Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2A42 Gene

Aliases for OR2A42 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 42 2 3 5
  • Olfactory Receptor 2A1/2A42 3 4
  • Olfactory Receptor OR7-16 3 4
  • Olfactory Receptor OR7-19 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 42 2
  • Olfactory Receptor, Family 2, Subfamily A, Member 1 3
  • OR2A42 5

External Ids for OR2A42 Gene

Previous GeneCards Identifiers for OR2A42 Gene

  • GC07M143320
  • GC07M143366
  • GC07M143559
  • GC07M143929

Summaries for OR2A42 Gene

Entrez Gene Summary for OR2A42 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A42 Gene

OR2A42 (Olfactory Receptor Family 2 Subfamily A Member 42) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A1.

UniProtKB/Swiss-Prot Summary for OR2A42 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2A42 Gene

Genomics for OR2A42 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2A42 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J144238 Enhancer 0.2 Ensembl 250.7 +0.9 904 0.6 OR2A42 piR-50443-350 ARHGEF35 ARHGEF35-AS1 OR2A1-AS1
GH07J144525 Enhancer 0.2 Ensembl 6.8 -286.6 -286596 0.8 OR2A42 MK280607-101 piR-48799-132 NOBOX HSALNG0062001-001 HSALNG0062001-002 TPK1
GH07J144256 Enhancer 0.7 Ensembl ENCODE 0.4 -16.6 -16599 1.2 NFE2 JUND MCM5 ETV1 MAFG ATF4 CEBPB ATF3 IKZF1 CEBPG OR2A20P CASP2 LOC154761 TCAF2 RN7SL535P OR2A9P CTAGE8 ARHGEF35 OR2A7 OR2A42
GH07J144242 Enhancer 0.2 Ensembl 0.7 -3.8 -3796 0.8 OR2A42 OR2A20P OR2A7 ARHGEF35-AS1 OR2A1-AS1
GH07J144235 Enhancer 0.2 Ensembl 0.7 +3.3 3263 1.9 OR2A42 piR-50443-350 ARHGEF35 ARHGEF35-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2A42 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2A42

Top Transcription factor binding sites by QIAGEN in the OR2A42 gene promoter:
  • c-Myc
  • deltaCREB
  • E47
  • GATA-1
  • Max
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for OR2A42 Gene

Latest Assembly
chr7:144,228,244-144,239,605
(GRCh38/hg38)
Size:
11,362 bases
Orientation:
Minus strand

Previous Assembly
chr7:143,925,337-143,936,698
(GRCh37/hg19 by Entrez Gene)
Size:
11,362 bases
Orientation:
Minus strand

chr7:143,929,004-143,929,936
(GRCh37/hg19 by Ensembl)
Size:
933 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr7(PATCHES):182,841-194,199 (-)

Genomic View for OR2A42 Gene

Genes around OR2A42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A42 Gene

Proteins for OR2A42 Gene

  • Protein details for OR2A42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT9-OR2A1_HUMAN
    Recommended name:
    Olfactory receptor 2A1/2A42
    Protein Accession:
    Q8NGT9
    Secondary Accessions:
    • Q6IF44
    • Q96R46

    Protein attributes for OR2A42 Gene

    Size:
    310 amino acids
    Molecular mass:
    34714 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05915.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2A42 Gene

Post-translational modifications for OR2A42 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A42 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A42 Gene

Domains & Families for OR2A42 Gene

Gene Families for OR2A42 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A42 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2A42 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR7-19 (OR2A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGT9

UniProtKB/Swiss-Prot:

OR2A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A42: view

Function for OR2A42 Gene

Molecular function for OR2A42 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2A42: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2A42

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A42 Gene

Localization for OR2A42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A42 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A42 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for OR2A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2A42: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A42 Gene

Pathways & Interactions for OR2A42 Gene

genes like me logo Genes that share pathways with OR2A42: view

Pathways by source for OR2A42 Gene

Interacting Proteins for OR2A42 Gene

Gene Ontology (GO) - Biological Process for OR2A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A42: view

No data available for SIGNOR curated interactions for OR2A42 Gene

Drugs & Compounds for OR2A42 Gene

No Compound Related Data Available

Transcripts for OR2A42 Gene

mRNA/cDNA for OR2A42 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2A42

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A42 Gene

No ASD Table

Relevant External Links for OR2A42 Gene

GeneLoc Exon Structure for
OR2A42

Expression for OR2A42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2A42 Gene

mRNA differential expression in normal tissues according to GTEx for OR2A42 Gene

This gene is overexpressed in Thyroid (x7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2A42 Gene



