Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2AT4 Gene

Aliases for OR2AT4 Gene

  • Olfactory Receptor Family 2 Subfamily AT Member 4 2 3 5
  • Olfactory Receptor 2AT4 3 4
  • Olfactory Receptor, Family 2, Subfamily AT, Member 4 2
  • Olfactory Receptor OR11-265 Pseudogene 3
  • Olfactory Receptor OR11-265 4
  • OR11-265 3

External Ids for OR2AT4 Gene

Previous GeneCards Identifiers for OR2AT4 Gene

  • GC00U903081
  • GC11M074527
  • GC11M074477
  • GC11M074799

Summaries for OR2AT4 Gene

Entrez Gene Summary for OR2AT4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AT4 Gene

OR2AT4 (Olfactory Receptor Family 2 Subfamily AT Member 4) is a Protein Coding gene. Diseases associated with OR2AT4 include Telogen Effluvium. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1L6.

UniProtKB/Swiss-Prot Summary for OR2AT4 Gene

  • Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is propably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264).

Additional gene information for OR2AT4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2AT4 Gene

Genomics for OR2AT4 Gene

GeneHancer (GH) Regulatory Elements for OR2AT4 Gene

Promoters and enhancers for OR2AT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2AT4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2AT4

Top Transcription factor binding sites by QIAGEN in the OR2AT4 gene promoter:
  • AML1a
  • CUTL1
  • Hlf
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • SRF
  • SRF (504 AA)

Genomic Locations for OR2AT4 Gene

Genomic Locations for OR2AT4 Gene
chr11:75,081,753-75,096,876
(GRCh38/hg38)
Size:
15,124 bases
Orientation:
Minus strand
chr11:74,799,758-74,800,799
(GRCh37/hg19)
Size:
1,042 bases
Orientation:
Minus strand

Genomic View for OR2AT4 Gene

Genes around OR2AT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AT4 Gene

Proteins for OR2AT4 Gene

  • Protein details for OR2AT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NND4-O2AT4_HUMAN
    Recommended name:
    Olfactory receptor 2AT4
    Protein Accession:
    A6NND4
    Secondary Accessions:
    • B9EGZ8

    Protein attributes for OR2AT4 Gene

    Size:
    320 amino acids
    Molecular mass:
    35503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AT4 Gene

Post-translational modifications for OR2AT4 Gene

  • Glycosylation at Asn7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2AT4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AT4 Gene

Domains & Families for OR2AT4 Gene

Gene Families for OR2AT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AT4 Gene

Suggested Antigen Peptide Sequences for OR2AT4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-265 (O2AT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NND4

UniProtKB/Swiss-Prot:

O2AT4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AT4: view

Function for OR2AT4 Gene

Molecular function for OR2AT4 Gene

UniProtKB/Swiss-Prot Function:
Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is propably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264).
UniProtKB/Swiss-Prot Induction:
Down-regulated during spontaneous, apoptosis-driven hair follicles regression (catagen).

Gene Ontology (GO) - Molecular Function for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IDA 24999593
genes like me logo Genes that share ontologies with OR2AT4: view
genes like me logo Genes that share phenotypes with OR2AT4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AT4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AT4 Gene

Localization for OR2AT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AT4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AT4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2AT4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AT4 Gene

Pathways & Interactions for OR2AT4 Gene

genes like me logo Genes that share pathways with OR2AT4: view

Pathways by source for OR2AT4 Gene

Interacting Proteins for OR2AT4 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000304846 A6NND4-O2AT4_HUMAN for OR2AT4 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AT4: view

No data available for SIGNOR curated interactions for OR2AT4 Gene

Drugs & Compounds for OR2AT4 Gene

No Compound Related Data Available

Transcripts for OR2AT4 Gene

mRNA/cDNA for OR2AT4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AT4

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AT4 Gene

No ASD Table

Relevant External Links for OR2AT4 Gene

GeneLoc Exon Structure for
OR2AT4

Expression for OR2AT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2AT4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2AT4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2AT4

SOURCE GeneReport for Unigene cluster for OR2AT4 Gene:

Hs.554515

mRNA Expression by UniProt/SwissProt for OR2AT4 Gene:

