Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1Q1 Gene

Aliases for OR1Q1 Gene

  • Olfactory Receptor Family 1 Subfamily Q Member 1 2 3 5
  • OST226 2 3 4
  • OR9-A 2 3 4
  • Olfactory Receptor TPCR106 3 4
  • Olfactory Receptor OR9-25 3 4
  • Olfactory Receptor 1Q1 3 4
  • Olfactory Receptor 1Q2 3 4
  • Olfactory Receptor 1Q3 3 4
  • Olfactory Receptor 9-A 3 4
  • OST226OR9-A 2 3
  • HSTPCR106 2 3
  • TPCR106 2 3
  • OR1Q2 3 4
  • OR1Q3 3 4
  • Olfactory Receptor, Family 1, Subfamily Q, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily Q, Member 2 3
  • Olfactory Receptor, Family 1, Subfamily Q, Member 3 3
  • OR9-25 3
  • OR1Q1 5

External Ids for OR1Q1 Gene

Previous HGNC Symbols for OR1Q1 Gene

  • OR1Q2
  • OR1Q3

Previous GeneCards Identifiers for OR1Q1 Gene

  • GC09U990112
  • GC09M117023
  • GC09P118830
  • GC09P120753
  • GC09P120749
  • GC09P122456
  • GC09P124416
  • GC09P125376
  • GC09P122568

Summaries for OR1Q1 Gene

Entrez Gene Summary for OR1Q1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1Q1 Gene

OR1Q1 (Olfactory Receptor Family 1 Subfamily Q Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L6.

UniProtKB/Swiss-Prot Summary for OR1Q1 Gene

Gene Wiki entry for OR1Q1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1Q1 Gene

Genomics for OR1Q1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1Q1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122355 Enhancer 0.7 FANTOM5 Ensembl 49.1 -259.2 -259237 3 CTCF ZNF652 RAD21 ZNF143 IKZF1 ZNF444 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 ENSG00000233616
GH09J122464 Enhancer 0.8 ENCODE 15.8 -149.7 -149706 1.4 ZNF654 BRCA1 YY1 CTCF REST ZNF592 DEK TRIM22 IRF2 RAD21 OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 MRRF RBM18 TTLL11 piR-48369-212
GH09J122389 Enhancer 0.8 Ensembl ENCODE 9.6 -222.6 -222638 7.4 JUND CEBPB BHLHE40 SPI1 PKNOX1 ATF4 ARID1B IKZF1 ATF3 EP300 PTGS1 ENSG00000234156 OR1K1 OR1Q1 OR1N2 ENSG00000233616 lnc-OR1J1-2 OR1J2
GH09J122468 Enhancer 0.2 ENCODE 26.8 -145.9 -145891 1.5 piR-48369-212 OR1Q1 OR1J4 OR1K1 OR5C1 OR1J1 HSALNG0074242 OR1J2 ENSG00000234156
GH09J122766 Enhancer 0.2 FANTOM5 10.5 +152.3 152267 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1Q1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1Q1

Top Transcription factor binding sites by QIAGEN in the OR1Q1 gene promoter:
  • AML1a
  • COMP1
  • CREB
  • deltaCREB
  • E47
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Tal-1

Genomic Locations for OR1Q1 Gene

Latest Assembly
chr9:122,614,738-122,615,682
(GRCh38/hg38)
Size:
945 bases
Orientation:
Plus strand

Previous Assembly
chr9:125,377,017-125,377,961
(GRCh37/hg19 by Entrez Gene)
Size:
945 bases
Orientation:
Plus strand

chr9:125,376,948-125,378,026
(GRCh37/hg19 by Ensembl)
Size:
1,079 bases
Orientation:
Plus strand

Genomic View for OR1Q1 Gene

Genes around OR1Q1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1Q1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1Q1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1Q1 Gene

Proteins for OR1Q1 Gene

  • Protein details for OR1Q1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15612-OR1Q1_HUMAN
    Recommended name:
    Olfactory receptor 1Q1
    Protein Accession:
    Q15612
    Secondary Accessions:
    • Q6IFN4
    • Q8NGR7
    • Q96R82

    Protein attributes for OR1Q1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1Q1 Gene

Post-translational modifications for OR1Q1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1Q1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1Q1 Gene

Domains & Families for OR1Q1 Gene

Gene Families for OR1Q1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1Q1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1Q1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 1, subfamily Q, member 1 (B9EIK1_HUMAN)
  • Olfactory receptor TPCR106 (OR1Q1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15612

UniProtKB/Swiss-Prot:

OR1Q1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1Q1: view

Function for OR1Q1 Gene

Molecular function for OR1Q1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR1Q1 Gene

Gene Ontology (GO) - Molecular Function for OR1Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR1Q1: view
genes like me logo Genes that share phenotypes with OR1Q1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1Q1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1Q1 Gene

Localization for OR1Q1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1Q1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1Q1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR1Q1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1Q1 Gene

Pathways & Interactions for OR1Q1 Gene

genes like me logo Genes that share pathways with OR1Q1: view

Pathways by source for OR1Q1 Gene

1 KEGG pathway for OR1Q1 Gene

Interacting Proteins for OR1Q1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000297913 Q15612-OR1Q1_HUMAN for OR1Q1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR1Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1Q1: view

No data available for SIGNOR curated interactions for OR1Q1 Gene

Drugs & Compounds for OR1Q1 Gene

No Compound Related Data Available

Transcripts for OR1Q1 Gene

mRNA/cDNA for OR1Q1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1Q1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1Q1 Gene

No ASD Table

Relevant External Links for OR1Q1 Gene

GeneLoc Exon Structure for
OR1Q1

Expression for OR1Q1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1Q1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1Q1 Gene

This gene is overexpressed in Bladder (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1Q1

SOURCE GeneReport for Unigene cluster for OR1Q1 Gene:

Hs.684864
genes like me logo Genes that share expression patterns with OR1Q1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1Q1 Gene

Orthologs for OR1Q1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1Q1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC736157 29
  • 99.68 (n)
OR1Q1 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR1Q1 29 30
  • 84.29 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or1q1 45 Olfr357 29 16 30
  • 82.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr420 29
  • 80.74 (n)
Oppossum
(Monodelphis domestica)
Mammalia OPOR54 30
  • 68 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 40 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 49 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
Species where no ortholog for OR1Q1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1Q1 Gene

ENSEMBL:
Gene Tree for OR1Q1 (if available)
TreeFam:
Gene Tree for OR1Q1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1Q1: view image
Alliance of Genome Resources:
Additional Orthologs for OR1Q1

Paralogs for OR1Q1 Gene

(458) SIMAP similar genes for OR1Q1 Gene using alignment to 2 proteins:

  • OR1Q1_HUMAN
  • B9EIK1_HUMAN
genes like me logo Genes that share paralogs with OR1Q1: view

Variants for OR1Q1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1Q1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1329957 -- p.Ile163Met
rs727913 -- p.Thr240Ala
rs972925 -- p.Gln24Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1Q1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1Q1 Gene

Variant ID Type Subtype PubMed ID
nsv1039785 CNV gain 25217958
nsv1054800 CNV loss 25217958
nsv972804 CNV duplication 23825009

Variation tolerance for OR1Q1 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1Q1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1Q1
Leiden Open Variation Database (LOVD)
OR1Q1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1Q1 Gene

Disorders for OR1Q1 Gene

Additional Disease Information for OR1Q1

No disorders were found for OR1Q1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1Q1 Gene

Publications for OR1Q1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3

Products for OR1Q1 Gene

Sources for OR1Q1 Gene