Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1S2 Gene

Aliases for OR1S2 Gene

  • Olfactory Receptor Family 1 Subfamily S Member 2 2 3 5
  • Olfactory Receptor OR11-231 3 4
  • Olfactory Receptor 1S2 3 4
  • Olfactory Receptor, Family 1, Subfamily S, Member 2 2
  • OR11-231 3
  • OR1S2 5

External Ids for OR1S2 Gene

Previous GeneCards Identifiers for OR1S2 Gene

  • GC11U990572
  • GC11M057748
  • GC11M057727
  • GC11M057970

Summaries for OR1S2 Gene

Entrez Gene Summary for OR1S2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1S2 Gene

OR1S2 (Olfactory Receptor Family 1 Subfamily S Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1S1.

UniProtKB/Swiss-Prot Summary for OR1S2 Gene

Gene Wiki entry for OR1S2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1S2 Gene

Genomics for OR1S2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1S2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J058164 Enhancer 0.8 ENCODE 11.5 +38.9 38862 2 CEBPA CHD4 THAP11 FOXA2 KDM6A SMAD4 SAP130 ETV4 MIER3 RARA HSALNG0084335 OR9Q2 OR1S2 OR10W1 RNU6-899P OR9Q1 MED19 TIMM10 OR5BL1P OR9I1
GH11J058316 Enhancer 0.5 Ensembl 10.6 -112.1 -112120 0.6 MAFK ZNF24 JUND NFE2L2 SPI1 FOS OR10W1 OR1S2 OR5B2 lnc-OR5B17-2 piR-31922-003 OR5B17
GH11J058163 Enhancer 0.2 Ensembl 11.5 +40.4 40380 0.4 HSALNG0084335 OR1S2 OR9Q2 OR10W1 OR9Q1 RNU6-899P OR9I2P OR9I1
GH11J057946 Enhancer 0.2 FANTOM5 2.4 +257.7 257747 0 OR5BD1P piR-38352-080 lnc-OR9I1-4 piR-50308-086 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12
GH11J058632 Enhancer 0.2 FANTOM5 2.1 -428.1 -428060 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 HSALNG0084356
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1S2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1S2

Top Transcription factor binding sites by QIAGEN in the OR1S2 gene promoter:
  • AP-1
  • ATF
  • c-Fos
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • Sox9

Genomic Locations for OR1S2 Gene

Latest Assembly
chr11:58,203,202-58,204,181
(GRCh38/hg38)
Size:
980 bases
Orientation:
Minus strand

Previous Assembly
chr11:57,970,676-57,971,653
(GRCh37/hg19 by Entrez Gene)
Size:
978 bases
Orientation:
Minus strand

chr11:57,970,674-57,971,653
(GRCh37/hg19 by Ensembl)
Size:
980 bases
Orientation:
Minus strand

Genomic View for OR1S2 Gene

Genes around OR1S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1S2 Gene

Proteins for OR1S2 Gene

  • Protein details for OR1S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGQ3-OR1S2_HUMAN
    Recommended name:
    Olfactory receptor 1S2
    Protein Accession:
    Q8NGQ3
    Secondary Accessions:
    • Q6IFG5
    • Q96R85

    Protein attributes for OR1S2 Gene

    Size:
    325 amino acids
    Molecular mass:
    36579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05957.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1S2 Gene

Post-translational modifications for OR1S2 Gene

  • Glycosylation at Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1S2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1S2 Gene

Domains & Families for OR1S2 Gene

Gene Families for OR1S2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1S2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1S2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-231 (OR1S2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGQ3

UniProtKB/Swiss-Prot:

OR1S2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1S2: view

Function for OR1S2 Gene

Molecular function for OR1S2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR1S2 Gene

Gene Ontology (GO) - Molecular Function for OR1S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1S2: view
genes like me logo Genes that share phenotypes with OR1S2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1S2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1S2 Gene

Localization for OR1S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1S2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1S2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1S2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1S2 Gene

Pathways & Interactions for OR1S2 Gene

genes like me logo Genes that share pathways with OR1S2: view

Pathways by source for OR1S2 Gene

Interacting Proteins for OR1S2 Gene

Gene Ontology (GO) - Biological Process for OR1S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1S2: view

No data available for SIGNOR curated interactions for OR1S2 Gene

Drugs & Compounds for OR1S2 Gene

No Compound Related Data Available

Transcripts for OR1S2 Gene

mRNA/cDNA for OR1S2 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1S2

Alternative Splicing Database (ASD) splice patterns (SP) for OR1S2 Gene

No ASD Table

Relevant External Links for OR1S2 Gene

GeneLoc Exon Structure for
OR1S2

Expression for OR1S2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1S2 Gene

Protein differential expression in normal tissues from HIPED for OR1S2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR1S2 Gene



Protein tissue co-expression partners for OR1S2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1S2

SOURCE GeneReport for Unigene cluster for OR1S2 Gene:

Hs.553644
genes like me logo Genes that share expression patterns with OR1S2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1S2 Gene

Orthologs for OR1S2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1S2 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Or1s2 45 Olfr1496 30
  • 79 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 73 (a)
ManyToMany
-- 30
  • 72 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 54 (a)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 49 (a)
ManyToMany
Species where no ortholog for OR1S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1S2 Gene

ENSEMBL:
Gene Tree for OR1S2 (if available)
TreeFam:
Gene Tree for OR1S2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1S2: view image
Alliance of Genome Resources:
Additional Orthologs for OR1S2

Paralogs for OR1S2 Gene

(452) SIMAP similar genes for OR1S2 Gene using alignment to 1 proteins:

  • OR1S2_HUMAN
genes like me logo Genes that share paralogs with OR1S2: view

Variants for OR1S2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1S2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs193921006 Uncertain Significance: Malignant tumor of prostate 58,203,680(-) T/C
NM_001004459.1(OR1S2):c.502A>G (p.Ile168Val)
MISSENSE
rs11229277 -- p.Val225Ala
rs11229278 -- p.Val225Ile
rs11229281 -- p.Ile59Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1S2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1S2 Gene

Variant ID Type Subtype PubMed ID
dgv222n67 CNV loss 20364138
nsv825916 CNV gain 20364138
nsv832165 CNV gain 17160897
nsv832166 CNV gain+loss 17160897
nsv972033 CNV duplication 23825009

Variation tolerance for OR1S2 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1S2 Gene

Human Gene Mutation Database (HGMD)
OR1S2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1S2
Leiden Open Variation Database (LOVD)
OR1S2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1S2 Gene

Disorders for OR1S2 Gene

Additional Disease Information for OR1S2

No disorders were found for OR1S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1S2 Gene

Publications for OR1S2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR1S2 Gene

Sources for OR1S2 Gene