A6NND4-O2AT4_HUMAN
Tissue specificity: Detected in the keratinocytes of the epidermis (at protein level) (PubMed:24999593). Detected in hair follicles in proximal outer root sheath and hair matrix keratinocytes (at protein level) (PubMed:30228264).
genes like me logo Genes that share expression patterns with OR2AT4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AT4 Gene

Orthologs for OR2AT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2AT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748690 30
  • 99.06 (n)
OR2AT4 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609254 30
  • 90.83 (n)
OR2AT4 31
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2AT4 31 30
  • 90.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr35 30
  • 85.48 (n)
mouse
(Mus musculus)
Mammalia Or2at4 47 Olfr520 17 31 30
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
-- 31
  • 62 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii or103-1 31
  • 35 (a)
ManyToMany
or103-2 31
  • 33 (a)
ManyToMany
or105-1 31
  • 32 (a)
ManyToMany
or104-2 31
  • 31 (a)
ManyToMany
or102-2 31
  • 31 (a)
ManyToMany
or103-4 31
  • 31 (a)
ManyToMany
or111-6 31
  • 30 (a)
ManyToMany
or103-3 31
  • 30 (a)
ManyToMany
or102-5 31
  • 29 (a)
ManyToMany
or111-7 31
  • 29 (a)
ManyToMany
or102-1 31
  • 29 (a)
ManyToMany
or111-5 31
  • 27 (a)
ManyToMany
or102-3 31
  • 27 (a)
ManyToMany
or111-9 31
  • 27 (a)
ManyToMany
or102-4 31
  • 27 (a)
ManyToMany
or111-4 31
  • 27 (a)
ManyToMany
or111-3 31
  • 26 (a)
ManyToMany
or109-13 31
  • 26 (a)
ManyToMany
or111-10 31
  • 26 (a)
ManyToMany
or109-1 31
  • 26 (a)
ManyToMany
or111-11 31
  • 26 (a)
ManyToMany
or109-2 31
  • 25 (a)
ManyToMany
or107-1 31
  • 25 (a)
ManyToMany
or111-2 31
  • 25 (a)
ManyToMany
or111-1 31
  • 25 (a)
ManyToMany
or106-10 31
  • 25 (a)
ManyToMany
BX088524.1 31
  • 24 (a)
ManyToMany
or108-1 31
  • 24 (a)
ManyToMany
or109-11 31
  • 24 (a)
ManyToMany
or111-8 31
  • 24 (a)
ManyToMany
or109-5 31
  • 24 (a)
ManyToMany
or109-4 31
  • 23 (a)
ManyToMany
or110-1 31
  • 23 (a)
ManyToMany
or110-2 31
  • 23 (a)
ManyToMany
or108-3 31
  • 23 (a)
ManyToMany
or106-1 31
  • 22 (a)
ManyToMany
Species where no ortholog for OR2AT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR2AT4 Gene

ENSEMBL:
Gene Tree for OR2AT4 (if available)
TreeFam:
Gene Tree for OR2AT4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2AT4: view image

Paralogs for OR2AT4 Gene

(458) SIMAP similar genes for OR2AT4 Gene using alignment to 1 proteins:

  • O2AT4_HUMAN

Pseudogenes.org Pseudogenes for OR2AT4 Gene

genes like me logo Genes that share paralogs with OR2AT4: view

Variants for OR2AT4 Gene

Additional dbSNP identifiers (rs#s) for OR2AT4 Gene

Variation tolerance for OR2AT4 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2AT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for OR2AT4 Gene

Disorders for OR2AT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR2AT4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
telogen effluvium
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR2AT4

genes like me logo Genes that share disorders with OR2AT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2AT4 Gene

Publications for OR2AT4 Gene

  1. Olfactory receptor OR2AT4 regulates human hair growth. (PMID: 30228264) Chéret J … Paus R (Nature communications 2018) 3 4 54
  2. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. (PMID: 24999593) Busse D … Benecke H (The Journal of investigative dermatology 2014) 3 4 54
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54

Products for OR2AT4 Gene

Sources for OR2AT4 Gene