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Aliases for OR2B6 Gene

Aliases for OR2B6 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 6 2 3 5
  • Olfactory Receptor OR6-4 3 4
  • Olfactory Receptor 5-40 3 4
  • Olfactory Receptor 6-31 3 4
  • Olfactory Receptor 2B1 3 4
  • Olfactory Receptor 2B5 3 4
  • Hs6M1-32 3 4
  • OR6-31 3 4
  • OR2B1P 3 4
  • OR2B6P 3 4
  • OR5-40 3 4
  • OR2B1 3 4
  • OR2B5 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 6 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 6 2
  • Olfactory Receptor, Family 2, Subfamily B, Member 5 3
  • Olfactory Receptor 2B6 3
  • DJ408B20.2 3
  • OR5-41 3

External Ids for OR2B6 Gene

Previous HGNC Symbols for OR2B6 Gene

  • OR2B6P
  • OR2B1
  • OR2B1P
  • OR2B5

Previous GeneCards Identifiers for OR2B6 Gene

  • GC06U990191
  • GC06P028033
  • GC06P028034
  • GC06P028035

Summaries for OR2B6 Gene

Entrez Gene Summary for OR2B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B6 Gene

OR2B6 (Olfactory Receptor Family 2 Subfamily B Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B2.

UniProtKB/Swiss-Prot for OR2B6 Gene

  • Odorant receptor.

Gene Wiki entry for OR2B6 Gene

Additional gene information for OR2B6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2B6 Gene

Genomics for OR2B6 Gene

GeneHancer (GH) Regulatory Elements for OR2B6 Gene

Promoters and enhancers for OR2B6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I027957 Promoter 0.7 EPDnew 550.8 -0.1 -79 0.1 SRF PRDM1 OR2B6 OR2W6P
GH06I027667 Enhancer 1.4 FANTOM5 Ensembl ENCODE 3 -288.4 -288440 2.8 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF766 ZNF213 E2F8 FOS KLF13 GC06P027670 TRI-AAT8-1 TRR-ACG2-4 ZSCAN12 ZKSCAN8 ZSCAN23 ZSCAN9 ZKSCAN3 ZKSCAN4 ZSCAN26
GH06I027776 Enhancer 1.2 FANTOM5 ENCODE 2.5 -179.6 -179598 1.7 ARNT YY1 GTF3C2 ZNF766 E2F8 ARID2 RUNX3 NCOA1 ZNF592 MEF2D GC06P027803 PIR58221 TRX-CAT2-1 ZKSCAN8 ZSCAN12 ZKSCAN3 ZNF603P ZSCAN23 ZSCAN9 HIST1H4PS1
GH06I028131 Enhancer 0.5 FANTOM5 dbSUPER 1.6 +174.5 174533 0.1 ZKSCAN3 ZSCAN31 ZNF165 ZSCAN16 ZSCAN26 OR2B2 OR2B6 ZKSCAN8 ZSCAN16-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2B6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2B6 gene promoter:

Genomic Locations for OR2B6 Gene

Genomic Locations for OR2B6 Gene
942 bases
Plus strand

Genomic View for OR2B6 Gene

Genes around OR2B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2B6 Gene

Proteins for OR2B6 Gene

  • Protein details for OR2B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2B6
    Protein Accession:
    Secondary Accessions:
    • O43883
    • Q6IF89
    • Q9H5B0

    Protein attributes for OR2B6 Gene

    313 amino acids
    Molecular mass:
    35414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B6 Gene

Post-translational modifications for OR2B6 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B6 Gene

Domains & Families for OR2B6 Gene

Gene Families for OR2B6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2B6 Gene

Suggested Antigen Peptide Sequences for OR2B6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B6: view

Function for OR2B6 Gene

Molecular function for OR2B6 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily B,member 6,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2B6: view

Phenotypes for OR2B6 Gene

genes like me logo Genes that share phenotypes with OR2B6: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B6 Gene

Localization for OR2B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2B6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2B6 Gene

Pathways & Interactions for OR2B6 Gene

genes like me logo Genes that share pathways with OR2B6: view

Pathways by source for OR2B6 Gene

1 KEGG pathway for OR2B6 Gene

Interacting Proteins for OR2B6 Gene

Gene Ontology (GO) - Biological Process for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B6: view

No data available for SIGNOR curated interactions for OR2B6 Gene

Drugs & Compounds for OR2B6 Gene

No Compound Related Data Available

Transcripts for OR2B6 Gene

mRNA/cDNA for OR2B6 Gene

(1) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B6 Gene

No ASD Table

Relevant External Links for OR2B6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2B6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2B6 Gene

mRNA differential expression in normal tissues according to GTEx for OR2B6 Gene

This gene is overexpressed in Whole Blood (x12.5).

Protein differential expression in normal tissues from HIPED for OR2B6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2B6 Gene

Protein tissue co-expression partners for OR2B6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2B6 Gene:


SOURCE GeneReport for Unigene cluster for OR2B6 Gene:

genes like me logo Genes that share expression patterns with OR2B6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2B6 Gene

Orthologs for OR2B6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2B6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC471910 33
  • 98.83 (n)
OR2B6 34
  • 97 (a)
(Bos Taurus)
Mammalia OR2B6 33 34
  • 86.51 (n)
(Canis familiaris)
Mammalia OR2B6 34
  • 82 (a)
(Mus musculus)
Mammalia Or2b6 51 Olfr11 33 16 34
  • 81.68 (n)
Or2ab1 51 Olfr324
  • chr11:58,597,392-58,598,390
Or2y3 51 Olfr131
  • chr17:38,082,035-38,082,976
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
-- 34
  • 66 (a)
-- 34
  • 48 (a)
-- 34
  • 45 (a)
-- 34
  • 41 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
Species where no ortholog for OR2B6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2B6 Gene

Gene Tree for OR2B6 (if available)
Gene Tree for OR2B6 (if available)

Paralogs for OR2B6 Gene

Paralogs for OR2B6 Gene

(448) SIMAP similar genes for OR2B6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2B6: view

Variants for OR2B6 Gene

Sequence variations from dbSNP and Humsavar for OR2B6 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001246256 -- 27,958,290(+) T/A downstream_transcript_variant
rs1001416608 -- 27,956,086(+) C/T upstream_transcript_variant
rs1001491243 -- 27,955,655(+) C/A upstream_transcript_variant
rs1002700917 -- 27,957,154(+) A/G upstream_transcript_variant
rs1002916700 -- 27,956,900(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2B6 Gene

Variant ID Type Subtype PubMed ID
esv3576109 CNV gain 25503493
nsv601208 CNV loss 21841781
nsv830619 CNV loss 17160897

Variation tolerance for OR2B6 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2B6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B6 Gene

Disorders for OR2B6 Gene

Additional Disease Information for OR2B6

No disorders were found for OR2B6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2B6 Gene

Publications for OR2B6 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR2B6 Gene

Sources for OR2B6 Gene

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