Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2AG2 Gene

Aliases for OR2AG2 Gene

  • Olfactory Receptor Family 2 Subfamily AG Member 2 2 3 5
  • Olfactory Receptor 2AG2 3 4
  • OR2AG2P 3 4
  • Olfactory Receptor, Family 2, Subfamily AG, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily AG, Member 2 2
  • Olfactory Receptor OR11-76 Pseudogene 3
  • OR11-76 3

External Ids for OR2AG2 Gene

Previous HGNC Symbols for OR2AG2 Gene

  • OR2AG2P

Previous GeneCards Identifiers for OR2AG2 Gene

  • GC11M006754
  • GC11M006745
  • GC11M006790

Summaries for OR2AG2 Gene

Entrez Gene Summary for OR2AG2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AG2 Gene

OR2AG2 (Olfactory Receptor Family 2 Subfamily AG Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2AG1.

UniProtKB/Swiss-Prot Summary for OR2AG2 Gene

Additional gene information for OR2AG2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2AG2 Gene

Genomics for OR2AG2 Gene

GeneHancer (GH) Regulatory Elements for OR2AG2 Gene

Promoters and enhancers for OR2AG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2AG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2AG2

Top Transcription factor binding sites by QIAGEN in the OR2AG2 gene promoter:
  • Arnt
  • C/EBPbeta
  • GATA-3
  • NF-kappaB
  • NF-kappaB1
  • Sox9
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • USF1

Genomic Locations for OR2AG2 Gene

Genomic Locations for OR2AG2 Gene
chr11:6,765,626-6,926,426
(GRCh38/hg38)
Size:
160,801 bases
Orientation:
Minus strand
chr11:6,789,218-6,790,286
(GRCh37/hg19)
Size:
1,069 bases
Orientation:
Minus strand

Genomic View for OR2AG2 Gene

Genes around OR2AG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AG2 Gene

Proteins for OR2AG2 Gene

  • Protein details for OR2AG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NM03-O2AG2_HUMAN
    Recommended name:
    Olfactory receptor 2AG2
    Protein Accession:
    A6NM03
    Secondary Accessions:
    • B9EIM0

    Protein attributes for OR2AG2 Gene

    Size:
    316 amino acids
    Molecular mass:
    35270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AG2 Gene

Post-translational modifications for OR2AG2 Gene

  • Glycosylation at Asn5 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2AG2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AG2 Gene

Domains & Families for OR2AG2 Gene

Gene Families for OR2AG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AG2 Gene

Suggested Antigen Peptide Sequences for OR2AG2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 2, subfamily AG, member 2 (B9EIM0_HUMAN)
  • Olfactory receptor 2AG2 (O2AG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NM03

UniProtKB/Swiss-Prot:

O2AG2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AG2: view

Function for OR2AG2 Gene

Molecular function for OR2AG2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2AG2 Gene

Gene Ontology (GO) - Molecular Function for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AG2: view
genes like me logo Genes that share phenotypes with OR2AG2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AG2 Gene

Localization for OR2AG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AG2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AG2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2AG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AG2 Gene

Pathways & Interactions for OR2AG2 Gene

genes like me logo Genes that share pathways with OR2AG2: view

Pathways by source for OR2AG2 Gene

Interacting Proteins for OR2AG2 Gene

;

Gene Ontology (GO) - Biological Process for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AG2: view

No data available for SIGNOR curated interactions for OR2AG2 Gene

Drugs & Compounds for OR2AG2 Gene

No Compound Related Data Available

Transcripts for OR2AG2 Gene

mRNA/cDNA for OR2AG2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AG2 Gene

No ASD Table

Relevant External Links for OR2AG2 Gene

GeneLoc Exon Structure for
OR2AG2

Expression for OR2AG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2AG2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2AG2 Gene

This gene is overexpressed in Testis (x4.5), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2AG2

SOURCE GeneReport for Unigene cluster for OR2AG2 Gene:

Hs.534614
genes like me logo Genes that share expression patterns with OR2AG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AG2 Gene

Orthologs for OR2AG2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466416 30
  • 98.63 (n)
OR2AG2 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cOR2AG1 30
  • 84.23 (n)
-- 31
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR2AG1 30
  • 83.76 (n)
-- 31
  • 83 (a)
ManyToMany
-- 31
  • 82 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or2ag2 47 Olfr706 31
  • 82 (a)
ManyToMany
Or2ag2b 47 Olfr701 17 31 30
  • 81.75 (n)
Olfr705 31
  • 80 (a)
ManyToMany
Olfr700 31
  • 78 (a)
ManyToMany
Olfr694 31
  • 77 (a)
ManyToMany
Olfr698 31
  • 77 (a)
ManyToMany
Olfr695 31
  • 75 (a)
ManyToMany
Olfr704 31
  • 75 (a)
ManyToMany
Or2ag19 47 Olfr703 31
  • 74 (a)
ManyToMany
Olfr693 31
  • 73 (a)
ManyToMany
Or2ag15 47 Olfr697 31
  • 73 (a)
ManyToMany
Olfr699 31
  • 72 (a)
ManyToMany
Or2ag14-ps 47 Olfr696-ps1
  • chr7:106,728,914-106,729,819
rat
(Rattus norvegicus)
Mammalia Olr210 30
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 49 (a)
OneToMany
Species where no ortholog for OR2AG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AG2 Gene

ENSEMBL:
Gene Tree for OR2AG2 (if available)
TreeFam:
Gene Tree for OR2AG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2AG2: view image

Paralogs for OR2AG2 Gene

(451) SIMAP similar genes for OR2AG2 Gene using alignment to 2 proteins:

  • O2AG2_HUMAN
  • B9EIM0_HUMAN
genes like me logo Genes that share paralogs with OR2AG2: view

Variants for OR2AG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2AG2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10839616 - p.Arg54Pro
rs11828782 - p.Arg87Leu
rs7102536 - p.Tyr28Cys
rs7924459 - p.Arg299Gly

Additional dbSNP identifiers (rs#s) for OR2AG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2AG2 Gene

Variant ID Type Subtype PubMed ID
dgv1055n100 CNV loss 25217958
dgv1056n100 CNV loss 25217958
dgv1625n54 CNV loss 21841781
dgv1626n54 CNV loss 21841781
esv3579329 CNV loss 25503493
nsv1035138 CNV gain 25217958
nsv1043006 CNV loss 25217958
nsv1046129 CNV loss 25217958
nsv467701 CNV loss 19166990
nsv832060 CNV gain 17160897
nsv971984 CNV duplication 23825009

Variation tolerance for OR2AG2 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2AG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2AG2 Gene

Disorders for OR2AG2 Gene

Additional Disease Information for OR2AG2

No disorders were found for OR2AG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AG2 Gene

Publications for OR2AG2 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for OR2AG2 Gene

Sources for OR2AG2 Gene