Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1P1 Gene

Aliases for OR1P1 Gene

  • Olfactory Receptor Family 1 Subfamily P Member 1 (Gene/Pseudogene) 2 3 5
  • OR17-208 2 3 4
  • Olfactory Receptor, Family 1, Subfamily P, Member 1 Pseudogene 2 3
  • OR1P1P 3 4
  • Olfactory Receptor, Family 1, Subfamily P, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor 17-208 4
  • Olfactory Receptor OR17-9 4
  • Olfactory Receptor 1P1 4
  • OR1P1 5

External Ids for OR1P1 Gene

Previous HGNC Symbols for OR1P1 Gene

  • OR1P1P

Previous GeneCards Identifiers for OR1P1 Gene

  • GC17M003004
  • GC17M003057
  • GC17M002949

Summaries for OR1P1 Gene

Entrez Gene Summary for OR1P1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR1P1 Gene

OR1P1 (Olfactory Receptor Family 1 Subfamily P Member 1 (Gene/Pseudogene)) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1G1.

UniProtKB/Swiss-Prot Summary for OR1P1 Gene

Additional gene information for OR1P1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1P1 Gene

Genomics for OR1P1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003167 Enhancer 0.6 Ensembl ENCODE 0.4 -12.9 -12919 1.2 PRDM1 IRF4 IKZF1 SPI1 IKZF2 OR1A2 OR1E2 HSALNG0113951 LOC100288728 OR1P1 OR1G1
GH17J003156 Enhancer 0.3 Ensembl 0.7 -2.1 -2119 2 ZNF680 OR1A2 OR1E2 ATP2A3 OR1P1 HSALNG0113951 LOC100288728 OR1G1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1P1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for OR1P1 Gene

Latest Assembly
chr17:3,153,889-3,154,882
(GRCh38/hg38)
Size:
994 bases
Orientation:
Minus strand

Previous Assembly
chr17:3,057,184-3,058,176
(GRCh37/hg19 by Entrez Gene)
Size:
993 bases
Orientation:
Minus strand

chr17:3,057,183-3,058,176
(GRCh37/hg19 by Ensembl)
Size:
994 bases
Orientation:
Minus strand

Genomic View for OR1P1 Gene

Genes around OR1P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1P1 Gene

Proteins for OR1P1 Gene

  • Protein details for OR1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH06-OR1P1_HUMAN
    Recommended name:
    Olfactory receptor 1P1
    Protein Accession:
    Q8NH06

    Protein attributes for OR1P1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36638 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1P1 Gene

Post-translational modifications for OR1P1 Gene

  • Glycosylation at Asn19

Other Protein References for OR1P1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for OR1P1 Gene

Domains & Families for OR1P1 Gene

Gene Families for OR1P1 Gene

Protein Domains for OR1P1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1P1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR17-9 (OR1P1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH06

UniProtKB/Swiss-Prot:

OR1P1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1P1: view

Function for OR1P1 Gene

Molecular function for OR1P1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1P1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1P1 Gene

Localization for OR1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1P1 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1P1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR1P1 Gene

Pathways & Interactions for OR1P1 Gene

PathCards logo

SuperPathways for OR1P1 Gene

genes like me logo Genes that share pathways with OR1P1: view

Pathways by source for OR1P1 Gene

Gene Ontology (GO) - Biological Process for OR1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1P1: view

No data available for Interacting Proteins and SIGNOR curated interactions for OR1P1 Gene

Drugs & Compounds for OR1P1 Gene

No Compound Related Data Available

Transcripts for OR1P1 Gene

mRNA/cDNA for OR1P1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1P1 Gene

No ASD Table

Relevant External Links for OR1P1 Gene

GeneLoc Exon Structure for
OR1P1

Expression for OR1P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1P1 Gene

genes like me logo Genes that share expression patterns with OR1P1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1P1 Gene

Orthologs for OR1P1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR1P1 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Or1p1 45 Olfr59
  • chr11:74,288,648-74,289,616
Or1p1b 45 Olfr404
  • chr11:74,239,566-74,240,447
Or1p1c 45 Olfr406
  • chr11:74,269,391-74,270,359
Or1p4-ps 45 Olfr409-ps1
  • chr11:74,317,027-74,317,994
Species where no ortholog for OR1P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1P1 Gene

ENSEMBL:
Gene Tree for OR1P1 (if available)
TreeFam:
Gene Tree for OR1P1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR1P1

Paralogs for OR1P1 Gene

(452) SIMAP similar genes for OR1P1 Gene using alignment to 1 proteins:

  • OR1P1_HUMAN
genes like me logo Genes that share paralogs with OR1P1: view

Variants for OR1P1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR1P1 Gene

OR1P1_HUMAN-Q8NH06
A stop codon in the gene coding for this protein at position Ala-185 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Additional Variant Information for OR1P1 Gene

Human Gene Mutation Database (HGMD)
OR1P1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1P1
Leiden Open Variation Database (LOVD)
OR1P1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR1P1 Gene

Disorders for OR1P1 Gene

No disorders were found for OR1P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR1P1 Gene

Publications for OR1P1 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 2 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

Products for OR1P1 Gene

Sources for OR1P1 Gene