Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2F2 Gene

Aliases for OR2F2 Gene

  • Olfactory Receptor Family 2 Subfamily F Member 2 2 3 5
  • OR7-1 2 3 4
  • Olfactory Receptor OR7-6 3 4
  • Olfactory Receptor 2F2 3 4
  • Olfactory Receptor 7-1 3 4
  • Olfactory Receptor, Family 2, Subfamily F, Member 2 2
  • OR2F2 5

External Ids for OR2F2 Gene

Previous GeneCards Identifiers for OR2F2 Gene

  • GC07U990170
  • GC07P143025
  • GC07P143069
  • GC07P143265
  • GC07P143632
  • GC07P143937
  • GC07P143938
  • GC07P144248
  • GC07P144382
  • GC07P144511
  • GC07P144753
  • GC07P144009
  • GC07P144105
  • GC07P144985
  • GC07P145240

Summaries for OR2F2 Gene

Entrez Gene Summary for OR2F2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2F2 Gene

OR2F2 (Olfactory Receptor Family 2 Subfamily F Member 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2F1.

UniProtKB/Swiss-Prot Summary for OR2F2 Gene

Gene Wiki entry for OR2F2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2F2 Gene

Genomics for OR2F2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2F2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143933 Enhancer 0.8 Ensembl ENCODE 250.7 +0.2 239 2.9 FOXA2 MAFF ZNF316 MAFK MAFG JUND ATF4 RFX1 POLR2A HLF OR2F2 ARHGEF35 OR2F1 TCAF1 OR2A7 lnc-OR2F1-1 CAPZA1P5 lnc-TCAF1-1 OR6B1
GH07J143978 Enhancer 0.9 Ensembl ENCODE 0.3 +44.4 44350 2.2 JUND CEBPB EP300 CTBP1 TAL1 USF2 STAT5A FOXA1 TCF12 MTA2 CAPZA1P5 OR2Q1P lnc-TCAF1-1 OR2F1 OR2A25 OR2A41P LOC154761 OR6B1 OR2F2 lnc-OR2F1-1
GH07J143929 Enhancer 0.5 ENCODE 0.4 -5.3 -5291 1 JUND MCM3 BATF FOS PKNOX1 ARHGEF35 OR2A1 OR2F1 CASP2 TCAF1 LOC154761 ARHGEF35-AS1 OR2A5 OR2F2 HSALNG0061978
GH07J143957 Enhancer 0.6 Ensembl 0.4 +23.3 23335 1.4 FOXA2 RARA NR2F6 RFX1 RXRB ARID3A ZNF384 PKNOX1 RFX3 EP300 ARHGEF35 TCAF1 CAPZA1P5 lnc-TCAF1-1 OR2F2 OR6B1 lnc-OR2F1-1 OR2F1
GH07J143972 Enhancer 0.7 Ensembl ENCODE 0.3 +39.0 38950 2.3 JUND CEBPB ZNF217 ELF1 CTBP1 TAL1 TCF7L2 ELF3 OR6B1 OR2A5 CAPZA1P5 lnc-TCAF1-1 OR2F2 OR2F1 lnc-OR2F1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2F2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2F2

Top Transcription factor binding sites by QIAGEN in the OR2F2 gene promoter:
  • AP-4
  • ARP-1
  • Brachyury
  • E47
  • FOXD3
  • HEN1
  • HNF-4alpha1
  • IRF-2
  • LUN-1
  • Pax-4a

Genomic Locations for OR2F2 Gene

Latest Assembly
chr7:143,935,166-143,936,279
(GRCh38/hg38)
Size:
1,114 bases
Orientation:
Plus strand

Previous Assembly
chr7:143,632,326-143,633,279
(GRCh37/hg19 by Entrez Gene)
Size:
954 bases
Orientation:
Plus strand

chr7:143,632,259-143,633,372
(GRCh37/hg19 by Ensembl)
Size:
1,114 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr7(PATCHES):479,462-480,415 (+)

Genomic View for OR2F2 Gene

Genes around OR2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2F2 Gene

Proteins for OR2F2 Gene

  • Protein details for OR2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95006-OR2F2_HUMAN
    Recommended name:
    Olfactory receptor 2F2
    Protein Accession:
    O95006
    Secondary Accessions:
    • A4D2G0
    • Q6IFP8

    Protein attributes for OR2F2 Gene

    Size:
    317 amino acids
    Molecular mass:
    35294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2F2 Gene

