Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1L8 Gene

Aliases for OR1L8 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 8 2 3 5
  • Olfactory Receptor OR9-24 3 4
  • Olfactory Receptor 1L8 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 8 2
  • OR9-24 3
  • OR1L8 5

External Ids for OR1L8 Gene

Previous GeneCards Identifiers for OR1L8 Gene

  • GC09U990175
  • GC09M120706
  • GC09M122409
  • GC09M124369
  • GC09M125329

Summaries for OR1L8 Gene

Entrez Gene Summary for OR1L8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L8 Gene

OR1L8 (Olfactory Receptor Family 1 Subfamily L Member 8) is a Protein Coding gene. Diseases associated with OR1L8 include Miles-Carpenter Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L1.

UniProtKB/Swiss-Prot Summary for OR1L8 Gene

Gene Wiki entry for OR1L8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1L8 Gene

Genomics for OR1L8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1L8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122355 Enhancer 0.7 FANTOM5 Ensembl 39.2 +227.9 227883 3 CTCF ZNF652 RAD21 ZNF143 IKZF1 ZNF444 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 ENSG00000233616
GH09J122766 Enhancer 0.2 FANTOM5 12.5 -183.6 -183621 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
GH09J122551 Enhancer 0.3 Ensembl 5.6 +31.9 31883 0.6 EZH2 OR1N2 OR1N1 OR1J4 OR1L8 piR-48950-218 HSALNG0074246 OR1J2 ENSG00000234156
GH09J122562 Enhancer 0.2 Ensembl 8.2 +21.0 20983 0.8 OR1N1 OR1J4 OR1J2 OR1L8 OR1N2 HSALNG0074246 ENSG00000234156
GH09J122580 Enhancer 1 Ensembl ENCODE 0.7 +2.9 2883 1 NCOR1 JUND ZNF592 NFIC EP300 TAF9B TAL1 ELF1 ZNF316 NFE2 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1H1P OR1J1 HSALNG0074246 OR1L8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1L8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1L8

Top Transcription factor binding sites by QIAGEN in the OR1L8 gene promoter:
  • HSF2
  • LCR-F1
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4

Genomic Locations for OR1L8 Gene

Latest Assembly
chr9:122,546,009-122,583,384
(GRCh38/hg38)
Size:
37,376 bases
Orientation:
Minus strand

Previous Assembly
chr9:125,329,827-125,330,756
(GRCh37/hg19 by Entrez Gene)
Size:
930 bases
Orientation:
Minus strand

chr9:125,329,778-125,330,838
(GRCh37/hg19 by Ensembl)
Size:
1,061 bases
Orientation:
Minus strand

Genomic View for OR1L8 Gene

Genes around OR1L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L8 Gene

Proteins for OR1L8 Gene

  • Protein details for OR1L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR8-OR1L8_HUMAN
    Recommended name:
    Olfactory receptor 1L8
    Protein Accession:
    Q8NGR8
    Secondary Accessions:
    • A3KFM3
    • B9EIR6
    • Q6IF15
    • Q96R79

    Protein attributes for OR1L8 Gene

    Size:
    309 amino acids
    Molecular mass:
    35083 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L8 Gene

Post-translational modifications for OR1L8 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1L8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L8 Gene

Domains & Families for OR1L8 Gene

Gene Families for OR1L8 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1L8 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1L8 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-24 (OR1L8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGR8

UniProtKB/Swiss-Prot:

OR1L8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L8: view

Function for OR1L8 Gene

Molecular function for OR1L8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR1L8: view
genes like me logo Genes that share phenotypes with OR1L8: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1L8

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1L8 Gene

Localization for OR1L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L8 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1L8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1L8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1L8 Gene

Pathways & Interactions for OR1L8 Gene

genes like me logo Genes that share pathways with OR1L8: view

Pathways by source for OR1L8 Gene

Interacting Proteins for OR1L8 Gene

Gene Ontology (GO) - Biological Process for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L8: view

No data available for SIGNOR curated interactions for OR1L8 Gene

Drugs & Compounds for OR1L8 Gene

No Compound Related Data Available

Transcripts for OR1L8 Gene

mRNA/cDNA for OR1L8 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1L8

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L8 Gene

No ASD Table

Relevant External Links for OR1L8 Gene

GeneLoc Exon Structure for
OR1L8

Expression for OR1L8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1L8 Gene

Protein differential expression in normal tissues from HIPED for OR1L8 Gene

This gene is overexpressed in Breast (37.3), Ovary (12.7), Adipocyte (12.5), and Salivary gland (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR1L8 Gene



Protein tissue co-expression partners for OR1L8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1L8

SOURCE GeneReport for Unigene cluster for OR1L8 Gene:

Hs.632695
genes like me logo Genes that share expression patterns with OR1L8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1L8 Gene

Orthologs for OR1L8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473044 29
  • 97.95 (n)
OR1L8 30
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC787415 29
  • 87.4 (n)
-- 30
  • 83 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
-- 30
  • 78 (a)
OneToMany
-- 30
  • 74 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100687372 29
  • 86.06 (n)
OR1L8 30
  • 80 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr418 29
  • 83.33 (n)
Mouse
(Mus musculus)
Mammalia Or1l8 45 Olfr355 29 16 30
  • 83.23 (n)
OneToOne
Species where no ortholog for OR1L8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1L8 Gene

ENSEMBL:
Gene Tree for OR1L8 (if available)
TreeFam:
Gene Tree for OR1L8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1L8: view image
Alliance of Genome Resources:
Additional Orthologs for OR1L8

Paralogs for OR1L8 Gene

(451) SIMAP similar genes for OR1L8 Gene using alignment to 1 proteins:

  • OR1L8_HUMAN
genes like me logo Genes that share paralogs with OR1L8: view

Variants for OR1L8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1L8 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs114238765 Benign: not provided 122,553,584(-) C/T
NM_001004457.2(OR1N2):c.373C>T (p.Arg125Cys)
MISSENSE
rs10739614 -- p.Arg211Pro
rs10985704 -- p.Thr27Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1L8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1L8 Gene

Variant ID Type Subtype PubMed ID
esv2659552 CNV deletion 23128226
nsv1039785 CNV gain 25217958
nsv1052657 CNV gain 25217958
nsv1054800 CNV loss 25217958

Variation tolerance for OR1L8 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1L8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1L8
Leiden Open Variation Database (LOVD)
OR1L8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L8 Gene

Disorders for OR1L8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR1L8 Gene - From: COP

Disorder Aliases PubMed IDs
miles-carpenter syndrome
  • mcs
- elite association - COSMIC cancer census association via MalaCards
Search OR1L8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR1L8

genes like me logo Genes that share disorders with OR1L8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1L8 Gene

Publications for OR1L8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. (PMID: 17434096) Matarín M … Meschia JF (The Lancet. Neurology 2007) 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR1L8 Gene

Sources for OR1L8 Gene