Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2B11 Gene

Aliases for OR2B11 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 11 2 3 5
  • Olfactory Receptor 2B11 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 11 2

External Ids for OR2B11 Gene

Previous GeneCards Identifiers for OR2B11 Gene

  • GC01M244563
  • GC01M243940
  • GC01M245680
  • GC01M247614

Summaries for OR2B11 Gene

Entrez Gene Summary for OR2B11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B11 Gene

OR2B11 (Olfactory Receptor Family 2 Subfamily B Member 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B3.

UniProtKB/Swiss-Prot Summary for OR2B11 Gene

Gene Wiki entry for OR2B11 Gene

Additional gene information for OR2B11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2B11 Gene

Genomics for OR2B11 Gene

GeneHancer (GH) Regulatory Elements for OR2B11 Gene

Promoters and enhancers for OR2B11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247457 Enhancer 0.5 FANTOM5 dbSUPER 505.9 +0.6 578 0.9 STAT3 OR2B11 ENSG00000235749 ENSG00000236817 NLRP3 piR-38829
GH01J247415 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 13 +40.5 40465 5.1 TEAD4 RBM25 NBN SPI1 GABPA EBF1 IKZF1 TBP TBX21 POLR2A NLRP3 OR2B11 ZNF496 piR-38829
GH01J247401 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +56.1 56104 2.8 TCF12 FOS MAFK ARNT CTCF IKZF1 ZBTB7A RAD21 TBX21 CEBPB HSALNG0012259 NLRP3 OR2B11 OR2C3 ZNF496 OR2G3 AHCTF1 ENSG00000287116
GH01J247420 Promoter/Enhancer 0.8 Ensembl dbSUPER 13 +37.2 37204 0.6 FOS HDGF IKZF1 STAT3 OR2B11 ZNF496 NLRP3 piR-38829
GH01J247494 Enhancer 0.7 Ensembl ENCODE 12.3 -36.5 -36496 3.2 NFIC SPI1 FOSL1 STAT3 NFIB NFE2 CEBPB LCORL BHLHE40 SMAD1 OR2B11 OR2G2 OR2C3 GCSAML-AS1 OR2G3 ENSG00000235749 ENSG00000236817 ZNF496 GCSAML OR2W5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2B11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2B11

Top Transcription factor binding sites by QIAGEN in the OR2B11 gene promoter:
  • Arnt
  • c-Myc
  • C/EBPalpha
  • HTF
  • LUN-1
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • ZID

Genomic Locations for OR2B11 Gene

Genomic Locations for OR2B11 Gene
chr1:247,449,118-247,458,105
(GRCh38/hg38)
Size:
8,988 bases
Orientation:
Minus strand
chr1:247,614,255-247,615,308
(GRCh37/hg19)
Size:
1,054 bases
Orientation:
Minus strand

Genomic View for OR2B11 Gene

Genes around OR2B11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2B11 Gene

Proteins for OR2B11 Gene

  • Protein details for OR2B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQS5-OR2BB_HUMAN
    Recommended name:
    Olfactory receptor 2B11
    Protein Accession:
    Q5JQS5
    Secondary Accessions:
    • B2RP03

    Protein attributes for OR2B11 Gene

    Size:
    317 amino acids
    Molecular mass:
    35342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B11 Gene

Post-translational modifications for OR2B11 Gene

  • Glycosylation at Asn5 and Asn199
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B11 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B11 Gene

Domains & Families for OR2B11 Gene

Gene Families for OR2B11 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2B11 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR2B11 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 2B11 (OR2BB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5JQS5

UniProtKB/Swiss-Prot:

OR2BB_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B11: view

Function for OR2B11 Gene

Molecular function for OR2B11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2B11 Gene

Gene Ontology (GO) - Molecular Function for OR2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2B11: view
genes like me logo Genes that share phenotypes with OR2B11: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B11 Gene

Localization for OR2B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2B11 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for OR2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2B11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2B11 Gene

Pathways & Interactions for OR2B11 Gene

genes like me logo Genes that share pathways with OR2B11: view

Pathways by source for OR2B11 Gene

Interacting Proteins for OR2B11 Gene

;

Gene Ontology (GO) - Biological Process for OR2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B11: view

No data available for SIGNOR curated interactions for OR2B11 Gene

Drugs & Compounds for OR2B11 Gene

No Compound Related Data Available

Transcripts for OR2B11 Gene

mRNA/cDNA for OR2B11 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B11 Gene

No ASD Table

Relevant External Links for OR2B11 Gene

GeneLoc Exon Structure for
OR2B11

Expression for OR2B11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2B11 Gene

mRNA differential expression in normal tissues according to GTEx for OR2B11 Gene

This gene is overexpressed in Whole Blood (x14.2) and Adipose - Visceral (Omentum) (x6.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2B11

SOURCE GeneReport for Unigene cluster for OR2B11 Gene:

Hs.446999
genes like me logo Genes that share expression patterns with OR2B11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2B11 Gene

Orthologs for OR2B11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2B11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR2B11 31
  • 99 (a)
OneToOne
LOC469158 30
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia OR2B11 31 30
  • 86.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607036 30
  • 85.02 (n)
OR2B11 31
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or2b11 47 Olfr222 17 31 30
  • 84.02 (n)
Or2b28 47 Olfr1367
  • chr13:21,346,930-21,347,877
rat
(Rattus norvegicus)
Mammalia Olr1462 30
  • 83.28 (n)
oppossum
(Monodelphis domestica)
Mammalia OR2B11 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR2B11 31
  • 61 (a)
OneToOne
Species where no ortholog for OR2B11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2B11 Gene

ENSEMBL:
Gene Tree for OR2B11 (if available)
TreeFam:
Gene Tree for OR2B11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2B11: view image

Paralogs for OR2B11 Gene

(457) SIMAP similar genes for OR2B11 Gene using alignment to 1 proteins:

  • OR2BB_HUMAN
genes like me logo Genes that share paralogs with OR2B11: view

Variants for OR2B11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2B11 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
775699 Benign: not provided 247,451,461(-) C/T SYNONYMOUS_VARIANT
775700 Benign: not provided 247,451,482(-) C/G SYNONYMOUS_VARIANT
rs11583410 - p.Ile130Ser
rs12065526 - p.Thr293Ile
rs12070953 - p.Asp300Gly

Additional dbSNP identifiers (rs#s) for OR2B11 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2B11 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV gain+loss 17666407
nsv1011097 CNV gain 25217958

Variation tolerance for OR2B11 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.87; 99.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2B11 Gene

Human Gene Mutation Database (HGMD)
OR2B11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2B11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B11 Gene

Disorders for OR2B11 Gene

Additional Disease Information for OR2B11

No disorders were found for OR2B11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2B11 Gene

Publications for OR2B11 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W … Steffen LM (Circulation. Cardiovascular genetics 2014) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. (PMID: 19098911) Villani AC … Franchimont D (Nature genetics 2009) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for OR2B11 Gene

Sources for OR2B11 Gene