Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2A5 Gene

Aliases for OR2A5 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 5 2 3 5
  • Olfactory Receptor 7-138/7-141 3 4
  • Olfactory Receptor 2A26 3 4
  • Olfactory Receptor 2A8 3 4
  • OR7-138 3 4
  • OR7-141 3 4
  • OR2A26 3 4
  • OR2A8 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 26 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 8 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 5 2
  • Olfactory Receptor 2A5 3
  • OR2A11P 3

External Ids for OR2A5 Gene

Previous HGNC Symbols for OR2A5 Gene

  • OR2A8
  • OR2A26

Previous GeneCards Identifiers for OR2A5 Gene

  • GC07U990161
  • GC07M141994
  • GC07P143207
  • GC07P143406
  • GC07Ph42714
  • GC07Ph43185
  • GC07P143378
  • GC07P143747
  • GC07P144050

Summaries for OR2A5 Gene

Entrez Gene Summary for OR2A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A5 Gene

OR2A5 (Olfactory Receptor Family 2 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A5 Gene

Additional gene information for OR2A5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A5 Gene

Genomics for OR2A5 Gene

GeneHancer (GH) Regulatory Elements for OR2A5 Gene

Promoters and enhancers for OR2A5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J144018 Enhancer 0.9 Ensembl ENCODE 11.6 -28.8 -28839 3.4 MEIS2 SOX13 JUN CEBPG BMI1 FOSL1 CTBP1 GATA3 POLR2A EGR1 ARHGEF35 OR2A5 OR2F1 LOC154761 OR6B1
GH07J143989 Enhancer 0.7 ENCODE 10.7 -59.5 -59525 0.2 MEIS2 PKNOX1 ATF1 TEAD4 TAL1 CHAMP1 TCF12 CTBP1 GATA2 NUFIP1 OR2F1 OR2A5 SLC16A1P1 OR6B1
GH07J143972 Enhancer 0.6 ENCODE 10.7 -74.8 -74832 2.3 ELF3 CEBPB ELF1 SP1 ZNF217 CTBP1 GATA3 JUND FOSL2 TCF7L2 OR6B1 OR2A5 LOC100422324 OR2F2 OR2F1
GH07J143929 Enhancer 0.5 ENCODE 9.8 -119.1 -119073 1 FOSL1 MCM3 PKNOX1 FOS BATF ARHGEF35 OR2A1 CASP2 OR2F1 TCAF1 LOC154761 OR2A5 OR2F2
GH07J144031 Enhancer 0.5 ENCODE 0.4 -17.2 -17205 1.3 NFIC NFIB ZSCAN4 NR2F2 ARHGEF35 OR2A25 OR2A41P OR2A5 OR6B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2A5 gene promoter:
  • Lmo2
  • IRF-1
  • GATA-3
  • GATA-2
  • GATA-1
  • RP58
  • AREB6
  • POU2F1c
  • POU2F1b
  • POU2F1a

Genomic Locations for OR2A5 Gene

Genomic Locations for OR2A5 Gene
9,898 bases
Plus strand
1,013 bases
Plus strand

Genomic View for OR2A5 Gene

Genes around OR2A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A5 Gene

Proteins for OR2A5 Gene

  • Protein details for OR2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2A5
    Protein Accession:
    Secondary Accessions:
    • B9EGX2
    • O43885
    • O43888

    Protein attributes for OR2A5 Gene

    311 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A5 Gene

Post-translational modifications for OR2A5 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A5 Gene

Domains & Families for OR2A5 Gene

Gene Families for OR2A5 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A5 Gene

Suggested Antigen Peptide Sequences for OR2A5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A5: view

Function for OR2A5 Gene

Molecular function for OR2A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily A,member 5,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR2A5 Gene

Gene Ontology (GO) - Molecular Function for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A5: view
genes like me logo Genes that share phenotypes with OR2A5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A5 Gene

Localization for OR2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A5 Gene

Pathways & Interactions for OR2A5 Gene

genes like me logo Genes that share pathways with OR2A5: view

Pathways by source for OR2A5 Gene

1 BioSystems pathway for OR2A5 Gene
1 KEGG pathway for OR2A5 Gene

Gene Ontology (GO) - Biological Process for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A5: view

No data available for SIGNOR curated interactions for OR2A5 Gene

Drugs & Compounds for OR2A5 Gene

No Compound Related Data Available

Transcripts for OR2A5 Gene

mRNA/cDNA for OR2A5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2A5 Gene

Olfactory receptor, family 2, subfamily A, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A5 Gene

No ASD Table

Relevant External Links for OR2A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2A5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2A5 Gene

Protein tissue co-expression partners for OR2A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2A5 Gene:


SOURCE GeneReport for Unigene cluster for OR2A5 Gene:

genes like me logo Genes that share expression patterns with OR2A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A5 Gene

Orthologs for OR2A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR2A5 34
  • 99 (a)
LOC472572 33
  • 98.82 (n)
(Canis familiaris)
Mammalia OR2A5 34 33
  • 89 (n)
(Bos Taurus)
Mammalia OR2A5 34 33
  • 88.42 (n)
(Rattus norvegicus)
Mammalia Olr812 33
  • 84.41 (n)
(Mus musculus)
Mammalia Or2a5 51 Olfr448 16 34 33
  • 83.66 (n)
Or13p8 51 Olfr1340
  • chr4:118,726,183-118,727,193
Or2a56 51 Olfr444
  • chr6:42,955,500-42,956,429
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
Species where no ortholog for OR2A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A5 Gene

Gene Tree for OR2A5 (if available)
Gene Tree for OR2A5 (if available)
Evolutionary constrained regions (ECRs) for OR2A5: view image

Paralogs for OR2A5 Gene

Paralogs for OR2A5 Gene

(458) SIMAP similar genes for OR2A5 Gene using alignment to 2 proteins:

  • B9EGX1_HUMAN Pseudogenes for OR2A5 Gene

genes like me logo Genes that share paralogs with OR2A5: view

Variants for OR2A5 Gene

Sequence variations from dbSNP and Humsavar for OR2A5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001506716 -- 144,051,484(+) A/G downstream_transcript_variant
rs1001843945 -- 144,050,022(+) C/T upstream_transcript_variant
rs1003046908 -- 144,049,728(+) T/C upstream_transcript_variant
rs1004431161 -- 144,049,887(+) G/A upstream_transcript_variant
rs1005485238 -- 144,051,501(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2A5 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv507424 OTHER sequence alteration 20534489
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608699 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897
nsv831174 CNV loss 17160897
nsv981598 CNV duplication 23825009

Variation tolerance for OR2A5 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.13; 98.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A5 Gene

Disorders for OR2A5 Gene

Additional Disease Information for OR2A5

No disorders were found for OR2A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A5 Gene

Publications for OR2A5 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OR2A5 Gene

Sources for OR2A5 Gene

Loading form....