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Aliases for OR2A1 Gene

Aliases for OR2A1 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR7-16 3 4
  • Olfactory Receptor OR7-19 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 1 2
  • Olfactory Receptor 2A1/2A42 3

External Ids for OR2A1 Gene

Previous GeneCards Identifiers for OR2A1 Gene

  • GC07U990174
  • GC07P143407
  • GC07P143452
  • GC07P143646
  • GC07P144015

Summaries for OR2A1 Gene

Entrez Gene Summary for OR2A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A1 Gene

OR2A1 (Olfactory Receptor Family 2 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A1 Gene

Additional gene information for OR2A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A1 Gene

Genomics for OR2A1 Gene

GeneHancer (GH) Regulatory Elements for OR2A1 Gene

Promoters and enhancers for OR2A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143378 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.9 -925.8 -925752 15.9 MLX YBX1 YY1 ZNF213 ZNF143 SP3 MEF2D GLIS1 RCOR2 NR2C1 ZYX FAM131B CASP2 LOC154761 OR2A1 RN7SL535P EPHA1-AS1 EPHA1 TCAF2 HINT1P1
GH07J144833 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +523.6 523584 3.2 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN KDM1A TPK1 CTAGE8 LOC154761 OR2A1 GC07M144690
GH07J143396 Enhancer 0.8 ENCODE dbSUPER 12.5 -916.6 -916583 0.2 CTCF MCM3 ZNF792 KMT2B ZNF48 RBPJ ZGPAT POLR2A IKZF5 SPI1 OR2A1 CASP2 LOC154761 EPHA1 MIR6892 EPHA1-AS1
GH07J143405 Enhancer 0.6 ENCODE 12.5 -905.7 -905706 2.2 MCM3 MCM5 CBFA2T3 ZBTB5 TCF12 SP1 MCM7 POLR2A IKZF1 CBFA2T2 EPHA1-AS1 CASP2 LOC154761 OR2A1 TCAF2 RN7SL535P EPHA1 MIR6892
GH07J143929 Enhancer 0.5 ENCODE 12.5 -382.1 -382071 1 FOSL1 MCM3 PKNOX1 FOS BATF ARHGEF35 OR2A1 CASP2 OR2F1 TCAF1 LOC154761 OR2A5 OR2F2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2A1 gene promoter:
  • Max
  • c-Myc
  • GATA-1
  • E47
  • deltaCREB
  • CREB
  • Tal-1
  • Pbx1a

Genomic Locations for OR2A1 Gene

Genomic Locations for OR2A1 Gene
10,723 bases
Plus strand
933 bases
Plus strand

Genomic View for OR2A1 Gene

Genes around OR2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A1 Gene

Proteins for OR2A1 Gene

  • Protein details for OR2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2A1/2A42
    Protein Accession:
    Secondary Accessions:
    • Q6IF44
    • Q96R46
    • Q6IF44
    • Q96R46

    Protein attributes for OR2A1 Gene

    310 amino acids
    Molecular mass:
    34714 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05915.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    • Sequence=BAC05915.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2A1 Gene

Post-translational modifications for OR2A1 Gene

  • Glycosylation at isoforms=4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A1 Gene

Domains & Families for OR2A1 Gene

Gene Families for OR2A1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A1: view

No data available for Suggested Antigen Peptide Sequences for OR2A1 Gene

Function for OR2A1 Gene

Molecular function for OR2A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2A1 Gene

Gene Ontology (GO) - Molecular Function for OR2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A1: view

Phenotypes for OR2A1 Gene

genes like me logo Genes that share phenotypes with OR2A1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A1 Gene

Localization for OR2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A1 Gene

Pathways & Interactions for OR2A1 Gene

genes like me logo Genes that share pathways with OR2A1: view

Pathways by source for OR2A1 Gene

Interacting Proteins for OR2A1 Gene

Gene Ontology (GO) - Biological Process for OR2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A1: view

No data available for SIGNOR curated interactions for OR2A1 Gene

Drugs & Compounds for OR2A1 Gene

No Compound Related Data Available

Transcripts for OR2A1 Gene

mRNA/cDNA for OR2A1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2A1 Gene

Olfactory receptor, family 2, subfamily A, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A1 Gene

No ASD Table

Relevant External Links for OR2A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2A1 Gene

This gene is overexpressed in Thyroid (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2A1 Gene

Protein tissue co-expression partners for OR2A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OR2A1 Gene:


SOURCE GeneReport for Unigene cluster for OR2A1 Gene:

genes like me logo Genes that share expression patterns with OR2A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A1 Gene

