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Aliases for OR2F1 Gene

Aliases for OR2F1 Gene

  • Olfactory Receptor Family 2 Subfamily F Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 2, Subfamily F, Member 1 2 3
  • Olfactory Receptor-Like Protein OLF3 3 4
  • Olfactory Receptor 2F3 3 4
  • Olfactory Receptor 2F4 3 4
  • Olfactory Receptor 2F5 3 4
  • OR2F3P 3 4
  • OR2F3 3 4
  • OR2F4 3 4
  • OR2F5 3 4
  • OLF3 3 4
  • Olfactory Receptor, Family 2, Subfamily F, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily F, Member 3 3
  • Olfactory Receptor, Family 2, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 2, Subfamily F, Member 5 3
  • Olfactory Receptor OR7-7 3
  • Olfactory Receptor 2F1 3
  • OR14-60 3
  • OR7-139 3
  • OR7-140 3
  • 7M1-2 3

External Ids for OR2F1 Gene

Previous HGNC Symbols for OR2F1 Gene

  • OR2F4
  • OR2F5
  • OR2F3
  • OR2F3P

Previous GeneCards Identifiers for OR2F1 Gene

  • GC07P141903
  • GC07P142971
  • GC07P143049
  • GC07P143050
  • GC07P143094
  • GC07P143287
  • GC07P143657
  • GC07P143959

Summaries for OR2F1 Gene

Entrez Gene Summary for OR2F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR2F1 Gene

OR2F1 (Olfactory Receptor Family 2 Subfamily F Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2F2.

UniProtKB/Swiss-Prot for OR2F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2F1 Gene

Additional gene information for OR2F1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2F1 Gene

Genomics for OR2F1 Gene

GeneHancer (GH) Regulatory Elements for OR2F1 Gene

Promoters and enhancers for OR2F1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I144018 Enhancer 1 Ensembl ENCODE 10.9 +113.0 112983 3.4 MEIS2 SOX13 JUN CEBPG BMI1 FOSL1 CTBP1 GATA3 POLR2A EGR1 ARHGEF35 OR2A5 OR2F1 LOC154761 OR6B1
GH07I143978 Enhancer 0.7 ENCODE 12 +72.3 72345 2.1 ATF1 JUN TEAD4 TAL1 TCF12 CTBP1 NCOR1 CBFA2T2 ATF7 FOSL2 LOC100422324 OR2Q1P OR2F1 OR2A25 OR2A41P LOC154761 OR2F2
GH07I143933 Enhancer 0.7 ENCODE 11.7 +28.3 28279 2.9 FOXA2 RFX1 HLF MAFG CEBPG ZFHX2 ATF4 MAFF JUND ZNF316 OR2F2 ARHGEF35 OR2F1 TCAF1 OR2A7 LOC100422324
GH07I143989 Enhancer 0.7 ENCODE 11.7 +82.3 82297 0.2 MEIS2 PKNOX1 ATF1 TEAD4 TAL1 CHAMP1 TCF12 CTBP1 GATA2 NCOR1 OR2F1 OR2A5 SLC16A1P1 OR6B1
GH07I143898 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 2.7 -4.0 -3970 9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 TCAF1 ARHGEF35 CASP2 OR2A13P OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1 LOC105375549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2F1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2F1 gene promoter:

Genomic Locations for OR2F1 Gene

Genomic Locations for OR2F1 Gene
90,187 bases
Plus strand

Genomic View for OR2F1 Gene

Genes around OR2F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2F1 Gene

Proteins for OR2F1 Gene

  • Protein details for OR2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2F1
    Protein Accession:
    Secondary Accessions:
    • A4D2G1
    • Q6IFP7
    • Q96R49
    • Q9UDX1

    Protein attributes for OR2F1 Gene

    317 amino acids
    Molecular mass:
    35350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2F1 Gene

Post-translational modifications for OR2F1 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2F1 Gene

Domains & Families for OR2F1 Gene

Gene Families for OR2F1 Gene

Protein Domains for OR2F1 Gene

Suggested Antigen Peptide Sequences for OR2F1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2F1: view

Function for OR2F1 Gene

Molecular function for OR2F1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2F1: view
genes like me logo Genes that share phenotypes with OR2F1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2F1 Gene

Localization for OR2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2F1 Gene

Pathways & Interactions for OR2F1 Gene

genes like me logo Genes that share pathways with OR2F1: view

Pathways by source for OR2F1 Gene

1 KEGG pathway for OR2F1 Gene

Interacting Proteins for OR2F1 Gene

Gene Ontology (GO) - Biological Process for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9500546
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2F1: view

No data available for SIGNOR curated interactions for OR2F1 Gene

Drugs & Compounds for OR2F1 Gene

No Compound Related Data Available

Transcripts for OR2F1 Gene

mRNA/cDNA for OR2F1 Gene

(3) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2F1 Gene

No ASD Table

Relevant External Links for OR2F1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2F1 Gene

This gene is overexpressed in Testis (x19.7).

NURSA nuclear receptor signaling pathways regulating expression of OR2F1 Gene:


SOURCE GeneReport for Unigene cluster for OR2F1 Gene:

genes like me logo Genes that share expression patterns with OR2F1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2F1 Gene

Orthologs for OR2F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2F1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC472567 33
  • 99.26 (n)
OR2F1 34
  • 98 (a)
(Bos Taurus)
Mammalia LOC613799 33
  • 87.97 (n)
-- 34
  • 87 (a)
-- 34
  • 86 (a)
-- 34
  • 86 (a)
-- 34
  • 85 (a)
(Canis familiaris)
Mammalia LOC100687207 33
  • 87.91 (n)
-- 34
  • 87 (a)
cOR13M4 34
  • 86 (a)
-- 34
  • 85 (a)
(Mus musculus)
Mammalia Or2f1b 51 Olfr38 34
  • 85 (a)
Olfr452 34
  • 85 (a)
Or2f1 51 Olfr453 33 16 34
  • 82.33 (n)
Or10ak11 51 Olfr1333
  • chr4:118,829,488-118,830,438
Or10ak14 51 Olfr1338
  • chr4:118,753,598-118,754,590
(Rattus norvegicus)
Mammalia Olr806 33
  • 82.86 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
-- 34
  • 79 (a)
-- 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485994 33
  • 54.49 (n)
Species where no ortholog for OR2F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2F1 Gene

Gene Tree for OR2F1 (if available)
Gene Tree for OR2F1 (if available)

Paralogs for OR2F1 Gene

Paralogs for OR2F1 Gene

(453) SIMAP similar genes for OR2F1 Gene using alignment to 2 proteins: Pseudogenes for OR2F1 Gene

genes like me logo Genes that share paralogs with OR2F1: view

Variants for OR2F1 Gene

Sequence variations from dbSNP and Humsavar for OR2F1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000158394 -- 143,952,195(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000162333 -- 143,923,165(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000163416 -- 143,930,971(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000226565 -- 143,971,061(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000253572 -- 143,927,129(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2F1 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2735282 CNV deletion 23290073
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3615313 CNV gain 21293372
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897
nsv970595 CNV duplication 23825009

Variation tolerance for OR2F1 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2F1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2F1 Gene

Disorders for OR2F1 Gene

Additional Disease Information for OR2F1

No disorders were found for OR2F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2F1 Gene

Publications for OR2F1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58

Products for OR2F1 Gene

Sources for OR2F1 Gene

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