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Aliases for OR2AT4 Gene

Aliases for OR2AT4 Gene

  • Olfactory Receptor Family 2 Subfamily AT Member 4 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AT, Member 4 2
  • Olfactory Receptor OR11-265 Pseudogene 3
  • Olfactory Receptor OR11-265 4
  • Olfactory Receptor 2AT4 3
  • OR11-265 3

External Ids for OR2AT4 Gene

Previous GeneCards Identifiers for OR2AT4 Gene

  • GC00U903081
  • GC11M074527
  • GC11M074477
  • GC11M074799

Summaries for OR2AT4 Gene

Entrez Gene Summary for OR2AT4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AT4 Gene

OR2AT4 (Olfactory Receptor Family 2 Subfamily AT Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for OR2AT4 Gene

  • Odorant receptor.

Additional gene information for OR2AT4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AT4 Gene

Genomics for OR2AT4 Gene

GeneHancer (GH) Regulatory Elements for OR2AT4 Gene

Promoters and enhancers for OR2AT4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I075096 Enhancer 1.1 ENCODE dbSUPER 550.8 -0.2 -220 1.3 HDGF PKNOX1 ARNT TCF12 GATA2 ZNF592 GMEB1 SMARCA4 HMBOX1 KDM1A OR2AT4 ENSG00000255395 LOC100421207
GH11I075029 Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.2 +65.7 65670 3 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 ZNF766 E2F8 ZNF143 FOS XRRA1 ENSG00000206913 POLD3 RPS3 RNF169 P4HA3 SNORD15B OR2AT4 SLCO2B1 RN7SL239P
GH11I075022 Enhancer 1 Ensembl ENCODE 10.8 +73.5 73502 2.1 HDAC1 ATF1 RB1 ZNF2 BRCA1 ZNF48 RAD21 ZBTB40 RFX5 ARID2 SPCS2 XRRA1 OR2AT4 SLCO2B1 ENSG00000254429 NEU3 PIR50270 PIR37723 PIRC52
GH11I075044 Enhancer 0.3 ENCODE 11.1 +51.1 51107 1.6 ZBTB33 PIR37723 XRRA1 SLCO2B1 OR2AT4 OR2AT2P
GH11I075154 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 -63.4 -63444 12 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 ATF7 RXRA SP5 MXD4 SLCO2B1 C2CD3 P4HA3 ENSG00000255395 XRRA1 OR2AT4 ZDHHC20P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2AT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2AT4 gene promoter:

Genomic Locations for OR2AT4 Gene

Genomic Locations for OR2AT4 Gene
15,124 bases
Minus strand

Genomic View for OR2AT4 Gene

Genes around OR2AT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AT4 Gene

Proteins for OR2AT4 Gene

  • Protein details for OR2AT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2AT4
    Protein Accession:
    Secondary Accessions:
    • B9EGZ8

    Protein attributes for OR2AT4 Gene

    320 amino acids
    Molecular mass:
    35503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AT4 Gene

Post-translational modifications for OR2AT4 Gene

Other Protein References for OR2AT4 Gene

No data available for DME Specific Peptides for OR2AT4 Gene

Domains & Families for OR2AT4 Gene

Gene Families for OR2AT4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AT4 Gene

Suggested Antigen Peptide Sequences for OR2AT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AT4: view

Function for OR2AT4 Gene

Molecular function for OR2AT4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AT4: view
genes like me logo Genes that share phenotypes with OR2AT4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AT4 Gene

Localization for OR2AT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AT4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AT4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AT4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AT4 Gene

Pathways & Interactions for OR2AT4 Gene

genes like me logo Genes that share pathways with OR2AT4: view

Pathways by source for OR2AT4 Gene

Interacting Proteins for OR2AT4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: ENSP00000304846 A6NND4-O2AT4_HUMAN for OR2AT4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR2AT4: view