Post-translational modifications for OR2F2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2F2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2F2 Gene

Domains & Families for OR2F2 Gene

Gene Families for OR2F2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2F2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2F2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 2, subfamily F, member 2 (B2RNC7_HUMAN)
  • Olfactory receptor OR7-6 (OR2F2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95006

UniProtKB/Swiss-Prot:

OR2F2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2F2: view

Function for OR2F2 Gene

Molecular function for OR2F2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily F,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2F2 Gene

Gene Ontology (GO) - Molecular Function for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2F2: view
genes like me logo Genes that share phenotypes with OR2F2: view

Animal Models for research

miRNA for OR2F2 Gene

miRTarBase miRNAs that target OR2F2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2F2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2F2 Gene

Localization for OR2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2F2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2F2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2F2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2F2 Gene

Pathways & Interactions for OR2F2 Gene

genes like me logo Genes that share pathways with OR2F2: view

Pathways by source for OR2F2 Gene

1 KEGG pathway for OR2F2 Gene

Interacting Proteins for OR2F2 Gene

Gene Ontology (GO) - Biological Process for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2F2: view

No data available for SIGNOR curated interactions for OR2F2 Gene

Drugs & Compounds for OR2F2 Gene

No Compound Related Data Available

Transcripts for OR2F2 Gene

mRNA/cDNA for OR2F2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2F2

Alternative Splicing Database (ASD) splice patterns (SP) for OR2F2 Gene

No ASD Table

Relevant External Links for OR2F2 Gene

GeneLoc Exon Structure for
OR2F2

Expression for OR2F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2F2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2F2 Gene

This gene is overexpressed in Testis (x28.0), Brain - Caudate (basal ganglia) (x6.7), Brain - Nucleus accumbens (basal ganglia) (x6.3), Cervix - Ectocervix (x6.0), and Cervix - Endocervix (x5.8).

Protein differential expression in normal tissues from HIPED for OR2F2 Gene

This gene is overexpressed in Blymphocyte (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2F2 Gene



Protein tissue co-expression partners for OR2F2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2F2

SOURCE GeneReport for Unigene cluster for OR2F2 Gene:

Hs.553596
genes like me logo Genes that share expression patterns with OR2F2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2F2 Gene

Orthologs for OR2F2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2F2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC472566 29
  • 98.21 (n)
OR2F2 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 87 (a)
ManyToMany
-- 30
  • 87 (a)
ManyToMany
-- 30
  • 86 (a)
ManyToMany
-- 30
  • 83 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 85 (a)
ManyToMany
cOR13M4 30
  • 84 (a)
ManyToMany
-- 30
  • 84 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr453 30
  • 84 (a)
ManyToMany
Olfr38 30
  • 83 (a)
ManyToMany
Or2f2 45 Olfr452 29 16 30
  • 82.86 (n)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr808 29
  • 82.33 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 79 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488194 29
  • 56 (n)
Species where no ortholog for OR2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2F2 Gene

ENSEMBL:
Gene Tree for OR2F2 (if available)
TreeFam:
Gene Tree for OR2F2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2F2: view image
Alliance of Genome Resources:
Additional Orthologs for OR2F2

Paralogs for OR2F2 Gene

(455) SIMAP similar genes for OR2F2 Gene using alignment to 2 proteins:

  • OR2F2_HUMAN
  • B2RNC7_HUMAN
genes like me logo Genes that share paralogs with OR2F2: view

Variants for OR2F2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2F2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs13229174 -- p.Thr170Ala
rs13235235 -- p.Tyr278His
rs2240359 -- p.Ala98Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2F2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2F2 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2735282 CNV deletion 23290073
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3615312 CNV gain 21293372
esv3615313 CNV gain 21293372
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1021504 CNV loss 25217958
nsv428188 CNV gain+loss 18775914
nsv469570 CNV gain+loss 16826518
nsv471645 CNV gain+loss 15918152
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv966903 CNV duplication 23825009

Variation tolerance for OR2F2 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.81; 94.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2F2
Leiden Open Variation Database (LOVD)
OR2F2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2F2 Gene

Disorders for OR2F2 Gene

Additional Disease Information for OR2F2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR2F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2F2 Gene

Publications for OR2F2 Gene

  1. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso GM … Brousseau ME (Journal of lipid research 2010) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
  5. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3

Products for OR2F2 Gene

Sources for OR2F2 Gene