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Aliases for OR1N1 Gene

Aliases for OR1N1 Gene

  • Olfactory Receptor Family 1 Subfamily N Member 1 2 3 5
  • Olfactory Receptor OR9-22 3 4
  • Olfactory Receptor 1-26 3 4
  • Olfactory Receptor 1N3 3 4
  • OR1-26 3 4
  • OR1N3 3 4
  • Olfactory Receptor, Family 1, Subfamily N, Member 3 3
  • Olfactory Receptor, Family 1, Subfamily N, Member 1 2
  • Olfactory Receptor 1N1 3
  • OR9-22 3

External Ids for OR1N1 Gene

Previous HGNC Symbols for OR1N1 Gene

  • OR1N3

Previous GeneCards Identifiers for OR1N1 Gene

  • GC01U990262
  • GC09M120664
  • GC09M122368
  • GC09M124328
  • GC09M125288

Summaries for OR1N1 Gene

Entrez Gene Summary for OR1N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1N1 Gene

OR1N1 (Olfactory Receptor Family 1 Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR1N2.

UniProtKB/Swiss-Prot for OR1N1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1N1 Gene

Additional gene information for OR1N1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1N1 Gene

Genomics for OR1N1 Gene

GeneHancer (GH) Regulatory Elements for OR1N1 Gene

Promoters and enhancers for OR1N1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122463 Enhancer 1.1 Ensembl ENCODE 10.6 +62.5 62489 1.9 PKNOX1 SMAD1 ARID4B ZNF2 BRCA1 YY1 ARID2 ZNF143 ATF7 DEK OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 RBM18 MRRF TTLL11 ENSG00000231465
GH09J122580 Enhancer 0.8 ENCODE 10.5 -53.2 -53241 0.2 TAF9B CHAMP1 FOS GATAD2B ZEB2 ZNF592 SP1 NFIC MAFF GMEB1 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1Q1 OR1H1P OR1L8
GH09J122499 Enhancer 0.6 ENCODE 10.8 +28.2 28219 0.1 CTCF PKNOX1 TFAP4 ZNF654 FOXA2 TRIM22 MAX REST RAD21 FOXA1 PIR39690 OR1J4 OR1N1 ENSG00000231465 OR1N2 OR5C1 OR1J1 OR1J2
GH09J122057 Enhancer 0.4 FANTOM5 dbSUPER 4.8 +470.0 470012 0.1 TTLL11 OR1N1 OR1N2 OR1J4 MRRF OR1J2 LHX6 DAB2IP TTLL11-IT1
GH09J122355 Enhancer 0.2 FANTOM5 4.8 +171.5 171541 0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1N1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1N1 gene promoter:
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • C/EBPalpha
  • Nkx3-1 v3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v4
  • AML1a

Genomic Locations for OR1N1 Gene

Genomic Locations for OR1N1 Gene
chr9:122,526,358-122,527,296
(GRCh38/hg38)
Size:
939 bases
Orientation:
Minus strand
chr9:125,288,637-125,289,572
(GRCh37/hg19)
Size:
936 bases
Orientation:
Minus strand

Genomic View for OR1N1 Gene

Genes around OR1N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1N1 Gene

Proteins for OR1N1 Gene

  • Protein details for OR1N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS0-OR1N1_HUMAN
    Recommended name:
    Olfactory receptor 1N1
    Protein Accession:
    Q8NGS0
    Secondary Accessions:
    • A3KFM1
    • O43870
    • Q6IF16
    • Q96R93

    Protein attributes for OR1N1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1N1 Gene

Post-translational modifications for OR1N1 Gene

Other Protein References for OR1N1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1N1 Gene

Domains & Families for OR1N1 Gene

Gene Families for OR1N1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1N1 Gene

Suggested Antigen Peptide Sequences for OR1N1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGS0

UniProtKB/Swiss-Prot:

OR1N1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1N1: view

Function for OR1N1 Gene

Molecular function for OR1N1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily N,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1N1: view

Phenotypes for OR1N1 Gene

genes like me logo Genes that share phenotypes with OR1N1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1N1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1N1 Gene

Localization for OR1N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1N1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with OR1N1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1N1 Gene

Pathways & Interactions for OR1N1 Gene

genes like me logo Genes that share pathways with OR1N1: view

Pathways by source for OR1N1 Gene

1 BioSystems pathway for OR1N1 Gene
1 KEGG pathway for OR1N1 Gene

Interacting Proteins for OR1N1 Gene

Gene Ontology (GO) - Biological Process for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA,IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1N1: view

No data available for SIGNOR curated interactions for OR1N1 Gene

Drugs & Compounds for OR1N1 Gene

No Compound Related Data Available

Transcripts for OR1N1 Gene

mRNA/cDNA for OR1N1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1N1 Gene

Olfactory receptor, family 1, subfamily N, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1N1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1N1 Gene

No ASD Table

Relevant External Links for OR1N1 Gene

GeneLoc Exon Structure for
OR1N1
ECgene alternative splicing isoforms for
OR1N1

Expression for OR1N1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1N1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1N1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.9) and Testis (x6.0).

Protein differential expression in normal tissues from HIPED for OR1N1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR1N1 Gene



Protein tissue co-expression partners for OR1N1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1N1 Gene:

OR1N1

SOURCE GeneReport for Unigene cluster for OR1N1 Gene:

Hs.553604
genes like me logo Genes that share expression patterns with OR1N1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1N1 Gene

Orthologs for OR1N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1N1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473042 33
  • 99.46 (n)
OR1N1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR1N1 34 33
  • 85.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr414 33
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Or1n1 51 Olfr351 16 34 33
  • 81.72 (n)
Or1n1b 51 Olfr353 34
  • 79 (a)
OneToMany
Or1ah3 51 Olfr367
  • chr2:37,270,545-37,271,384
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR1P2 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
Species where no ortholog for OR1N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1N1 Gene

ENSEMBL:
Gene Tree for OR1N1 (if available)
TreeFam:
Gene Tree for OR1N1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1N1: view image

Paralogs for OR1N1 Gene

Paralogs for OR1N1 Gene

(451) SIMAP similar genes for OR1N1 Gene using alignment to 1 proteins:

  • OR1N1_HUMAN

Pseudogenes.org Pseudogenes for OR1N1 Gene

genes like me logo Genes that share paralogs with OR1N1: view

Variants for OR1N1 Gene

Sequence variations from dbSNP and Humsavar for OR1N1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
VAR_036208 A breast cancer sample p.Thr190Asn
rs201161748 uncertain-significance, not provided 122,526,441(-) G/A/T coding_sequence_variant, missense_variant
rs1000117179 -- 122,529,292(-) G/A upstream_transcript_variant
rs1001177590 -- 122,526,046(-) G/T downstream_transcript_variant
rs1002191338 -- 122,528,200(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1N1 Gene

Variant ID Type Subtype PubMed ID
esv3891726 CNV loss 25118596

Variation tolerance for OR1N1 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1N1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1N1 Gene

Disorders for OR1N1 Gene

Additional Disease Information for OR1N1

No disorders were found for OR1N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1N1 Gene

Publications for OR1N1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58

Products for OR1N1 Gene

Sources for OR1N1 Gene

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