Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2G3 Gene

Aliases for OR2G3 Gene

  • Olfactory Receptor Family 2 Subfamily G Member 3 2 3 5
  • Olfactory Receptor OR1-33 3 4
  • Olfactory Receptor 2G3 3 4
  • Olfactory Receptor, Family 2, Subfamily G, Member 3 2
  • OR1-33 3
  • OR2G3 5

External Ids for OR2G3 Gene

Previous GeneCards Identifiers for OR2G3 Gene

  • GC01U990412
  • GC01P244078
  • GC01P245835
  • GC01P247768

Summaries for OR2G3 Gene

Entrez Gene Summary for OR2G3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2G3 Gene

OR2G3 (Olfactory Receptor Family 2 Subfamily G Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2G6.

UniProtKB/Swiss-Prot Summary for OR2G3 Gene

Gene Wiki entry for OR2G3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2G3 Gene

Genomics for OR2G3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2G3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247401 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10 -203.6 -203585 2.8 MAFK IKZF1 TCF12 CEBPB RAD21 FOS CTCF DPF2 ARNT GATAD2B HSALNG0012259 NLRP3 OR2B11 OR2C3 ZNF496 OR2G3 AHCTF1 LOC107985375 MK280269-007
GH01J247494 Enhancer 0.7 Ensembl ENCODE 10.6 -111.0 -110985 3.2 NFIC BHLHE40 SPI1 LCORL NFIB CEBPB IKZF1 OR2B11 OR2G2 OR2C3 GCSAML-AS1 OR2G3 ENSG00000235749 ENSG00000236817 ZNF496 GCSAML OR2W5P
GH01J247465 Enhancer 0.3 Ensembl 10.2 -139.7 -139685 1 ZNF512 ZNF496 OR2G3 GCSAML-AS1 OR2B11 OR2W5P GCSAML HSALNG0012262 MK280269-007
GH01J247272 Enhancer 0.3 Ensembl 9.9 -332.3 -332285 0.6 USF1 HSALNG0012247 LOC105373273 OR2G3 ZNF496 ENSG00000259865 piR-38735 VN1R5 MK280269-007
GH01J247557 Enhancer 0.2 FANTOM5 10.8 -47.8 -47814 0.3 GCSAML OR2G2 OR2C3 OR2G3 ZNF496 piR-47873
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2G3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2G3

Top Transcription factor binding sites by QIAGEN in the OR2G3 gene promoter:
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Meis-1b
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR2G3 Gene

Latest Assembly
chr1:247,605,586-247,606,515
(GRCh38/hg38)
Size:
930 bases
Orientation:
Plus strand

Previous Assembly
chr1:247,768,888-247,769,817
(GRCh37/hg19 by Entrez Gene)
Size:
930 bases
Orientation:
Plus strand

chr1:247,768,856-247,769,838
(GRCh37/hg19 by Ensembl)
Size:
983 bases
Orientation:
Plus strand

Genomic View for OR2G3 Gene

Genes around OR2G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2G3 Gene

Proteins for OR2G3 Gene

  • Protein details for OR2G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGZ4-OR2G3_HUMAN
    Recommended name:
    Olfactory receptor 2G3
    Protein Accession:
    Q8NGZ4
    Secondary Accessions:
    • B2RN64
    • Q5JQT1
    • Q6IF45

    Protein attributes for OR2G3 Gene

    Size:
    309 amino acids
    Molecular mass:
    34506 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04815.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2G3 Gene

Post-translational modifications for OR2G3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2G3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2G3 Gene

Domains & Families for OR2G3 Gene

Gene Families for OR2G3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2G3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2G3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-33 (OR2G3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGZ4

UniProtKB/Swiss-Prot:

OR2G3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2G3: view

Function for OR2G3 Gene

Molecular function for OR2G3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2G3 Gene

Gene Ontology (GO) - Molecular Function for OR2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2G3: view
genes like me logo Genes that share phenotypes with OR2G3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2G3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2G3 Gene

Localization for OR2G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2G3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2G3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2G3 Gene

Pathways & Interactions for OR2G3 Gene

genes like me logo Genes that share pathways with OR2G3: view

Pathways by source for OR2G3 Gene

Interacting Proteins for OR2G3 Gene

Gene Ontology (GO) - Biological Process for OR2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2G3: view

No data available for SIGNOR curated interactions for OR2G3 Gene

Drugs & Compounds for OR2G3 Gene

No Compound Related Data Available

Transcripts for OR2G3 Gene

mRNA/cDNA for OR2G3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2G3

Alternative Splicing Database (ASD) splice patterns (SP) for OR2G3 Gene

No ASD Table

Relevant External Links for OR2G3 Gene

GeneLoc Exon Structure for
OR2G3

Expression for OR2G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2G3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2G3

SOURCE GeneReport for Unigene cluster for OR2G3 Gene:

Hs.653227

Evidence on tissue expression from TISSUES for OR2G3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR2G3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2G3 Gene

Orthologs for OR2G3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2G3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC739672 29
  • 99.35 (n)
OR2G3 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR2G3 29 30
  • 86.3 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OR2G3 30
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 66 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr1384 30
  • 53 (a)
ManyToMany
Species where no ortholog for OR2G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2G3 Gene

ENSEMBL:
Gene Tree for OR2G3 (if available)
TreeFam:
Gene Tree for OR2G3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2G3: view image
Alliance of Genome Resources:
Additional Orthologs for OR2G3

Paralogs for OR2G3 Gene

(450) SIMAP similar genes for OR2G3 Gene using alignment to 1 proteins:

  • OR2G3_HUMAN
genes like me logo Genes that share paralogs with OR2G3: view

Variants for OR2G3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2G3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs56795889 Benign: not provided 247,606,123(+) G/A
NM_001001914.1(OR2G3):c.538G>A (p.Glu180Lys)
MISSENSE
rs61751929 Benign: not provided 247,605,646(+) C/T
NM_001001914.1(OR2G3):c.61C>T (p.Pro21Ser)
MISSENSE
rs12072304 -- p.Val258Met
rs6658792 -- p.Leu164Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2G3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2G3 Gene

Variant ID Type Subtype PubMed ID
esv2759014 CNV gain+loss 17122850
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
nsv1003572 CNV loss 25217958
nsv1004736 CNV gain 25217958
nsv1006136 CNV loss 25217958

Variation tolerance for OR2G3 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.61; 93.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2G3
Leiden Open Variation Database (LOVD)
OR2G3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2G3 Gene

Disorders for OR2G3 Gene

Additional Disease Information for OR2G3

No disorders were found for OR2G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2G3 Gene

Publications for OR2G3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR2G3 Gene

Sources for OR2G3 Gene