OR2B6 Gene (Protein Coding)

Olfactory Receptor Family 2 Subfamily B Member 6

GC06P051809
GIFtS:
36
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2B6 Gene

Aliases for OR2B6 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 6 2 3 5
  • OR5-40 2 3 4
  • OR6-31 2 3 4
  • Olfactory Receptor OR6-4 3 4
  • Olfactory Receptor 5-40 3 4
  • Olfactory Receptor 6-31 3 4
  • Olfactory Receptor 2B6 3 4
  • Olfactory Receptor 2B1 3 4
  • Olfactory Receptor 2B5 3 4
  • DJ408B20.2 2 3
  • Hs6M1-32 3 4
  • OR2B1P 3 4
  • OR2B6P 3 4
  • OR5-41 2 3
  • OR2B1 3 4
  • OR2B5 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 6 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 6 2
  • Olfactory Receptor, Family 2, Subfamily B, Member 5 3
  • OR2B6 5

External Ids for OR2B6 Gene

Previous HGNC Symbols for OR2B6 Gene

  • OR2B6P
  • OR2B1
  • OR2B1P
  • OR2B5

Previous GeneCards Identifiers for OR2B6 Gene

  • GC06U990191
  • GC06P028033
  • GC06P028034
  • GC06P028035
  • GC06P027925
  • GC06P027991
  • GC06P028353
  • GC06P028816
  • GC06P029423

Summaries for OR2B6 Gene

Entrez Gene Summary for OR2B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B6 Gene

OR2B6 (Olfactory Receptor Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with OR2B6 include Hypertrophy Of Breast. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B2.

UniProtKB/Swiss-Prot Summary for OR2B6 Gene

Gene Wiki entry for OR2B6 Gene

Additional gene information for OR2B6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2B6 Gene

Genomics for OR2B6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR2B6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J027669 Enhancer 1.2 FANTOM5 ENCODE 3 -287.9 -287897 1.6 BCLAF1 MYC IKZF1 SSRP1 ZNF580 ZNF592 ZMYM3 ZNF10 BRCA1 NFIC HSALNG0048895 TRI-AAT8-1 TRR-ACG2-4 piR-42844-002 piR-33415-006 lnc-HIST1H2BL-1 ZSCAN12 ZKSCAN3 ZSCAN26 ZKSCAN4
GH06J027776 Enhancer 1.1 FANTOM5 ENCODE 2.5 -179.6 -179598 1.7 NCOR1 IKZF1 ZNF592 NFIC TARDBP HES1 TBP MNT ARNT IRF2 TRX-CAT2-1 piR-30961-007 piR-33437-008 ZKSCAN3 ZKSCAN8 ZNF603P ZSCAN9 H4C10P H2AC13 H2BC13
GH06J028131 Enhancer 0.4 FANTOM5 dbSUPER 1.6 +174.5 174533 0.1 ZKSCAN3 ZSCAN31 ZNF165 ZSCAN16 ZSCAN26 OR2B2 OR2B6 ENSG00000261839 ZKSCAN8 ZSCAN16-AS1
GH06J028003 Enhancer 0.6 Ensembl 0.3 +47.7 47660 3 ATF2 FOXA2 YY1 ETV1 ZBTB21 MEIS2 ZMYM3 ZNF629 ZNF692 DACH1 piR-35002-054 ZNF603P ZNF165 OR2B8P piR-46501-085 OR2B6 OR1F12
GH06J027966 Enhancer 0.3 Ensembl 0.4 +9.8 9760 0.8 ZBTB33 RPLP2P1 ZNF165 OR2B6 OR2W4P OR1F12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2B6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2B6

Top Transcription factor binding sites by QIAGEN in the OR2B6 gene promoter:
  • AML1a
  • C/EBPalpha
  • C/EBPbeta
  • CHOP-10
  • CP2
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1
  • SEF-1 (1)

Genomic Locations for OR2B6 Gene

Latest Assembly
chr6:27,957,241-27,958,182
(GRCh38/hg38)
Size:
942 bases
Orientation:
Plus strand

Previous Assembly
chr6:27,925,019-27,925,960
(GRCh37/hg19 by Entrez Gene)
Size:
942 bases
Orientation:
Plus strand

chr6:27,925,019-27,925,960
(GRCh37/hg19 by Ensembl)
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR2B6 Gene

