Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2D2 Gene

Aliases for OR2D2 Gene

  • Olfactory Receptor Family 2 Subfamily D Member 2 2 3 5
  • OR11-610 2 3 4
  • Olfactory Receptor OR11-88 3 4
  • Olfactory Receptor 11-610 3 4
  • Olfactory Receptor 2D2 3 4
  • Olfactory Receptor 2D1 3 4
  • OR2D1 3 4
  • Hg27 2 3
  • HB2 3 4
  • Olfactory Receptor, Family 2, Subfamily D, Member 2 2
  • Olfactory Receptor, Family 2, Subfamily D, Member 1 3
  • OR2D2 5

External Ids for OR2D2 Gene

Previous HGNC Symbols for OR2D2 Gene

  • OR2D1

Previous GeneCards Identifiers for OR2D2 Gene

  • GC11U990178
  • GC11M007374
  • GC11M006874
  • GC11M006877

Summaries for OR2D2 Gene

Entrez Gene Summary for OR2D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D2 Gene

OR2D2 (Olfactory Receptor Family 2 Subfamily D Member 2) is a Protein Coding gene. Diseases associated with OR2D2 include Osteogenesis Imperfecta, Type I and Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2D3.

UniProtKB/Swiss-Prot Summary for OR2D2 Gene

Gene Wiki entry for OR2D2 Gene

Additional gene information for OR2D2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2D2 Gene

Genomics for OR2D2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006654 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 2.5 +237.8 237829 5.2 ZNF512 SOX13 IKZF1 KDM1A MTA2 PRDM1 POLR2A RXRB NR2C1 EZH2 DCHS1 RRP8 ENSG00000254641 ILK FAM160A2 MRPL17 RPL21P94 ENSG00000254400 ENSG00000251364 TAF10
GH11J006742 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 +147.5 147467 6.7 LEF1 IKZF1 POLR2A PKNOX1 SMAD5 IKZF2 RCOR1 RELA TRIM22 DPF2 GVINP1 MRPL17 lnc-OR2AG2-1 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4
GH11J006847 Enhancer 0.2 Ensembl 10.5 +44.4 44398 0.8 OR2D2 OR10A5 piR-48209-088 OR10A2 ENSG00000283415
GH11J006863 Enhancer 0.2 FANTOM5 2.2 +29.2 29223 0 OR10A2 OR2AG1 OR10A4 OR2AG2 OR2D3 OR2D2 OR6A2 DCHS1 ENSG00000283415
GH11J006501 Enhancer 0.2 FANTOM5 1.6 +390.5 390476 0.4 piR-48759-037 TIMM10B ARFIP2 APBB1 ILK RRP8 SMPD1 OR2D2 DNHD1 ENSG00000283977
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2D2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2D2

Top Transcription factor binding sites by QIAGEN in the OR2D2 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • En-1
  • GATA-1
  • GATA-2
  • GATA-3
  • Nkx6-1

Genomic Locations for OR2D2 Gene

Genomic Locations for OR2D2 Gene
chr11:6,891,490-6,892,599
(GRCh38/hg38)
Size:
1,110 bases
Orientation:
Minus strand
chr11:6,912,721-6,913,830
(GRCh37/hg19)
Size:
1,110 bases
Orientation:
Minus strand

Genomic View for OR2D2 Gene

Genes around OR2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D2 Gene

Proteins for OR2D2 Gene

  • Protein details for OR2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H210-OR2D2_HUMAN
    Recommended name:
    Olfactory receptor 2D2
    Protein Accession:
    Q9H210
    Secondary Accessions:
    • B9EIL5
    • O95224
    • Q6IF28
    • Q8NGH4
    • Q96R52

    Protein attributes for OR2D2 Gene

    Size:
    308 amino acids
    Molecular mass:
    34172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2D2 Gene

Post-translational modifications for OR2D2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2D2 Gene

Domains & Families for OR2D2 Gene

Gene Families for OR2D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2D2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR2D2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-88 (OR2D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H210

UniProtKB/Swiss-Prot:

OR2D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2D2: view

Function for OR2D2 Gene

Molecular function for OR2D2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily D,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2D2 Gene

Gene Ontology (GO) - Molecular Function for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view
genes like me logo Genes that share phenotypes with OR2D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2D2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2D2 Gene

Localization for OR2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2D2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2D2 Gene

Pathways & Interactions for OR2D2 Gene

genes like me logo Genes that share pathways with OR2D2: view

Pathways by source for OR2D2 Gene

1 KEGG pathway for OR2D2 Gene

Interacting Proteins for OR2D2 Gene

Gene Ontology (GO) - Biological Process for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 9787077
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2D2: view

No data available for SIGNOR curated interactions for OR2D2 Gene

Drugs & Compounds for OR2D2 Gene

No Compound Related Data Available

Transcripts for OR2D2 Gene

mRNA/cDNA for OR2D2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2D2

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D2 Gene

No ASD Table

Relevant External Links for OR2D2 Gene

GeneLoc Exon Structure for
OR2D2

Expression for OR2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2D2 Gene

This gene is overexpressed in Testis (x7.2) and Brain - Putamen (basal ganglia) (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2D2

SOURCE GeneReport for Unigene cluster for OR2D2 Gene:

Hs.690210
genes like me logo Genes that share expression patterns with OR2D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2D2 Gene

Orthologs for OR2D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2D2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR2D2 30 31
  • 86.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 85 (a)
OneToMany
LOC100682782 30
  • 84.92 (n)
-- 31
  • 84 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm10081 31
  • 83 (a)
OneToMany
Or2d2 46 Olfr715 30 17 31
  • 82.95 (n)
OneToMany
Olfr715b 17
Or10ak7 46 Olfr1328
  • chr4:118,933,902-118,934,894
Or10ak8 46 Olfr1329
  • chr4:118,916,527-118,917,519
Or13p9-ps 46 Olfr1343-ps1
  • chr4:118,672,624-118,673,522
Rat
(Rattus norvegicus)
Mammalia Olr233 30
  • 81.98 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
-- 31
  • 68 (a)
OneToMany
-- 31
  • 68 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493400 30
  • 53.91 (n)
Str.13262 30
Species where no ortholog for OR2D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2D2 Gene

ENSEMBL:
Gene Tree for OR2D2 (if available)
TreeFam:
Gene Tree for OR2D2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2D2: view image

Paralogs for OR2D2 Gene

(450) SIMAP similar genes for OR2D2 Gene using alignment to 1 proteins:

  • OR2D2_HUMAN
genes like me logo Genes that share paralogs with OR2D2: view

Variants for OR2D2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2D2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1965207 - p.Ile163Met
rs1965208 - p.Ile163Thr
rs1965209 - p.Ser148Pro
rs2741804 - p.Met202Thr
rs57896484 - p.His84Tyr

Additional dbSNP identifiers (rs#s) for OR2D2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2D2 Gene

Variant ID Type Subtype PubMed ID
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv832061 CNV loss 17160897

Variation tolerance for OR2D2 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.50; 94.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2D2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2D2 Gene

Disorders for OR2D2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR2D2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search OR2D2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OR2D2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2D2 Gene

Publications for OR2D2 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR2D2 Gene

Sources for OR2D2 Gene