Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2A5 Gene

Aliases for OR2A5 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 5 2 3 5
  • Olfactory Receptor 7-138/7-141 3 4
  • Olfactory Receptor 2A26 3 4
  • Olfactory Receptor 2A5 3 4
  • Olfactory Receptor 2A8 3 4
  • OR7-138 3 4
  • OR7-141 3 4
  • OR2A26 3 4
  • OR2A8 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 26 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 8 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 5 2
  • OR2A11P 3

External Ids for OR2A5 Gene

Previous HGNC Symbols for OR2A5 Gene

  • OR2A8
  • OR2A26

Previous GeneCards Identifiers for OR2A5 Gene

  • GC07U990161
  • GC07M141994
  • GC07P143207
  • GC07P143406
  • GC07Ph42714
  • GC07Ph43185
  • GC07P143378
  • GC07P143747
  • GC07P144050
  • GC07P144251
  • GC07P144383
  • GC07P144512
  • GC07P144053
  • GC07P144122

Summaries for OR2A5 Gene

Entrez Gene Summary for OR2A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A5 Gene

OR2A5 (Olfactory Receptor Family 2 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A1.

UniProtKB/Swiss-Prot Summary for OR2A5 Gene

Gene Wiki entry for OR2A5 Gene

Additional gene information for OR2A5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2A5 Gene

Genomics for OR2A5 Gene

GeneHancer (GH) Regulatory Elements for OR2A5 Gene

Promoters and enhancers for OR2A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J144018 Enhancer 0.9 Ensembl ENCODE 11.6 -28.8 -28839 3.4 JUND FOS RFX1 CUX1 TEAD1 CTBP1 FOSL2 CEBPB JUN FOSL1 ARHGEF35 OR2A5 OR2F1 ENSG00000253882 lnc-OR6B1-1 HSALNG0061982
GH07J143989 Enhancer 0.9 Ensembl ENCODE 10.7 -59.6 -59618 0.7 CTBP1 NCOR1 NFIC TRIM24 TRIM28 PBX2 EHMT2 TAL1 NR2F1 STAT5A OR2F1 OR2A5 ARHGEF35 SLC16A1P1 lnc-OR6B1-2 piR-30350-059 lnc-OR2F1-1
GH07J143972 Enhancer 0.8 Ensembl ENCODE 10.7 -74.8 -74832 2.3 ZNF217 TCF12 ZNF830 CTBP1 FOSL2 CEBPB RBBP5 JUND ELF1 GATA3 OR6B1 OR2A5 CAPZA1P5 lnc-OR2F1-1 OR2F1
GH07J143929 Enhancer 0.5 ENCODE 9.8 -119.1 -119073 1 EP300 JUND MCM3 FOSL1 BATF FOS PKNOX1 ARHGEF35 OR2A1 OR2F1 CASP2 TCAF1 ENSG00000253882 OR2A5 OR2F2
GH07J143988 Enhancer 0.3 Ensembl 10.7 -60.6 -60647 0.2 GLIS1 OR2F1 OR2A5 SLC16A1P1 lnc-OR6B1-2 piR-30350-059 lnc-OR2F1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2A5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2A5

Top Transcription factor binding sites by QIAGEN in the OR2A5 gene promoter:
  • AREB6
  • GATA-1
  • GATA-2
  • GATA-3
  • IRF-1
  • Lmo2
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • RP58

Genomic Locations for OR2A5 Gene

Genomic Locations for OR2A5 Gene
chr7:144,048,948-144,058,845
(GRCh38/hg38)
Size:
9,898 bases
Orientation:
Plus strand
chr7:143,747,461-143,748,473
(GRCh37/hg19)
Size:
1,013 bases
Orientation:
Plus strand

Genomic View for OR2A5 Gene

Genes around OR2A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A5 Gene

Proteins for OR2A5 Gene

  • Protein details for OR2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R48-OR2A5_HUMAN
    Recommended name:
    Olfactory receptor 2A5
    Protein Accession:
    Q96R48
    Secondary Accessions:
    • B9EGX2
    • O43885
    • O43888

    Protein attributes for OR2A5 Gene

    Size:
    311 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A5 Gene

Post-translational modifications for OR2A5 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A5 Gene

Domains & Families for OR2A5 Gene

Gene Families for OR2A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A5 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR2A5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 2, subfamily A, member 5 (B9EGX1_HUMAN)
  • Olfactory receptor 7-138/7-141 (OR2A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96R48

UniProtKB/Swiss-Prot:

OR2A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A5: view

Function for OR2A5 Gene

Molecular function for OR2A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily A,member 5,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2A5 Gene

Gene Ontology (GO) - Molecular Function for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2A5: view
genes like me logo Genes that share phenotypes with OR2A5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A5 Gene

Localization for OR2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A5 Gene

Pathways & Interactions for OR2A5 Gene

genes like me logo Genes that share pathways with OR2A5: view

Pathways by source for OR2A5 Gene

1 BioSystems pathway for OR2A5 Gene
1 KEGG pathway for OR2A5 Gene

Interacting Proteins for OR2A5 Gene

;

Gene Ontology (GO) - Biological Process for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A5: view

No data available for SIGNOR curated interactions for OR2A5 Gene

Drugs & Compounds for OR2A5 Gene

No Compound Related Data Available

Transcripts for OR2A5 Gene

mRNA/cDNA for OR2A5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A5 Gene

No ASD Table

Relevant External Links for OR2A5 Gene

GeneLoc Exon Structure for
OR2A5

Expression for OR2A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2A5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2A5 Gene



Protein tissue co-expression partners for OR2A5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2A5

SOURCE GeneReport for Unigene cluster for OR2A5 Gene:

Hs.553793
genes like me logo Genes that share expression patterns with OR2A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A5 Gene

Orthologs for OR2A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR2A5 31
  • 99 (a)
OneToOne
LOC472572 30
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia OR2A5 31 30
  • 89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OR2A5 31 30
  • 88.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr812 30
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Or2a5 47 Olfr448 17 31 30
  • 83.66 (n)
Or13p8 47 Olfr1340
  • chr4:118,726,183-118,727,193
Or2a56 47 Olfr444
  • chr6:42,955,500-42,956,429
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
OneToMany
Species where no ortholog for OR2A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A5 Gene

ENSEMBL:
Gene Tree for OR2A5 (if available)
TreeFam:
Gene Tree for OR2A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR2A5: view image

Paralogs for OR2A5 Gene

(458) SIMAP similar genes for OR2A5 Gene using alignment to 2 proteins:

  • OR2A5_HUMAN
  • B9EGX1_HUMAN

Pseudogenes.org Pseudogenes for OR2A5 Gene

genes like me logo Genes that share paralogs with OR2A5: view

Variants for OR2A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2A5 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
784122 Benign: not provided 144,050,729(+) ACT/A FRAMESHIFT_VARIANT
rs2961144 - p.Ile126Val
rs6464573 - p.Ala202Ser
rs6464574 - p.Ala255Thr

Additional dbSNP identifiers (rs#s) for OR2A5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2A5 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv507424 OTHER sequence alteration 20534489
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608699 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897
nsv831174 CNV loss 17160897
nsv981598 CNV duplication 23825009

Variation tolerance for OR2A5 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.13; 98.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2A5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A5 Gene

Disorders for OR2A5 Gene

Additional Disease Information for OR2A5

No disorders were found for OR2A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A5 Gene

Publications for OR2A5 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 54
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 54
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 41 54

Products for OR2A5 Gene

Sources for OR2A5 Gene