Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2D3 Gene

Aliases for OR2D3 Gene

  • Olfactory Receptor Family 2 Subfamily D Member 3 2 3 5
  • Olfactory Receptor OR11-89 3 4
  • Olfactory Receptor, Family 2, Subfamily D, Member 3 2
  • Olfactory Receptor 2D3 3
  • OR11-89 3

External Ids for OR2D3 Gene

Previous GeneCards Identifiers for OR2D3 Gene

  • GC11U990567
  • GC11P006908
  • GC11P006898

Summaries for OR2D3 Gene

Entrez Gene Summary for OR2D3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D3 Gene

OR2D3 (Olfactory Receptor Family 2 Subfamily D Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2D2.

UniProtKB/Swiss-Prot for OR2D3 Gene

  • Odorant receptor.

Gene Wiki entry for OR2D3 Gene

Additional gene information for OR2D3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2D3 Gene

Genomics for OR2D3 Gene

GeneHancer (GH) Regulatory Elements for OR2D3 Gene

Promoters and enhancers for OR2D3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006742 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 -175.7 -175742 6.5 HDAC1 PKNOX1 SMAD1 RB1 NFRKB YBX1 BATF KLF5 TCF12 ZNF766 GVINP1 MRPL17 OR2AG2 ILK RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1
GH11J006654 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 1.6 -265.2 -265215 3 HDAC1 FOXA2 MLX SIN3A ZNF48 RARA ZNF366 EGR2 HMG20B SP5 DCHS1 RRP8 FAM160A2 ENSG00000254641 LOC100506258 LOC644169 ILK APBB1 OR2D2 TRIM3
GH11J006863 Enhancer 0.2 FANTOM5 3.3 -57.6 -57598 0 OR10A2 OR2AG1 OR10A4 OR2AG2 OR2D3 OR2D2 OR6A2 DCHS1 ENSG00000283415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2D3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2D3 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • GATA-1
  • TBP
  • AREB6
  • MIF-1
  • Elk-1
  • En-1
  • Nkx6-1
  • Sox9

Genomic Locations for OR2D3 Gene

Genomic Locations for OR2D3 Gene
1,070 bases
Plus strand
1,060 bases
Plus strand

Genomic View for OR2D3 Gene

Genes around OR2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D3 Gene

Proteins for OR2D3 Gene

  • Protein details for OR2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2D3
    Protein Accession:
    Secondary Accessions:
    • B2RP06
    • Q6IFG8
    • Q96R51

    Protein attributes for OR2D3 Gene

    330 amino acids
    Molecular mass:
    37489 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06044.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2D3 Gene

Post-translational modifications for OR2D3 Gene

  • Glycosylation at isoforms=21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2D3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2D3 Gene

Domains & Families for OR2D3 Gene

Gene Families for OR2D3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2D3 Gene

Suggested Antigen Peptide Sequences for OR2D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2D3: view

Function for OR2D3 Gene

Molecular function for OR2D3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2D3: view

Phenotypes for OR2D3 Gene

genes like me logo Genes that share phenotypes with OR2D3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2D3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2D3 Gene

Localization for OR2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2D3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2D3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2D3 Gene

Pathways & Interactions for OR2D3 Gene

genes like me logo Genes that share pathways with OR2D3: view

Pathways by source for OR2D3 Gene

Interacting Proteins for OR2D3 Gene

Gene Ontology (GO) - Biological Process for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2D3: view

No data available for SIGNOR curated interactions for OR2D3 Gene

Drugs & Compounds for OR2D3 Gene

No Compound Related Data Available

Transcripts for OR2D3 Gene

mRNA/cDNA for OR2D3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2D3 Gene

Olfactory receptor, family 2, subfamily D, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2D3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D3 Gene

No ASD Table

Relevant External Links for OR2D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2D3 Gene:


SOURCE GeneReport for Unigene cluster for OR2D3 Gene:

genes like me logo Genes that share expression patterns with OR2D3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2D3 Gene

Orthologs for OR2D3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466421 33
  • 98.79 (n)
OR2D3 34
  • 98 (a)
(Canis familiaris)
Mammalia OR10F05 34 33
  • 87.69 (n)
(Bos Taurus)
Mammalia OR2D3 34 33
  • 86.73 (n)
(Rattus norvegicus)
Mammalia Olr234 33
  • 81.95 (n)
(Mus musculus)
Mammalia Or2d36 51 Olfr716 16 34 33
  • 80.36 (n)
Or10ak10-ps 51 Olfr1332-ps1
  • chr4:118,854,104-118,855,009
Or10ak13 51 Olfr1337
  • chr4:118,781,639-118,782,748
Or10ak9 51 Olfr1331
  • chr4:118,868,783-118,869,733
Or13n4 51 Olfr702
  • chr7:106,823,571-106,824,524
Or13p7 51 Olfr1330
  • chr4:118,893,037-118,894,029
Or2d3 51 Olfr707
  • chr7:106,891,187-106,892,191
Or2d3b 51 Olfr1532
  • chr7:106,914,170-106,915,120
Or2d3c 51 Olfr709
  • chr7:106,926,537-106,927,562
Or2d4 51 Olfr710
  • chr7:106,944,070-106,944,999
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 51 (a)
-- 34
  • 50 (a)
-- 34
  • 46 (a)
Species where no ortholog for OR2D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2D3 Gene

Gene Tree for OR2D3 (if available)
Gene Tree for OR2D3 (if available)
Evolutionary constrained regions (ECRs) for OR2D3: view image

Paralogs for OR2D3 Gene

Paralogs for OR2D3 Gene

(457) SIMAP similar genes for OR2D3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2D3: view

Variants for OR2D3 Gene

Sequence variations from dbSNP and Humsavar for OR2D3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001026029 -- 6,919,389(+) C/T upstream_transcript_variant
rs1001547847 -- 6,922,364(+) C/T downstream_transcript_variant
rs1001579078 -- 6,922,020(+) T/A/C/G downstream_transcript_variant
rs1003162946 -- 6,919,451(+) T/C upstream_transcript_variant
rs1005033125 -- 6,922,421(+) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2D3 Gene

Variant ID Type Subtype PubMed ID
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv1046864 CNV loss 25217958
nsv832061 CNV loss 17160897

Variation tolerance for OR2D3 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.85; 98.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2D3 Gene

Disorders for OR2D3 Gene

Additional Disease Information for OR2D3

No disorders were found for OR2D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2D3 Gene

Publications for OR2D3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2D3 Gene

Sources for OR2D3 Gene

Loading form....