Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1M1 Gene

Aliases for OR1M1 Gene

  • Olfactory Receptor Family 1 Subfamily M Member 1 2 3 5
  • OR19-6 2 3 4
  • Olfactory Receptor OR19-5 3 4
  • Olfactory Receptor 19-6 3 4
  • Olfactory Receptor 1M1 3 4
  • Olfactory Receptor, Family 1, Subfamily M, Member 1 2
  • OR19-5 3
  • OR1M1 5

External Ids for OR1M1 Gene

Previous GeneCards Identifiers for OR1M1 Gene

  • GC19U990197
  • GC19P009065
  • GC19P009203

Summaries for OR1M1 Gene

Entrez Gene Summary for OR1M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1M1 Gene

OR1M1 (Olfactory Receptor Family 1 Subfamily M Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1N1.

UniProtKB/Swiss-Prot Summary for OR1M1 Gene

Gene Wiki entry for OR1M1 Gene

Additional gene information for OR1M1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1M1 Gene

Genomics for OR1M1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1M1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009074 Enhancer 1.1 ENCODE CraniofacialAtlas 0.4 -11.5 -11524 1.7 PRDM10 ZNF629 LEF1 IKZF1 ZNF692 JUND ZIC2 PKNOX1 PATZ1 REST MUC16 ZNF414 LOC100419831 ZNF559 ZNF558 HNRNPM ZNF266 OR7G1 ZNF699 ZNF121
GH19J009079 Enhancer 0.8 Ensembl ENCODE 0.4 -7.1 -7097 0.8 CTCF JUND REST RAD21 ZNF444 ZNF316 USF1 SMC3 ZNF217 MAFG OR1M4P lnc-OR7G2-1 OR1M1 RF00017-2795 MUC16
GH19J009057 Enhancer 0.9 Ensembl ENCODE 0.3 -27.9 -27916 2.5 KDM1A ZIC2 PKNOX1 REST CEBPB SP1 CTBP1 ZNF623 MAFG EP300 RF00017-2795 MUC16 OR7D2 OR1M4P lnc-OR7G2-1 OR1M1
GH19J009069 Enhancer 0.6 Ensembl ENCODE 0.4 -16.7 -16690 1.7 TEAD4 ZNF341 SP1 EZH2 YY1 BACH1 MUC16 OR7G1 OR7G3 OR1M4P RF00017-2795 lnc-OR7G2-1 OR1M1
GH19J009052 Enhancer 0.8 ENCODE 0.3 -32.6 -32572 3.7 PRDM10 KDM1A FOXA1 RFX1 ZIC2 REST ARNT SP1 SMARCC1 ATF3 MUC16 ZNF177 ENSG00000267289 ENSG00000267273 ENSG00000200237 RF00017-2795 HG983750 TRQ-TTG8-1 OR1M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1M1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1M1

Top Transcription factor binding sites by QIAGEN in the OR1M1 gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for OR1M1 Gene

Genomic Locations for OR1M1 Gene
chr19:9,087,061-9,095,669
(GRCh38/hg38)
Size:
8,609 bases
Orientation:
Plus strand
chr19:9,203,855-9,204,889
(GRCh37/hg19)
Size:
1,035 bases
Orientation:
Plus strand

Genomic View for OR1M1 Gene

Genes around OR1M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1M1 Gene

Proteins for OR1M1 Gene

  • Protein details for OR1M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA1-OR1M1_HUMAN
    Recommended name:
    Olfactory receptor 1M1
    Protein Accession:
    Q8NGA1
    Secondary Accessions:
    • B9EHA6
    • Q6IFJ3
    • Q96R91

    Protein attributes for OR1M1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34840 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1M1 Gene

Post-translational modifications for OR1M1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1M1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1M1 Gene

Domains & Families for OR1M1 Gene

Gene Families for OR1M1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1M1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR1M1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-5 (OR1M1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGA1

UniProtKB/Swiss-Prot:

OR1M1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1M1: view

Function for OR1M1 Gene

Molecular function for OR1M1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily M,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1M1 Gene

Gene Ontology (GO) - Molecular Function for OR1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1M1: view
genes like me logo Genes that share phenotypes with OR1M1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1M1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1M1 Gene

Localization for OR1M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1M1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1M1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OR1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1M1 Gene

Pathways & Interactions for OR1M1 Gene

genes like me logo Genes that share pathways with OR1M1: view

Pathways by source for OR1M1 Gene

Interacting Proteins for OR1M1 Gene

Gene Ontology (GO) - Biological Process for OR1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1M1: view

No data available for SIGNOR curated interactions for OR1M1 Gene

Drugs & Compounds for OR1M1 Gene

No Compound Related Data Available

Transcripts for OR1M1 Gene

mRNA/cDNA for OR1M1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1M1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1M1 Gene

No ASD Table

Relevant External Links for OR1M1 Gene

GeneLoc Exon Structure for
OR1M1

Expression for OR1M1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1M1 Gene

Protein differential expression in normal tissues from HIPED for OR1M1 Gene

This gene is overexpressed in Oral epithelium (8.6), Bone marrow stromal cell (8.5), Retina (8.3), and Placenta (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR1M1 Gene



Protein tissue co-expression partners for OR1M1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1M1

SOURCE GeneReport for Unigene cluster for OR1M1 Gene:

Hs.553577
genes like me logo Genes that share expression patterns with OR1M1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1M1 Gene

Orthologs for OR1M1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1M1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR08C10 31
  • 87 (a)
OneToMany
OR1M1 30
  • 85.84 (n)
OR08F07 31
  • 85 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC513175 30
  • 85.09 (n)
OR1M1 31
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or1m1 46 Olfr24 30 17 31
  • 83.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1121 30
  • 82.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 77 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
Species where no ortholog for OR1M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1M1 Gene

ENSEMBL:
Gene Tree for OR1M1 (if available)
TreeFam:
Gene Tree for OR1M1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1M1: view image

Paralogs for OR1M1 Gene

(455) SIMAP similar genes for OR1M1 Gene using alignment to 1 proteins:

  • OR1M1_HUMAN

Pseudogenes.org Pseudogenes for OR1M1 Gene

genes like me logo Genes that share paralogs with OR1M1: view

Variants for OR1M1 Gene

Additional dbSNP identifiers (rs#s) for OR1M1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR1M1 Gene

Variant ID Type Subtype PubMed ID
esv2762024 CNV gain 21179565
nsv1056401 CNV gain 25217958
nsv509720 CNV insertion 20534489

Variation tolerance for OR1M1 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1M1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1M1 Gene

Disorders for OR1M1 Gene

No disorders were found for OR1M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1M1 Gene

Publications for OR1M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR1M1 Gene

Sources for OR1M1 Gene