Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2C1 Gene

Aliases for OR2C1 Gene

  • Olfactory Receptor Family 2 Subfamily C Member 1 2 3 5
  • OLFmf3 2 3 4
  • Olfactory Receptor OR16-1 3 4
  • Olfactory Receptor OR16-2 3 4
  • Olfactory Receptor 2C1 3 4
  • Olfactory Receptor 2C2 3 4
  • OR2C2P 3 4
  • Olfactory Receptor, Family 2, Subfamily C, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily C, Member 1 2
  • OR2C1 5

External Ids for OR2C1 Gene

Previous HGNC Symbols for OR2C1 Gene

  • OR2C2P

Previous GeneCards Identifiers for OR2C1 Gene

  • GC16P003435
  • GC16P003406
  • GC16P003345
  • GC16P003405
  • GC16P003322
  • GC16P003778
  • GC16P003855
  • GC16P003905
  • GC16P004080
  • GC16P003356
  • GC16P003380
  • GC16P003416
  • GC16P003462
  • GC16P003489
  • GC16P003575
  • GC16P003622
  • GC16P004268
  • GC16P004510

Summaries for OR2C1 Gene

Entrez Gene Summary for OR2C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2C1 Gene

OR2C1 (Olfactory Receptor Family 2 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2H1.

UniProtKB/Swiss-Prot Summary for OR2C1 Gene

Gene Wiki entry for OR2C1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2C1 Gene

Genomics for OR2C1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2C1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2C1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2C1

Top Transcription factor binding sites by QIAGEN in the OR2C1 gene promoter:
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • SRF
  • SRF (504 AA)

Genomic Locations for OR2C1 Gene

Latest Assembly
chr16:3,355,889-3,357,306
(GRCh38/hg38)
Size:
1,418 bases
Orientation:
Plus strand

Previous Assembly
chr16:3,405,889-3,407,306
(GRCh37/hg19 by Entrez Gene)
Size:
1,418 bases
Orientation:
Plus strand

chr16:3,405,889-3,406,924
(GRCh37/hg19 by Ensembl)
Size:
1,036 bases
Orientation:
Plus strand

Genomic View for OR2C1 Gene

Genes around OR2C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2C1 Gene

Proteins for OR2C1 Gene

  • Protein details for OR2C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95371-OR2C1_HUMAN
    Recommended name:
    Olfactory receptor 2C1
    Protein Accession:
    O95371
    Secondary Accessions:
    • A0AVA4
    • Q6IF34
    • Q6IF55

    Protein attributes for OR2C1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2C1 Gene

Post-translational modifications for OR2C1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2C1 Gene

Domains & Families for OR2C1 Gene

Gene Families for OR2C1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2C1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2C1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR16-2 (OR2C1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95371

UniProtKB/Swiss-Prot:

OR2C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2C1: view

Function for OR2C1 Gene

Molecular function for OR2C1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2C1 Gene

Gene Ontology (GO) - Molecular Function for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity TAS,IEA --
GO:0005549 odorant binding IEA --
genes like me logo Genes that share ontologies with OR2C1: view
genes like me logo Genes that share phenotypes with OR2C1: view

Animal Models for OR2C1 Gene

MGI Knock Outs for OR2C1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2C1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR2C1 Gene

Localization for OR2C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2C1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005938 cell cortex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2C1 Gene

Pathways & Interactions for OR2C1 Gene

genes like me logo Genes that share pathways with OR2C1: view

Pathways by source for OR2C1 Gene

1 KEGG pathway for OR2C1 Gene

Interacting Proteins for OR2C1 Gene

Gene Ontology (GO) - Biological Process for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IEA --
genes like me logo Genes that share ontologies with OR2C1: view

No data available for SIGNOR curated interactions for OR2C1 Gene

Drugs & Compounds for OR2C1 Gene

No Compound Related Data Available

Transcripts for OR2C1 Gene

mRNA/cDNA for OR2C1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2C1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2C1 Gene

No ASD Table

Relevant External Links for OR2C1 Gene

GeneLoc Exon Structure for
OR2C1

Expression for OR2C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2C1 Gene

Protein differential expression in normal tissues from HIPED for OR2C1 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2C1 Gene



Protein tissue co-expression partners for OR2C1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2C1

SOURCE GeneReport for Unigene cluster for OR2C1 Gene:

Hs.258574

Evidence on tissue expression from TISSUES for OR2C1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR2C1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2C1 Gene

Orthologs for OR2C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2C1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR2C1 30
  • 87 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR2C1 30
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 84 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr1356 29
  • 81.92 (n)
Mouse
(Mus musculus)
Mammalia Or2c1 45 Olfr15 29 16 30
  • 81.77 (n)
OneToOne
Or2aa1 45 Olfr223
  • chr11:59,589,131-59,590,087
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia OR2C1 30
  • 54 (a)
OneToOne
Species where no ortholog for OR2C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2C1 Gene

ENSEMBL:
Gene Tree for OR2C1 (if available)
TreeFam:
Gene Tree for OR2C1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2C1: view image
Alliance of Genome Resources:
Additional Orthologs for OR2C1

Paralogs for OR2C1 Gene

(457) SIMAP similar genes for OR2C1 Gene using alignment to 1 proteins:

  • OR2C1_HUMAN

Pseudogenes.org Pseudogenes for OR2C1 Gene

genes like me logo Genes that share paralogs with OR2C1: view

Variants for OR2C1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2C1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs11648783 -- p.Arg229His
rs1218762 -- p.Gly16Ser
rs1218763 -- p.Cys149Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2C1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2C1 Gene

Variant ID Type Subtype PubMed ID
dgv2694n100 CNV gain 25217958
dgv2695n100 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1714 CNV insertion 18451855

Variation tolerance for OR2C1 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.75; 91.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2C1 Gene

Human Gene Mutation Database (HGMD)
OR2C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2C1
Leiden Open Variation Database (LOVD)
OR2C1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2C1 Gene

Disorders for OR2C1 Gene

Additional Disease Information for OR2C1

No disorders were found for OR2C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2C1 Gene

Publications for OR2C1 Gene

  1. Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PMID: 9847080) Centola M … Kastner DL (Genome research 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4

Products for OR2C1 Gene

Sources for OR2C1 Gene