Orthologs for OR2A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC744895 33
  • 98.28 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia OR08A11 34 33
  • 85.59 (n)
-- 34
  • 80 (a)
(Bos Taurus)
Mammalia LOC504233 33
  • 84.25 (n)
-- 34
  • 47 (a)
(Mus musculus)
Mammalia Or2a51 51 Olfr435 34 33
  • 79.46 (n)
Olfr434 34
  • 77 (a)
Olfr47 34
  • 76 (a)
Or13p10 51 Olfr62
  • chr4:118,665,333-118,666,463
Or13p4 51 Olfr1342
  • chr4:118,689,506-118,690,450
(Rattus norvegicus)
Mammalia Olr819 33
  • 77.63 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
Species where no ortholog for OR2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A1 Gene

Gene Tree for OR2A1 (if available)
Gene Tree for OR2A1 (if available)

Paralogs for OR2A1 Gene

Paralogs for OR2A1 Gene

(460) SIMAP similar genes for OR2A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OR2A1: view

Variants for OR2A1 Gene

Sequence variations from dbSNP and Humsavar for OR2A1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000371935 -- 144,317,847(+) G/A upstream_transcript_variant
rs1004745404 -- 144,316,540(+) T/C upstream_transcript_variant
rs1020602008 -- 144,319,402(+) A/G downstream_transcript_variant
rs1028597648 -- 144,317,565(+) A/G upstream_transcript_variant
rs1037026965 -- 144,317,233(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2A1 Gene

Variant ID Type Subtype PubMed ID
dgv11668n54 CNV gain 21841781
dgv11669n54 CNV loss 21841781
dgv11679n54 CNV loss 21841781
dgv11684n54 CNV loss 21841781
dgv11685n54 CNV loss 21841781
dgv11686n54 CNV loss 21841781
dgv152e203 CNV gain+loss 21179565
dgv24n31 CNV gain 19718026
dgv253n111 CNV duplication 26073780
dgv254n111 CNV duplication 26073780
dgv255n111 CNV deletion 26073780
dgv3972e59 CNV duplication 20981092
dgv3976e59 CNV duplication 20981092
dgv6726n100 CNV gain 25217958
dgv6727n100 CNV loss 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6729n100 CNV gain 25217958
dgv6730n100 CNV loss 25217958
dgv6731n100 CNV gain+loss 25217958
dgv6732n100 CNV gain+loss 25217958
dgv6733n100 CNV gain+loss 25217958
dgv6734n100 CNV gain+loss 25217958
dgv6735n100 CNV gain 25217958
dgv6736n100 CNV gain 25217958
dgv6737n100 CNV gain 25217958
dgv6738n100 CNV gain+loss 25217958
dgv6739n100 CNV gain+loss 25217958
dgv6740n100 CNV loss 25217958
dgv6741n100 CNV loss 25217958
dgv6742n100 CNV loss 25217958
dgv6743n100 CNV gain+loss 25217958
dgv6744n100 CNV loss 25217958
dgv6745n100 CNV loss 25217958
esv1003295 OTHER inversion 20482838
esv1682998 OTHER inversion 17803354
esv24292 CNV gain+loss 19812545
esv2759570 CNV gain+loss 17122850
esv33253 CNV gain 17666407
esv3380478 CNV duplication 20981092
esv3392001 CNV duplication 20981092
esv3432947 CNV duplication 20981092
esv3433980 CNV duplication 20981092
esv3584873 CNV loss 24956385
esv3891225 CNV gain 25118596
nsv1016831 CNV gain 25217958
nsv1141559 CNV duplication 24896259
nsv1148453 CNV duplication 26484159
nsv1149323 CNV duplication 26484159
nsv428188 CNV gain+loss 18775914
nsv433394 CNV gain 18776910
nsv469769 CNV gain+loss 16826518
nsv471455 CNV gain 19718026
nsv471646 CNV gain+loss 15918152
nsv508489 CNV deletion 20534489
nsv515040 CNV gain 21397061
nsv608699 CNV gain 21841781
nsv608764 CNV loss 21841781
nsv608831 CNV loss 21841781
nsv608857 CNV gain 21841781
nsv7411 OTHER inversion 18451855
nsv819701 CNV insertion 19587683
nsv821609 CNV duplication 20802225
nsv8227 CNV gain+loss 18304495
nsv824360 CNV gain 20364138
nsv831175 CNV loss 17160897
nsv970597 CNV duplication 23825009
nsv970599 CNV duplication 23825009
nsv981600 CNV duplication 23825009

Variation tolerance for OR2A1 Gene

Gene Damage Index Score: 3.01; 50.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A1 Gene

Disorders for OR2A1 Gene

Additional Disease Information for OR2A1

No disorders were found for OR2A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A1 Gene

Publications for OR2A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR2A1 Gene

Sources for OR2A1 Gene

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