Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2AP1 Gene

Aliases for OR2AP1 Gene

  • Olfactory Receptor Family 2 Subfamily AP Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AP, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-9 3 4
  • Olfactory Receptor 2AP1 3 4
  • OR2AP1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AP, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • OR2AP1 5

External Ids for OR2AP1 Gene

Previous HGNC Symbols for OR2AP1 Gene

  • OR2AP1P

Previous GeneCards Identifiers for OR2AP1 Gene

  • GC12P054255
  • GC12P054256
  • GC12P055968

Summaries for OR2AP1 Gene

Entrez Gene Summary for OR2AP1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AP1 Gene

OR2AP1 (Olfactory Receptor Family 2 Subfamily AP Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C4.

UniProtKB/Swiss-Prot Summary for OR2AP1 Gene

Gene Wiki entry for OR2AP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2AP1 Gene

Genomics for OR2AP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2AP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055619 Enhancer 1 Ensembl ENCODE 0.3 +47.3 47333 0.8 ZNF654 MYC JUND CEBPA CTCF REST CEBPB DEK TRIM22 MNT HSALNG0091420 piR-56341-037 OR10P1 ENSG00000258763 OR2AP1
GH12J055624 Enhancer 0.9 Ensembl ENCODE 0.2 +51.8 51833 0.6 SP1 BCL11A TRIM22 IRF4 EBF1 CBFB BHLHE40 BATF STAT5A IKZF1 HSALNG0091420 ENSG00000258763 OR10P1 piR-56341-037 OR2AP1
GH12J055631 Enhancer 0.4 dbSUPER 0.2 +59.9 59887 2.6 ATF2 HMBOX1 SCRT2 OR10P1 ENSG00000258763 HSALNG0091420 OR2AP1
GH12J055606 Enhancer 0.3 Ensembl 0.3 +35.8 35833 0.6 SPI1 OR6U2P piR-56341-037 OR10P1 ENSG00000258763 OR2AP1
GH12J055629 Enhancer 0.3 FANTOM5 dbSUPER 0.2 +56.8 56814 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2AP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2AP1

Genomic Locations for OR2AP1 Gene

Latest Assembly
chr12:55,572,468-55,575,612
(GRCh38/hg38)
Size:
3,145 bases
Orientation:
Plus strand

Previous Assembly
chr12:55,966,252-55,969,396
(GRCh37/hg19 by Entrez Gene)
Size:
3,145 bases
Orientation:
Plus strand

chr12:55,968,199-55,969,128
(GRCh37/hg19 by Ensembl)
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR2AP1 Gene

Genes around OR2AP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AP1 Gene

Proteins for OR2AP1 Gene

  • Protein details for OR2AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE2-O2AP1_HUMAN
    Recommended name:
    Olfactory receptor 2AP1
    Protein Accession:
    Q8NGE2

    Protein attributes for OR2AP1 Gene

    Size:
    309 amino acids
    Molecular mass:
    34902 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AP1 Gene

Post-translational modifications for OR2AP1 Gene

  • Glycosylation at Asn3 and Asn87

Other Protein References for OR2AP1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AP1 Gene

Domains & Families for OR2AP1 Gene

Gene Families for OR2AP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AP1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2AP1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-9 (O2AP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE2

UniProtKB/Swiss-Prot:

O2AP1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AP1: view

Function for OR2AP1 Gene

Molecular function for OR2AP1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2AP1 Gene

Gene Ontology (GO) - Molecular Function for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR2AP1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AP1 Gene

Localization for OR2AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AP1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AP1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AP1 Gene

Pathways & Interactions for OR2AP1 Gene

genes like me logo Genes that share pathways with OR2AP1: view

Pathways by source for OR2AP1 Gene

Interacting Proteins for OR2AP1 Gene

Gene Ontology (GO) - Biological Process for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

No data available for SIGNOR curated interactions for OR2AP1 Gene

Drugs & Compounds for OR2AP1 Gene

No Compound Related Data Available

Transcripts for OR2AP1 Gene

mRNA/cDNA for OR2AP1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AP1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AP1 Gene

No ASD Table

Relevant External Links for OR2AP1 Gene

GeneLoc Exon Structure for
OR2AP1

Expression for OR2AP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2AP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2AP1

SOURCE GeneReport for Unigene cluster for OR2AP1 Gene:

Hs.742584
genes like me logo Genes that share expression patterns with OR2AP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AP1 Gene

Orthologs for OR2AP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC467025 29
  • 99.03 (n)
OR2AP1 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC515967 29
  • 87.92 (n)
OR2AP1 30
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or2ap1b 45 Olfr765 16 30
  • 87 (a)
OneToMany
Or2ap1 45 Olfr767 29 16 30
  • 86.19 (n)
OneToMany
Or6c33 45 Olfr820
  • chr10:130,017,363-130,018,298
Rat
(Rattus norvegicus)
Mammalia Olr878 29
  • 86.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 74 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 68 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 64 (a)
ManyToMany
Species where no ortholog for OR2AP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2AP1 Gene

ENSEMBL:
Gene Tree for OR2AP1 (if available)
TreeFam:
Gene Tree for OR2AP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2AP1: view image
Alliance of Genome Resources:
Additional Orthologs for OR2AP1

Paralogs for OR2AP1 Gene

(452) SIMAP similar genes for OR2AP1 Gene using alignment to 1 proteins:

  • O2AP1_HUMAN

Pseudogenes.org Pseudogenes for OR2AP1 Gene

genes like me logo Genes that share paralogs with OR2AP1: view

Variants for OR2AP1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2AP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2AP1 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR2AP1 Gene

Gene Damage Index Score: 5.55; 72.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2AP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AP1
Leiden Open Variation Database (LOVD)
OR2AP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2AP1 Gene

Disorders for OR2AP1 Gene

Additional Disease Information for OR2AP1

No disorders were found for OR2AP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AP1 Gene

Publications for OR2AP1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2AP1 Gene

Sources for OR2AP1 Gene