Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2AE1 Gene

Aliases for OR2AE1 Gene

  • Olfactory Receptor Family 2 Subfamily AE Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AE, Member 2 2 3
  • Olfactory Receptor 2AE1 3 4
  • Olfactory Receptor 2AE2 3 4
  • OR2AE2 3 4
  • Olfactory Receptor, Family 2, Subfamily AE, Member 1 2
  • OR2AE1 5

External Ids for OR2AE1 Gene

Previous HGNC Symbols for OR2AE1 Gene

  • OR2AE2

Previous GeneCards Identifiers for OR2AE1 Gene

  • GC07U990316
  • GC07M099119
  • GC07M099120
  • GC07M099311
  • GC07M099473

Summaries for OR2AE1 Gene

Entrez Gene Summary for OR2AE1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AE1 Gene

OR2AE1 (Olfactory Receptor Family 2 Subfamily AE Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2AJ1.

UniProtKB/Swiss-Prot Summary for OR2AE1 Gene

Gene Wiki entry for OR2AE1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2AE1 Gene

Genomics for OR2AE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2AE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J099876 Enhancer 0.6 Ensembl 250.7 +0.3 257 0.8 REST CTCF SPI1 MYC MEIS2 RAD21 CTBP1 ZBTB33 PKNOX1 HDAC2 HSALNG0059934 OR2AE1 lnc-CYP3A43-4 TRIM4 CYP3A43 RF00017-5946
GH07J099826 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.8 +45.4 45439 10.8 MYC NCOR1 IKZF1 ZNF592 ZMYM3 CEBPA ATF3 NFIC YY1 MXD4 CYP3A43 TRIM4 ZSCAN25 RNF14P3 TRRAP PTCD1 GIGYF1 PPP1R35 ZNF655 PILRB
GH07J099272 Enhancer 0.9 ENCODE 5.1 +603.2 603181 2.3 IKZF1 REST CTCF ZNF217 HES1 CTBP1 SAP130 RAD21 NKRF SMC3 ZSCAN25 ZNF655 TRIM4 PTCD1 ZNF3 TRRAP RNF14P3 ZNF394 AP4M1 ENSG00000242798
GH07J099223 Enhancer 1.1 ENCODE dbSUPER 3.9 +652.1 652113 1.9 IKZF1 ZNF600 ZNF10 CEBPB BHLHE40 ZEB1 MAX EP300 NONO NKRF ZSCAN25 SMURF1 PTCD1 TRIM4 TRRAP ZNF655 AP4M1 RNF14P3 ZNF3 ENSG00000242798
GH07J100343 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 2.2 -468.0 -467975 3 SP1 ZNF207 ZNF654 NCOR1 ZNF600 JUND ZNF592 ATF2 ZNF10 CTCF HSALNG0059997 PILRA MBLAC1 ZCWPW1 MEPCE FAM200A LAMTOR4 ENSG00000241357 GPC2 GAL3ST4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2AE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2AE1

Top Transcription factor binding sites by QIAGEN in the OR2AE1 gene promoter:
  • CUTL1

Genomic Locations for OR2AE1 Gene

Latest Assembly
chr7:99,875,987-99,877,057
(GRCh38/hg38)
Size:
1,071 bases
Orientation:
Minus strand

Previous Assembly
chr7:99,473,685-99,474,656
(GRCh37/hg19 by Entrez Gene)
Size:
972 bases
Orientation:
Minus strand

chr7:99,473,610-99,474,680
(GRCh37/hg19 by Ensembl)
Size:
1,071 bases
Orientation:
Minus strand

Genomic View for OR2AE1 Gene

Genes around OR2AE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AE1 Gene

Proteins for OR2AE1 Gene

  • Protein details for OR2AE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHA4-O2AE1_HUMAN
    Recommended name:
    Olfactory receptor 2AE1
    Protein Accession:
    Q8NHA4
    Secondary Accessions:
    • B2RPD2

    Protein attributes for OR2AE1 Gene

    Size:
    323 amino acids
    Molecular mass:
    36588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AE1 Gene

Post-translational modifications for OR2AE1 Gene

  • Glycosylation at Asn5

Other Protein References for OR2AE1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AE1 Gene

Domains & Families for OR2AE1 Gene

Gene Families for OR2AE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AE1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2AE1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 2AE2 (O2AE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHA4

UniProtKB/Swiss-Prot:

O2AE1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AE1: view

Function for OR2AE1 Gene

Molecular function for OR2AE1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2AE1 Gene

Gene Ontology (GO) - Molecular Function for OR2AE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AE1: view
genes like me logo Genes that share phenotypes with OR2AE1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AE1 Gene

Localization for OR2AE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AE1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AE1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2AE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AE1 Gene

Pathways & Interactions for OR2AE1 Gene

genes like me logo Genes that share pathways with OR2AE1: view

Pathways by source for OR2AE1 Gene

Interacting Proteins for OR2AE1 Gene

Gene Ontology (GO) - Biological Process for OR2AE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AE1: view

No data available for SIGNOR curated interactions for OR2AE1 Gene

Drugs & Compounds for OR2AE1 Gene

No Compound Related Data Available

Transcripts for OR2AE1 Gene

mRNA/cDNA for OR2AE1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2AE1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AE1 Gene

No ASD Table

Relevant External Links for OR2AE1 Gene

GeneLoc Exon Structure for
OR2AE1

Expression for OR2AE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2AE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2AE1

SOURCE GeneReport for Unigene cluster for OR2AE1 Gene:

Hs.647523
genes like me logo Genes that share expression patterns with OR2AE1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AE1 Gene

Orthologs for OR2AE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR2AE1 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR2AE1 29 30
  • 87.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100686764 29
  • 87.21 (n)
OR2AE1 30
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 50 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 48 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr332 30
  • 45 (a)
ManyToMany
Species where no ortholog for OR2AE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2AE1 Gene

ENSEMBL:
Gene Tree for OR2AE1 (if available)
TreeFam:
Gene Tree for OR2AE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2AE1: view image
Alliance of Genome Resources:
Additional Orthologs for OR2AE1

Paralogs for OR2AE1 Gene

(427) SIMAP similar genes for OR2AE1 Gene using alignment to 1 proteins:

  • O2AE1_HUMAN
genes like me logo Genes that share paralogs with OR2AE1: view

Variants for OR2AE1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2AE1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs17161997 -- p.Leu267Val
rs2572023 -- p.Ile77Thr
rs60737583 -- p.Tyr217Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2AE1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR2AE1 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2AE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AE1
Leiden Open Variation Database (LOVD)
OR2AE1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR2AE1 Gene

Disorders for OR2AE1 Gene

Additional Disease Information for OR2AE1

No disorders were found for OR2AE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AE1 Gene

Publications for OR2AE1 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. Sequence diversity and haplotype structure at the human CYP3A cluster. (PMID: 16314882) Thompson EE … Di Rienzo A (The pharmacogenomics journal 2006) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  5. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3

Products for OR2AE1 Gene

Sources for OR2AE1 Gene