No data available for SIGNOR curated interactions for OR2AT4 Gene

Drugs & Compounds for OR2AT4 Gene

No Compound Related Data Available

Transcripts for OR2AT4 Gene

mRNA/cDNA for OR2AT4 Gene

(5) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AT4 Gene

No ASD Table

Relevant External Links for OR2AT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2AT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2AT4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2AT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2AT4 Gene:


SOURCE GeneReport for Unigene cluster for OR2AT4 Gene:

genes like me logo Genes that share expression patterns with OR2AT4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AT4 Gene

Orthologs for OR2AT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2AT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC748690 33
  • 99.06 (n)
OR2AT4 34
  • 99 (a)
(Canis familiaris)
Mammalia LOC609254 33
  • 90.83 (n)
OR2AT4 34
  • 85 (a)
(Bos Taurus)
Mammalia OR2AT4 33 34
  • 90.18 (n)
(Rattus norvegicus)
Mammalia Olr35 33
  • 85.48 (n)
(Mus musculus)
Mammalia Or2at4 51 Olfr520 33 16 34
  • 84.95 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
-- 34
  • 71 (a)
-- 34
  • 63 (a)
-- 34
  • 62 (a)
-- 34
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
(Danio rerio)
Actinopterygii or103-1 34
  • 35 (a)
or103-2 34
  • 33 (a)
or105-1 34
  • 32 (a)
or102-2 34
  • 31 (a)
or103-4 34
  • 31 (a)
or104-2 34
  • 31 (a)
or103-3 34
  • 30 (a)
or111-6 34
  • 30 (a)
or102-1 34
  • 29 (a)
or102-5 34
  • 29 (a)
or111-7 34
  • 29 (a)
or102-3 34
  • 27 (a)
or102-4 34
  • 27 (a)
or111-4 34
  • 27 (a)
or111-5 34
  • 27 (a)
or111-9 34
  • 27 (a)
or109-1 34
  • 26 (a)
or109-13 34
  • 26 (a)
or111-10 34
  • 26 (a)
or111-11 34
  • 26 (a)
or111-3 34
  • 26 (a)
or106-10 34
  • 25 (a)
or107-1 34
  • 25 (a)
or109-2 34
  • 25 (a)
or111-1 34
  • 25 (a)
or111-2 34
  • 25 (a)
BX088524.1 34
  • 24 (a)
or108-1 34
  • 24 (a)
or109-11 34
  • 24 (a)
or109-5 34
  • 24 (a)
or111-8 34
  • 24 (a)
or108-3 34
  • 23 (a)
or109-4 34
  • 23 (a)
or110-1 34
  • 23 (a)
or110-2 34
  • 23 (a)
or106-1 34
  • 22 (a)
Species where no ortholog for OR2AT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR2AT4 Gene

Gene Tree for OR2AT4 (if available)
Gene Tree for OR2AT4 (if available)

Paralogs for OR2AT4 Gene

(458) SIMAP similar genes for OR2AT4 Gene using alignment to 1 proteins: Pseudogenes for OR2AT4 Gene

genes like me logo Genes that share paralogs with OR2AT4: view

No data available for Paralogs for OR2AT4 Gene

Variants for OR2AT4 Gene

Sequence variations from dbSNP and Humsavar for OR2AT4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000691923 -- 75,095,015(-) G/A genic_upstream_transcript_variant, intron_variant
rs1001222369 -- 75,094,654(-) A/G genic_upstream_transcript_variant, intron_variant
rs1001444272 -- 75,098,565(-) C/ genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001673348 -- 75,089,396(-) C/T coding_sequence_variant, missense_variant
rs1001827432 -- 75,095,813(-) G/A genic_upstream_transcript_variant, intron_variant

Variation tolerance for OR2AT4 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2AT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR2AT4 Gene

Disorders for OR2AT4 Gene

Additional Disease Information for OR2AT4

No disorders were found for OR2AT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AT4 Gene

Publications for OR2AT4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. (PMID: 24999593) Busse D … Benecke H (The Journal of investigative dermatology 2014) 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr RH … Cho JH (Science (New York, N.Y.) 2006) 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OR2AT4 Gene

Sources for OR2AT4 Gene

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