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Aliases for OR1N2 Gene

Aliases for OR1N2 Gene

  • Olfactory Receptor Family 1 Subfamily N Member 2 2 3 5
  • Olfactory Receptor OR9-23 3 4
  • Olfactory Receptor, Family 1, Subfamily N, Member 2 2
  • Olfactory Receptor 1N2 3
  • OR9-23 3

External Ids for OR1N2 Gene

Previous GeneCards Identifiers for OR1N2 Gene

  • GC09U990174
  • GC09P120692
  • GC09P122397
  • GC09P124355
  • GC09P125315

Summaries for OR1N2 Gene

Entrez Gene Summary for OR1N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1N2 Gene

OR1N2 (Olfactory Receptor Family 1 Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1N1.

UniProtKB/Swiss-Prot for OR1N2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1N2 Gene

Additional gene information for OR1N2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1N2 Gene

Genomics for OR1N2 Gene

GeneHancer (GH) Regulatory Elements for OR1N2 Gene

Promoters and enhancers for OR1N2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122580 Enhancer 0.8 ENCODE 10.9 +27.4 27425 0.2 TAF9B CHAMP1 FOS GATAD2B ZEB2 ZNF592 SP1 NFIC MAFF GMEB1 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1Q1 OR1H1P OR1L8
GH09J122393 Enhancer 0.8 Ensembl ENCODE 8.9 -158.7 -158739 2.7 FOSL1 ATF4 STAT1 JUND PKNOX1 IKZF1 CEBPB FOS PTGS1 OR1K1 OR1Q1 OR1N2 ENSG00000233616 ENSG00000269970
GH09J122499 Enhancer 0.6 ENCODE 9.8 -54.0 -54035 0.1 CTCF PKNOX1 TFAP4 ZNF654 FOXA2 TRIM22 MAX REST RAD21 FOXA1 PIR39690 OR1J4 OR1N1 ENSG00000231465 OR1N2 OR5C1 OR1J1 OR1J2
GH09J122766 Enhancer 0.2 FANTOM5 15.9 +213.9 213893 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
GH09J122355 Enhancer 0.2 FANTOM5 14.9 -197.4 -197357 0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1N2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1N2 gene promoter:
  • AREB6
  • MIF-1
  • p53
  • NF-1/L
  • NF-1
  • c-Myb
  • Ik-1
  • LCR-F1
  • Evi-1
  • En-1

Genomic Locations for OR1N2 Gene

Genomic Locations for OR1N2 Gene
1,103 bases
Plus strand
1,103 bases
Plus strand

Genomic View for OR1N2 Gene

Genes around OR1N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1N2 Gene

Proteins for OR1N2 Gene

  • Protein details for OR1N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1N2
    Protein Accession:
    Secondary Accessions:
    • A3KFM2
    • B2RNY4
    • Q6IF17
    • Q96RA3

    Protein attributes for OR1N2 Gene

    330 amino acids
    Molecular mass:
    36889 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM45738.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1N2 Gene

Post-translational modifications for OR1N2 Gene

  • Glycosylation at Asn22
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1N2 Gene

Domains & Families for OR1N2 Gene

Gene Families for OR1N2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1N2 Gene

Suggested Antigen Peptide Sequences for OR1N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1N2: view

Function for OR1N2 Gene

Molecular function for OR1N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1N2: view
genes like me logo Genes that share phenotypes with OR1N2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1N2 Gene

Localization for OR1N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1N2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1N2 Gene

Pathways & Interactions for OR1N2 Gene

genes like me logo Genes that share pathways with OR1N2: view

Pathways by source for OR1N2 Gene

Gene Ontology (GO) - Biological Process for OR1N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1N2: view

No data available for SIGNOR curated interactions for OR1N2 Gene

Drugs & Compounds for OR1N2 Gene

No Compound Related Data Available

Transcripts for OR1N2 Gene

mRNA/cDNA for OR1N2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1N2 Gene

Olfactory receptor, family 1, subfamily N, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1N2 Gene

No ASD Table

Relevant External Links for OR1N2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1N2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1N2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1N2 Gene:


SOURCE GeneReport for Unigene cluster for OR1N2 Gene:

genes like me logo Genes that share expression patterns with OR1N2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1N2 Gene

Orthologs for OR1N2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1N2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473043 33
  • 98.89 (n)
OR1N2 34
  • 98 (a)
(Bos Taurus)
Mammalia LOC510570 33
  • 88.71 (n)
OR1N2 34
  • 58 (a)
(Mus musculus)
Mammalia Or1n2 51 Olfr354 16 34 33
  • 86.08 (n)
Or1ak2 51 Olfr356
  • chr2:36,937,121-36,938,065
(Rattus norvegicus)
Mammalia Olr417 33
  • 85.13 (n)
(Monodelphis domestica)
Mammalia OPOR49 34
  • 67 (a)
(Canis familiaris)
Mammalia OR08C09 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia OR1N2 34
  • 57 (a)
Species where no ortholog for OR1N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1N2 Gene

Gene Tree for OR1N2 (if available)
Gene Tree for OR1N2 (if available)
Evolutionary constrained regions (ECRs) for OR1N2: view image

Paralogs for OR1N2 Gene

Paralogs for OR1N2 Gene

(453) SIMAP similar genes for OR1N2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1N2: view

Variants for OR1N2 Gene

Sequence variations from dbSNP and Humsavar for OR1N2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000571140 -- 122,552,462(+) A/C upstream_transcript_variant
rs1002929690 -- 122,552,392(+) C/T upstream_transcript_variant
rs1003266973 -- 122,551,190(+) A/G upstream_transcript_variant
rs1006372151 -- 122,551,702(+) G/C upstream_transcript_variant
rs1007222699 -- 122,554,587(+) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1N2 Gene

Variant ID Type Subtype PubMed ID
esv22700 CNV loss 19812545
esv2659552 CNV deletion 23128226
esv3891726 CNV loss 25118596
nsv1039785 CNV gain 25217958

Variation tolerance for OR1N2 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1N2 Gene

Disorders for OR1N2 Gene

Additional Disease Information for OR1N2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR1N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1N2 Gene

Publications for OR1N2 Gene

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 44 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OR1N2 Gene

Sources for OR1N2 Gene

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