Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2B2 Gene

Aliases for OR2B2 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 2 2 3 5
  • Hs6M1-10 2 3 4
  • OR6-1 2 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 9 2 3
  • Olfactory Receptor 2B2 3 4
  • Olfactory Receptor 2B9 3 4
  • Olfactory Receptor 6-1 3 4
  • OR2B2Q 2 3
  • OR2B9 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 2 2
  • Olfactory Receptor OR6-2 3
  • DJ193B12.4 3
  • OR2B2 5

External Ids for OR2B2 Gene

Previous HGNC Symbols for OR2B2 Gene

  • OR2B9

Previous GeneCards Identifiers for OR2B2 Gene

  • GC06M027936
  • GC06M027987
  • GC06M027895
  • GC06M027910
  • GC06M027930
  • GC06M027955
  • GC06M027972
  • GC06M027975
  • GC06M028178
  • GC06M028204
  • GC06M028211
  • GC06M028279
  • GC06M027997
  • GC06M028024
  • GC06M028041
  • GC06M028066
  • GC06M028087
  • GC06M028110
  • GC06M028135
  • GC06M028157

Summaries for OR2B2 Gene

Entrez Gene Summary for OR2B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B2 Gene

OR2B2 (Olfactory Receptor Family 2 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B6.

UniProtKB/Swiss-Prot Summary for OR2B2 Gene

Gene Wiki entry for OR2B2 Gene

Additional gene information for OR2B2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2B2 Gene

Genomics for OR2B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J027913 Enhancer 0.2 Ensembl 600.7 -1.7 -1705 0.6 OR2B2 lnc-OR2B2-1 ZNF165 OR2W6P OR2B6
GH06J027776 Enhancer 1.1 FANTOM5 ENCODE 3.3 +134.8 134753 1.7 TEAD4 ZNF512 LEF1 IKZF1 JUND PRDM1 MTA2 ZNF24 MTA1 ZNF740 TRX-CAT2-1 piR-30961-007 piR-33437-008 ZKSCAN8 ZSCAN12 ZKSCAN3 ZNF603P ZSCAN23 ZSCAN9 H4C10P
GH06J027669 Enhancer 1.2 FANTOM5 ENCODE 1.7 +243.1 243052 1.6 ZNF221 GATAD2A HNRNPL TEAD4 IKZF1 KDM1A ZNF692 RCOR2 JUND FOXA1 TRI-AAT8-1 TRR-ACG2-4 lnc-HIST1H2BL-1 piR-33415-006 piR-42844-002 ZSCAN12 ZKSCAN8 ZSCAN23 ZSCAN26 ZSCAN9
GH06J028331 Enhancer 0.2 FANTOM5 8.4 -419.3 -419251 0.4 ZNF603P ZSCAN31 GPX6 OR2B2 ZSCAN26 ZSCAN23 PGBD1 ZBED9 ZSCAN9 lnc-ZKSCAN3-2
GH06J028133 Enhancer 0.6 FANTOM5 dbSUPER 2.7 -221.0 -220994 0.2 SCRT2 SCRT1 ZKSCAN3 ZSCAN31 ZNF165 OR2B2 ZSCAN26 ZSCAN16 ZKSCAN4 ENSG00000261839 ZSCAN16-AS1 ZKSCAN8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2B2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2B2

Top Transcription factor binding sites by QIAGEN in the OR2B2 gene promoter:
  • Brachyury
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA5
  • Max1
  • Nkx3-1
  • SRY
  • USF-1
  • USF1

Genomic Locations for OR2B2 Gene

Genomic Locations for OR2B2 Gene
chr6:27,911,185-27,912,396
(GRCh38/hg38)
Size:
1,212 bases
Orientation:
Minus strand
chr6:27,878,963-27,880,174
(GRCh37/hg19)
Size:
1,212 bases
Orientation:
Minus strand

Genomic View for OR2B2 Gene

Genes around OR2B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2B2 Gene

Proteins for OR2B2 Gene

  • Protein details for OR2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK3-OR2B2_HUMAN
    Recommended name:
    Olfactory receptor 2B2
    Protein Accession:
    Q9GZK3
    Secondary Accessions:
    • B2RNH2
    • Q9GZL2
    • Q9Y299

    Protein attributes for OR2B2 Gene

    Size:
    357 amino acids
    Molecular mass:
    40412 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B2 Gene

Post-translational modifications for OR2B2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B2 Gene

Domains & Families for OR2B2 Gene

Gene Families for OR2B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2B2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR2B2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 6-1 (OR2B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZK3

UniProtKB/Swiss-Prot:

OR2B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B2: view

Function for OR2B2 Gene

Molecular function for OR2B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2B2 Gene

Gene Ontology (GO) - Molecular Function for OR2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2B2: view
genes like me logo Genes that share phenotypes with OR2B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2B2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B2 Gene

Localization for OR2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2B2 Gene

Pathways & Interactions for OR2B2 Gene

genes like me logo Genes that share pathways with OR2B2: view

Pathways by source for OR2B2 Gene

1 KEGG pathway for OR2B2 Gene

Interacting Proteins for OR2B2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000304419 Q9GZK3-OR2B2_HUMAN for OR2B2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B2: view

No data available for SIGNOR curated interactions for OR2B2 Gene

Drugs & Compounds for OR2B2 Gene

No Compound Related Data Available

Transcripts for OR2B2 Gene

mRNA/cDNA for OR2B2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2B2

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B2 Gene

No ASD Table

Relevant External Links for OR2B2 Gene

GeneLoc Exon Structure for
OR2B2

Expression for OR2B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2B2 Gene

Protein differential expression in normal tissues from HIPED for OR2B2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (43.4) and Heart (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2B2 Gene



Protein tissue co-expression partners for OR2B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2B2

SOURCE GeneReport for Unigene cluster for OR2B2 Gene:

Hs.307111
genes like me logo Genes that share expression patterns with OR2B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2B2 Gene

Orthologs for OR2B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2B2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia LOC783002 30
  • 86.26 (n)
-- 31
  • 85 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or2b2b 46 Olfr1360 17 31
  • 86 (a)
ManyToMany
Or2b2 46 Olfr1359 30 17
  • 82.53 (n)
Rat
(Rattus norvegicus)
Mammalia Olr1654 30
  • 81.72 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
ManyToMany
-- 31
  • 71 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 54 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486623 30
  • 58.58 (n)
Species where no ortholog for OR2B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2B2 Gene

ENSEMBL:
Gene Tree for OR2B2 (if available)
TreeFam:
Gene Tree for OR2B2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2B2: view image

Paralogs for OR2B2 Gene

(426) SIMAP similar genes for OR2B2 Gene using alignment to 1 proteins:

  • OR2B2_HUMAN
genes like me logo Genes that share paralogs with OR2B2: view

Variants for OR2B2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2B2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs34788973 - p.Ala300Ser
rs34957169 - p.Gln234Arg
rs9368537 - p.Ala183Pro

Additional dbSNP identifiers (rs#s) for OR2B2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2B2 Gene

Variant ID Type Subtype PubMed ID
esv2731742 CNV deletion 23290073
nsv601208 CNV loss 21841781
nsv830619 CNV loss 17160897

Variation tolerance for OR2B2 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 73.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2B2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B2 Gene

Disorders for OR2B2 Gene

No disorders were found for OR2B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2B2 Gene

Publications for OR2B2 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR2B2 Gene

Sources for OR2B2 Gene