Protein tissue co-expression partners for OR2A42 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2A42

genes like me logo Genes that share expression patterns with OR2A42: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A42 Gene

Orthologs for OR2A42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A42 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC744895 29
  • 98.17 (n)
-- 30
  • 97 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia OR08A11 29 30
  • 85.48 (n)
ManyToMany
-- 30
  • 80 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC504233 29
  • 84.14 (n)
-- 30
  • 47 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr435 29 16 30
  • 79.46 (n)
ManyToMany
Olfr434 30
  • 77 (a)
ManyToMany
Olfr47 30
  • 76 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr819 29
  • 77.53 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 51 (a)
ManyToMany
Species where no ortholog for OR2A42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2A42 Gene

ENSEMBL:
Gene Tree for OR2A42 (if available)
TreeFam:
Gene Tree for OR2A42 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR2A42

Paralogs for OR2A42 Gene

(455) SIMAP similar genes for OR2A42 Gene using alignment to 1 proteins:

  • OR2A1_HUMAN

Pseudogenes.org Pseudogenes for OR2A42 Gene

genes like me logo Genes that share paralogs with OR2A42: view

Variants for OR2A42 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2A42 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2A42 Gene

Variant ID Type Subtype PubMed ID
dgv11668n54 CNV gain 21841781
dgv11669n54 CNV loss 21841781
dgv11679n54 CNV loss 21841781
dgv11684n54 CNV loss 21841781
dgv11685n54 CNV loss 21841781
dgv11686n54 CNV loss 21841781
dgv152e203 CNV gain+loss 21179565
dgv24n31 CNV gain 19718026
dgv253n111 CNV duplication 26073780
dgv254n111 CNV duplication 26073780
dgv255n111 CNV deletion 26073780
dgv3972e59 CNV duplication 20981092
dgv3976e59 CNV duplication 20981092
dgv6726n100 CNV gain 25217958
dgv6727n100 CNV loss 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6729n100 CNV gain 25217958
dgv6730n100 CNV loss 25217958
dgv6731n100 CNV gain+loss 25217958
dgv6732n100 CNV gain+loss 25217958
dgv6733n100 CNV gain+loss 25217958
dgv6734n100 CNV gain+loss 25217958
dgv6735n100 CNV gain 25217958
dgv6736n100 CNV gain 25217958
dgv6737n100 CNV gain 25217958
dgv6738n100 CNV gain+loss 25217958
dgv6739n100 CNV gain+loss 25217958
dgv6740n100 CNV loss 25217958
dgv6741n100 CNV loss 25217958
dgv6742n100 CNV loss 25217958
dgv6743n100 CNV gain+loss 25217958
dgv6744n100 CNV loss 25217958
dgv6745n100 CNV loss 25217958
esv1003295 OTHER inversion 20482838
esv1682998 OTHER inversion 17803354
esv24292 CNV gain+loss 19812545
esv2759570 CNV gain+loss 17122850
esv33253 CNV gain 17666407
esv3380478 CNV duplication 20981092
esv3392001 CNV duplication 20981092
esv3432947 CNV duplication 20981092
esv3433980 CNV duplication 20981092
esv3584873 CNV loss 24956385
esv3891225 CNV gain 25118596
nsv1016831 CNV gain 25217958
nsv1141559 CNV duplication 24896259
nsv1148453 CNV duplication 26484159
nsv1149323 CNV duplication 26484159
nsv428188 CNV gain+loss 18775914
nsv433394 CNV gain 18776910
nsv469769 CNV gain+loss 16826518
nsv471455 CNV gain 19718026
nsv471646 CNV gain+loss 15918152
nsv508489 CNV deletion 20534489
nsv515040 CNV gain 21397061
nsv608699 CNV gain 21841781
nsv608764 CNV loss 21841781
nsv608831 CNV loss 21841781
nsv608857 CNV gain 21841781
nsv7411 OTHER inversion 18451855
nsv819701 CNV insertion 19587683
nsv821609 CNV duplication 20802225
nsv8227 CNV gain+loss 18304495
nsv824360 CNV gain 20364138
nsv831175 CNV loss 17160897
nsv970597 CNV duplication 23825009
nsv970599 CNV duplication 23825009
nsv981600 CNV duplication 23825009

Variation tolerance for OR2A42 Gene

Gene Damage Index Score: 2.72; 46.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2A42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2A42
Leiden Open Variation Database (LOVD)
OR2A42

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2A42 Gene

Disorders for OR2A42 Gene

Additional Disease Information for OR2A42

No disorders were found for OR2A42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A42 Gene

Publications for OR2A42 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2A42 Gene

Sources for OR2A42 Gene