Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2D3 Gene

Aliases for OR2D3 Gene

  • Olfactory Receptor Family 2 Subfamily D Member 3 2 3 5
  • Olfactory Receptor OR11-89 3 4
  • Olfactory Receptor 2D3 3 4
  • Olfactory Receptor, Family 2, Subfamily D, Member 3 2
  • OR11-89 3
  • OR2D3 5

External Ids for OR2D3 Gene

Previous GeneCards Identifiers for OR2D3 Gene

  • GC11U990567
  • GC11P006908
  • GC11P006898

Summaries for OR2D3 Gene

Entrez Gene Summary for OR2D3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D3 Gene

OR2D3 (Olfactory Receptor Family 2 Subfamily D Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2D2.

UniProtKB/Swiss-Prot Summary for OR2D3 Gene

Gene Wiki entry for OR2D3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2D3 Gene

Genomics for OR2D3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2D3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006654 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.6 -266.2 -266204 5.2 ZNF600 IKZF1 SIN3A FOXA2 ZNF521 SMAD4 NKRF RARA BCL6 HLTF DCHS1 RRP8 ENSG00000254641 ILK FHIP1B MRPL17 RPL21P94 ENSG00000254400 LOC100506258 TAF10
GH11J006742 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 -175.8 -175842 6.7 ZNF207 MYC NCOR1 IKZF1 ZNF592 POLR2A SIN3A TRIM22 TAL1 ZNF316 GVINP1 MRPL17 lnc-OR2AG2-1 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4
GH11J006863 Enhancer 0.2 FANTOM5 3.3 -57.6 -57598 0 OR10A2 OR2AG1 OR10A4 OR2AG2 OR2D3 OR2D2 OR6A2 DCHS1 ENSG00000283415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2D3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2D3

Top Transcription factor binding sites by QIAGEN in the OR2D3 gene promoter:
  • AREB6
  • Elk-1
  • En-1
  • GATA-1
  • MIF-1
  • Nkx6-1
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox9
  • TBP

Genomic Locations for OR2D3 Gene

Latest Assembly
chr11:6,920,974-6,922,043
(GRCh38/hg38)
Size:
1,070 bases
Orientation:
Plus strand

Previous Assembly
chr11:6,942,233-6,943,225
(GRCh37/hg19 by Entrez Gene)
Size:
993 bases
Orientation:
Plus strand

chr11:6,942,205-6,943,264
(GRCh37/hg19 by Ensembl)
Size:
1,060 bases
Orientation:
Plus strand

Genomic View for OR2D3 Gene

Genes around OR2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D3 Gene

Proteins for OR2D3 Gene

  • Protein details for OR2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGH3-OR2D3_HUMAN
    Recommended name:
    Olfactory receptor 2D3
    Protein Accession:
    Q8NGH3
    Secondary Accessions:
    • B2RP06
    • Q6IFG8
    • Q96R51

    Protein attributes for OR2D3 Gene

    Size:
    330 amino acids
    Molecular mass:
    37489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06044.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2D3 Gene

Post-translational modifications for OR2D3 Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2D3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2D3 Gene

Domains & Families for OR2D3 Gene

Gene Families for OR2D3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2D3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2D3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-89 (OR2D3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGH3

UniProtKB/Swiss-Prot:

OR2D3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2D3: view

Function for OR2D3 Gene

Molecular function for OR2D3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2D3 Gene

Gene Ontology (GO) - Molecular Function for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2D3: view

Phenotypes for OR2D3 Gene

genes like me logo Genes that share phenotypes with OR2D3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2D3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2D3 Gene

Localization for OR2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2D3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2D3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2D3 Gene

Pathways & Interactions for OR2D3 Gene

genes like me logo Genes that share pathways with OR2D3: view

Pathways by source for OR2D3 Gene

Interacting Proteins for OR2D3 Gene

Gene Ontology (GO) - Biological Process for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2D3: view

No data available for SIGNOR curated interactions for OR2D3 Gene

Drugs & Compounds for OR2D3 Gene

No Compound Related Data Available

Transcripts for OR2D3 Gene

mRNA/cDNA for OR2D3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2D3

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D3 Gene

No ASD Table

Relevant External Links for OR2D3 Gene

GeneLoc Exon Structure for
OR2D3

Expression for OR2D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2D3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2D3

SOURCE GeneReport for Unigene cluster for OR2D3 Gene:

Hs.446766
genes like me logo Genes that share expression patterns with OR2D3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2D3 Gene

Orthologs for OR2D3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2D3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466421 29
  • 98.79 (n)
OR2D3 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR10F05 29 30
  • 87.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR2D3 29 30
  • 86.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr234 29
  • 81.95 (n)
Mouse
(Mus musculus)
Mammalia Or2d36 45 Olfr716 29 16 30
  • 80.36 (n)
OneToOne
Or10ak10-ps 45 Olfr1332-ps1
  • chr4:118,854,104-118,855,009
Or10ak13 45 Olfr1337
  • chr4:118,781,639-118,782,748
Or10ak9 45 Olfr1331
  • chr4:118,868,783-118,869,733
Or13n4 45 Olfr702
  • chr7:106,823,571-106,824,524
Or13p7 45 Olfr1330
  • chr4:118,893,037-118,894,029
Or2d3 45 Olfr707
  • chr7:106,891,187-106,892,191
Or2d3b 45 Olfr1532
  • chr7:106,914,170-106,915,120
Or2d3c 45 Olfr709
  • chr7:106,926,537-106,927,562
Or2d4 45 Olfr710
  • chr7:106,944,070-106,944,999
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 52 (a)
ManyToMany
-- 30
  • 51 (a)
ManyToMany
-- 30
  • 50 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
Species where no ortholog for OR2D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2D3 Gene

ENSEMBL:
Gene Tree for OR2D3 (if available)
TreeFam:
Gene Tree for OR2D3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2D3: view image
Alliance of Genome Resources:
Additional Orthologs for OR2D3

Paralogs for OR2D3 Gene

(457) SIMAP similar genes for OR2D3 Gene using alignment to 1 proteins:

  • OR2D3_HUMAN
genes like me logo Genes that share paralogs with OR2D3: view

Variants for OR2D3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2D3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10839658 -- p.Leu82Ile
rs10839659 -- p.Trp165Ser
rs12806437 -- p.Arg155Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2D3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2D3 Gene

Variant ID Type Subtype PubMed ID
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv1046864 CNV loss 25217958
nsv832061 CNV loss 17160897

Variation tolerance for OR2D3 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.85; 98.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2D3
Leiden Open Variation Database (LOVD)
OR2D3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2D3 Gene

Disorders for OR2D3 Gene

Additional Disease Information for OR2D3

No disorders were found for OR2D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2D3 Gene

Publications for OR2D3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR2D3 Gene

Sources for OR2D3 Gene