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Aliases for OR2AP1 Gene

Aliases for OR2AP1 Gene

  • Olfactory Receptor Family 2 Subfamily AP Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AP, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-9 3 4
  • OR2AP1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AP, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 2AP1 3

External Ids for OR2AP1 Gene

Previous HGNC Symbols for OR2AP1 Gene

  • OR2AP1P

Previous GeneCards Identifiers for OR2AP1 Gene

  • GC12P054255
  • GC12P054256
  • GC12P055968

Summaries for OR2AP1 Gene

Entrez Gene Summary for OR2AP1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AP1 Gene

OR2AP1 (Olfactory Receptor Family 2 Subfamily AP Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C4.

UniProtKB/Swiss-Prot for OR2AP1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AP1 Gene

Additional gene information for OR2AP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AP1 Gene

Genomics for OR2AP1 Gene

Genomic Locations for OR2AP1 Gene

Genomic Locations for OR2AP1 Gene
3,145 bases
Plus strand
930 bases
Plus strand

Genomic View for OR2AP1 Gene

Genes around OR2AP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AP1 Gene

No data available for GeneHancer (GH) Regulatory Elements for OR2AP1 Gene

Proteins for OR2AP1 Gene

  • Protein details for OR2AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2AP1
    Protein Accession:

    Protein attributes for OR2AP1 Gene

    309 amino acids
    Molecular mass:
    34902 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AP1 Gene

Post-translational modifications for OR2AP1 Gene

  • Glycosylation at isoforms=87 and isoforms=3

Other Protein References for OR2AP1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AP1 Gene

Domains & Families for OR2AP1 Gene

Gene Families for OR2AP1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AP1 Gene

Suggested Antigen Peptide Sequences for OR2AP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AP1: view

Function for OR2AP1 Gene

Molecular function for OR2AP1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AP1 Gene

Localization for OR2AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AP1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AP1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AP1 Gene

Pathways & Interactions for OR2AP1 Gene

genes like me logo Genes that share pathways with OR2AP1: view

Pathways by source for OR2AP1 Gene

Interacting Proteins for OR2AP1 Gene

Gene Ontology (GO) - Biological Process for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

No data available for SIGNOR curated interactions for OR2AP1 Gene

Drugs & Compounds for OR2AP1 Gene

No Compound Related Data Available

Transcripts for OR2AP1 Gene

mRNA/cDNA for OR2AP1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2AP1 Gene

Olfactory receptor, family 2, subfamily AP, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AP1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AP1 Gene

No ASD Table

Relevant External Links for OR2AP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2AP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2AP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2AP1 Gene:


SOURCE GeneReport for Unigene cluster for OR2AP1 Gene:

genes like me logo Genes that share expression patterns with OR2AP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AP1 Gene

Orthologs for OR2AP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC467025 33
  • 99.03 (n)
OR2AP1 34
  • 98 (a)
(Bos Taurus)
Mammalia LOC515967 33
  • 87.92 (n)
OR2AP1 34
  • 85 (a)
(Mus musculus)
Mammalia Or2ap1b 51 Olfr765 34
  • 87 (a)
Or2ap1 51 Olfr767 16 34 33
  • 86.19 (n)
Or6c33 51 Olfr820
  • chr10:130,017,363-130,018,298
(Rattus norvegicus)
Mammalia Olr878 33
  • 86.47 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 69 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
(Canis familiaris)
Mammalia -- 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
Species where no ortholog for OR2AP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AP1 Gene

Gene Tree for OR2AP1 (if available)
Gene Tree for OR2AP1 (if available)
Evolutionary constrained regions (ECRs) for OR2AP1: view image

Paralogs for OR2AP1 Gene

Paralogs for OR2AP1 Gene

(452) SIMAP similar genes for OR2AP1 Gene using alignment to 1 proteins:

  • O2AP1_HUMAN Pseudogenes for OR2AP1 Gene

genes like me logo Genes that share paralogs with OR2AP1: view

Variants for OR2AP1 Gene

Sequence variations from dbSNP and Humsavar for OR2AP1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001586695 -- 55,572,937(+) C/T upstream_transcript_variant
rs1001675392 -- 55,572,622(+) G/A upstream_transcript_variant
rs1001931031 -- 55,572,754(+) A/G upstream_transcript_variant
rs1004616964 -- 55,573,917(+) A/C upstream_transcript_variant
rs1006221305 -- 55,573,767(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2AP1 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR2AP1 Gene

Gene Damage Index Score: 5.55; 72.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2AP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2AP1 Gene

Disorders for OR2AP1 Gene

Additional Disease Information for OR2AP1

No disorders were found for OR2AP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AP1 Gene

Publications for OR2AP1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2AP1 Gene

Sources for OR2AP1 Gene

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