Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR2A4 Gene

Aliases for OR2A4 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 2, Subfamily A, Member 10 2 3
  • Olfactory Receptor OR6-37 3 4
  • Olfactory Receptor 2A10 3 4
  • Olfactory Receptor 2A4 3 4
  • OR2A10 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 4 2
  • OR2A4 5

External Ids for OR2A4 Gene

Previous HGNC Symbols for OR2A4 Gene

  • OR2A10

Previous GeneCards Identifiers for OR2A4 Gene

  • GC07M142202
  • GC06M131868
  • GC06M132002
  • GC06M132063
  • GC06M132021
  • GC07M143295

Summaries for OR2A4 Gene

Entrez Gene Summary for OR2A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A4 Gene

OR2A4 (Olfactory Receptor Family 2 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is OR2A7.

UniProtKB/Swiss-Prot Summary for OR2A4 Gene

Gene Wiki entry for OR2A4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR2A4 Gene

Genomics for OR2A4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR2A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J131727 Enhancer 0.5 dbSUPER 6.7 -27.7 -27736 2.5 CEBPA BCL6 CEBPB HLF KDM1A RXRA ENPP3 OR2A4 CTAGE9 HSALNG0053506 ENPP1
GH06J131732 Enhancer 0.7 Ensembl ENCODE dbSUPER 4.7 -32.3 -32300 1.8 EGR2 ZFHX2 OR2A4 HSALNG0053506 CTAGE9 ENPP1 ENPP3
GH06J131693 Enhancer 0.4 Ensembl 7.8 +7.6 7600 0.4 FOXA2 HLF NANOG OR2A4 ENPP3 HSALNG0053503 RNU4-18P
GH06J131723 Enhancer 0.2 Ensembl 5.2 -22.8 -22800 0.4 OR2A4 CTAGE9 HSALNG0053506 ENPP1 ENPP3
GH06J131634 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 0.2 +64.6 64570 4.5 SSRP1 ZMYM3 KLF9 CEBPA YY1 KLF11 SMAD5 TBP HOMEZ KMT2B HSALNG0053502 ENPP3 ARG1 OR2A4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2A4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR2A4

Top Transcription factor binding sites by QIAGEN in the OR2A4 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • NCX
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • PPAR-alpha

Genomic Locations for OR2A4 Gene

Latest Assembly
chr6:131,699,644-131,701,401
(GRCh38/hg38)
Size:
1,758 bases
Orientation:
Minus strand

Previous Assembly
chr6:132,020,784-132,022,541
(GRCh37/hg19 by Entrez Gene)
Size:
1,758 bases
Orientation:
Minus strand

chr6:132,021,520-132,022,635
(GRCh37/hg19 by Ensembl)
Size:
1,116 bases
Orientation:
Minus strand

Genomic View for OR2A4 Gene

Genes around OR2A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A4 Gene

Proteins for OR2A4 Gene

  • Protein details for OR2A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95047-OR2A4_HUMAN
    Recommended name:
    Olfactory receptor 2A4
    Protein Accession:
    O95047
    Secondary Accessions:
    • Q0VAR3
    • Q6IF18
    • Q9NQN0

    Protein attributes for OR2A4 Gene

    Size:
    310 amino acids
    Molecular mass:
    34802 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB99212.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2A4 Gene

Post-translational modifications for OR2A4 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A4 Gene

Domains & Families for OR2A4 Gene

Gene Families for OR2A4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR2A4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR6-37 (OR2A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95047

UniProtKB/Swiss-Prot:

OR2A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A4: view

Function for OR2A4 Gene

Molecular function for OR2A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2A4 Gene

Gene Ontology (GO) - Molecular Function for OR2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR2A4: view
genes like me logo Genes that share phenotypes with OR2A4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2A4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2A4 Gene

Localization for OR2A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
endosome 5

Gene Ontology (GO) - Cellular Components for OR2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
GO:0032154 cleavage furrow IDA 22888021
GO:0055037 recycling endosome IDA 22888021
genes like me logo Genes that share ontologies with OR2A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A4 Gene

Pathways & Interactions for OR2A4 Gene

genes like me logo Genes that share pathways with OR2A4: view

Pathways by source for OR2A4 Gene

1 KEGG pathway for OR2A4 Gene

Interacting Proteins for OR2A4 Gene

Gene Ontology (GO) - Biological Process for OR2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0032956 regulation of actin cytoskeleton organization IMP 22888021
genes like me logo Genes that share ontologies with OR2A4: view

No data available for SIGNOR curated interactions for OR2A4 Gene

Drugs & Compounds for OR2A4 Gene

No Compound Related Data Available

Transcripts for OR2A4 Gene

mRNA/cDNA for OR2A4 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2A4

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A4 Gene

No ASD Table

Relevant External Links for OR2A4 Gene

GeneLoc Exon Structure for
OR2A4

Expression for OR2A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2A4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR2A4

SOURCE GeneReport for Unigene cluster for OR2A4 Gene:

Hs.734368
genes like me logo Genes that share expression patterns with OR2A4: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A4 Gene

Orthologs for OR2A4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A4 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LOC608585 29
  • 86.88 (n)
-- 30
  • 84 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC507423 29
  • 84.47 (n)
-- 30
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr13 29 30
  • 80.43 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr818 29
  • 80.32 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 64 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 42 (a)
ManyToMany
Species where no ortholog for OR2A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR2A4 Gene

ENSEMBL:
Gene Tree for OR2A4 (if available)
TreeFam:
Gene Tree for OR2A4 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR2A4

Paralogs for OR2A4 Gene

(448) SIMAP similar genes for OR2A4 Gene using alignment to 1 proteins:

  • OR2A4_HUMAN
genes like me logo Genes that share paralogs with OR2A4: view

Variants for OR2A4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR2A4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR2A4 Gene

Variant ID Type Subtype PubMed ID
dgv3658e59 CNV duplication 20981092
dgv88n68 CNV loss 17160897
esv24430 CNV gain+loss 19812545
esv3377992 CNV duplication 20981092
esv3384854 CNV duplication 20981092
nsv1139874 CNV duplication 24896259
nsv1153899 CNV duplication 26484159
nsv471444 CNV gain 19718026
nsv7968 CNV loss 18304495
nsv821228 CNV duplication 20802225
nsv981184 CNV duplication 23825009

Variation tolerance for OR2A4 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2A4
Leiden Open Variation Database (LOVD)
OR2A4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR2A4 Gene

Disorders for OR2A4 Gene

Additional Disease Information for OR2A4

No disorders were found for OR2A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A4 Gene

Publications for OR2A4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  4. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. (PMID: 27315375) Tsai T … Hatt H (Experimental dermatology 2017) 3
  5. G protein-coupled receptors participate in cytokinesis. (PMID: 22888021) Zhang X … Eggert US (Cytoskeleton (Hoboken, N.J.) 2012) 3

Products for OR2A4 Gene

Sources for OR2A4 Gene