P HLA-H HCG4P5 ZNRD1ASP OR2H1
GH06I029509 Enhancer 0.5 FANTOM5 10.8 +52.2 52176 0.1 IKZF1 EBF1 RUNX3 RELA LINC01015 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 PIRC24 LOC105375009
GH06I029467 Enhancer 0.2 FANTOM5 1.9 +10.6 10566 0.3 GC06M029436 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2H1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2H1 gene promoter:

Genomic Locations for OR2H1 Gene

Genomic Locations for OR2H1 Gene
7,196 bases
Plus strand

Genomic View for OR2H1 Gene

Genes around OR2H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2H1 Gene

  • Protein details for OR2H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2H1
    Protein Accession:
    Secondary Accessions:
    • B0S7T4
    • O43629
    • O43661
    • O43662
    • Q5SUN6
    • Q9GZK9

    Protein attributes for OR2H1 Gene

    316 amino acids
    Molecular mass:
    35339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2H1 Gene

Post-translational modifications for OR2H1 Gene

No data available for DME Specific Peptides for OR2H1 Gene

Domains & Families for OR2H1 Gene

Gene Families for OR2H1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2H1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2H1: view

Function for OR2H1 Gene

Molecular function for OR2H1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily H,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2H1 Gene

Gene Ontology (GO) - Molecular Function for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2H1: view
genes like me logo Genes that share phenotypes with OR2H1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2H1 Gene

Localization for OR2H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2H1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2H1 Gene

Pathways & Interactions for OR2H1 Gene

genes like me logo Genes that share pathways with OR2H1: view

Pathways by source for OR2H1 Gene

1 KEGG pathway for OR2H1 Gene

Interacting Proteins for OR2H1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: ENSP00000366336 Q9GZK4-OR2H1_HUMAN for OR2H1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2H1: view

No data available for SIGNOR curated interactions for OR2H1 Gene

Drugs & Compounds for OR2H1 Gene

No Compound Related Data Available

Transcripts for OR2H1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2H1 Gene

No ASD Table

Relevant External Links for OR2H1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2H1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2H1 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for OR2H1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2H1 Gene

Protein tissue co-expression partners for OR2H1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OR2H1 Gene:


SOURCE GeneReport for Unigene cluster for OR2H1 Gene:

genes like me logo Genes that share expression patterns with OR2H1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2H1 Gene

Orthologs for OR2H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2H1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC462525 33
  • 98 (n)
OR2H1 34
  • 96 (a)
(Bos Taurus)
Mammalia OR2H1 33
  • 87.39 (n)
-- 34
  • 85 (a)
(Mus musculus)
Mammalia Or2h1 51 Olfr91 33 16 34
  • 85.36 (n)
Olfr90 34
  • 83 (a)
Or2h1b 51 Olfr93 34
  • 81 (a)
Olfr92 34
  • 80 (a)
(Rattus norvegicus)
Mammalia Olr1749 33
  • 85.04 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
(Canis familiaris)
Mammalia -- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
Species where no ortholog for OR2H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2H1 Gene

Gene Tree for OR2H1 (if available)
Gene Tree for OR2H1 (if available)

Paralogs for OR2H1 Gene

Paralogs for OR2H1 Gene

(434) SIMAP similar genes for OR2H1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2H1: view

Variants for OR2H1 Gene

Sequence variations from dbSNP and Humsavar for OR2H1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000056611 -- 29,460,900(+) G/A 5_prime_UTR_variant, intron_variant
rs1000325130 -- 29,455,252(+) T/C upstream_transcript_variant
rs1001199599 -- 29,461,289(+) G/A 5_prime_UTR_variant, intron_variant
rs1002229713 -- 29,455,801(+) A/C/G upstream_transcript_variant
rs1002371386 -- 29,463,864(+) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2H1 Gene

Variant ID Type Subtype PubMed ID
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv830624 CNV loss 17160897
nsv969371 CNV duplication 23825009

Variation tolerance for OR2H1 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2H1 Gene

Disorders for OR2H1 Gene

Additional Disease Information for OR2H1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR2H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2H1 Gene

Publications for OR2H1 Gene

  1. Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy JP … Gourraud PA (Human molecular genetics 2010) 3 44 58
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A … Ziegler A (The Journal of biological chemistry 2003) 3 4 58

Products for OR2H1 Gene

Sources for OR2H1 Gene

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