Genes around OR2B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR2B6 Gene

Proteins for OR2B6 Gene

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  • Protein details for OR2B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58173-OR2B6_HUMAN
    Recommended name:
    Olfactory receptor 2B6
    Protein Accession:
    P58173
    Secondary Accessions:
    • O43883
    • Q6IF89
    • Q9H5B0

    Protein attributes for OR2B6 Gene

    Size:
    313 amino acids
    Molecular mass:
    35414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B6 Gene

Protein Expression for OR2B6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR2B6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B6 Gene

Domains & Families for OR2B6 Gene

Gene Families for OR2B6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2B6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2B6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR6-4 (OR2B6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P58173

UniProtKB/Swiss-Prot:

OR2B6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B6: view

Function for OR2B6 Gene

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  6. Cell Lines for research

Molecular function for OR2B6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily B,member 6,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2B6 Gene

Gene Ontology (GO) - Molecular Function for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2B6: view
genes like me logo Genes that share phenotypes with OR2B6: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2B6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B6 Gene

Localization for OR2B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2B6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2B6 Gene

Pathways & Interactions for OR2B6 Gene

genes like me logo Genes that share pathways with OR2B6: view

Pathways by source for OR2B6 Gene

2 BioSystems pathways for OR2B6 Gene
1 KEGG pathway for OR2B6 Gene

Interacting Proteins for OR2B6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000244623 P58173-OR2B6_HUMAN for OR2B6 Gene via STRING IID

GPS-Prot Interaction Network for OR2B6

Gene Ontology (GO) - Biological Process for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B6: view

No data available for SIGNOR curated interactions for OR2B6 Gene

Drugs & Compounds for OR2B6 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OR2B6 Gene

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mRNA/cDNA for OR2B6 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2B6

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B6 Gene

No ASD Table

Relevant External Links for OR2B6 Gene

GeneLoc Exon Structure for
OR2B6

Expression for OR2B6 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2B6 Gene

mRNA expression in normal human tissues for OR2B6 Gene
mRNA expression by GTEx for OR2B6 GenemRNA expression by BioGPS for OR2B6 Gene

mRNA differential expression in normal tissues according to GTEx for OR2B6 Gene

This gene is overexpressed in Whole Blood (x12.5).

Protein differential expression in normal tissues from HIPED for OR2B6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2B6 Gene



Protein tissue co-expression partners for OR2B6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2B6

SOURCE GeneReport for Unigene cluster for OR2B6 Gene:

Hs.532145
genes like me logo Genes that share expression patterns with OR2B6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2B6 Gene

Orthologs for OR2B6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2B6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC471910 29
  • 98.83 (n)
OR2B6 30
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia OR2B6 29 30
  • 86.51 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OR2B6 30
  • 82 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Or2b6 45 Olfr11 29 16 30
  • 81.68 (n)
 OneToOne
Or2ab1 45 Olfr324
  • chr11:58,597,392-58,598,390
Or2y3 45 Olfr131
  • chr17:38,082,035-38,082,976
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 72 (a)
 ManyToMany
-- 30
  • 66 (a)
 ManyToMany
-- 30
  • 48 (a)
 ManyToMany
-- 30
  • 45 (a)
 ManyToMany
-- 30
  • 41 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 60 (a)
 ManyToMany
Species where no ortholog for OR2B6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2B6 Gene

ENSEMBL:
Gene Tree for OR2B6 (if available)
TreeFam:
Gene Tree for OR2B6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2B6: view image
Alliance of Genome Resources:
Additional Orthologs for OR2B6

Paralogs for OR2B6 Gene

Paralogs for OR2B6 Gene

(448) SIMAP similar genes for OR2B6 Gene using alignment to 1 proteins:

  • OR2B6_HUMAN

Pseudogenes.org Pseudogenes for OR2B6 Gene

genes like me logo Genes that share paralogs with OR2B6: view

Variants for OR2B6 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2B6 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs7767176 -- p.Val117Ile
rs9380030 -- p.Gln270Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2B6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2B6 Gene

Variant ID Type Subtype PubMed ID
esv3576109 CNV gain 25503493
nsv601208 CNV loss 21841781
nsv830619 CNV loss 17160897

Variation tolerance for OR2B6 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2B6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2B6
Leiden Open Variation Database (LOVD)
OR2B6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B6 Gene

Disorders for OR2B6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR2B6 Gene - From: COP

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
- elite association - COSMIC cancer census association via MalaCards
Search OR2B6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR2B6

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR2B6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2B6 Gene

Publications for OR2B6 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for OR2B6 gene in Mastermind

Products for OR2B6 Gene

Sources for OR2B6 Gene