Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1L6 Gene

Aliases for OR1L6 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 6 2 3 5
  • Olfactory Receptor OR9-30 3 4
  • Olfactory Receptor 1L6 3 4
  • Olfactory Receptor 1L7 3 4
  • OR1L7 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 6 2
  • Olfactory Receptor, Family 1, Subfamily L, Member 7 3
  • OR9-30 3
  • OR1K1 3
  • OR1L6 5
  • HG16 3

External Ids for OR1L6 Gene

Previous HGNC Symbols for OR1L6 Gene

  • OR1L7

Previous GeneCards Identifiers for OR1L6 Gene

  • GC09U990113
  • GC09P120889
  • GC09P122591
  • GC09P124551
  • GC09P125512

Summaries for OR1L6 Gene

Entrez Gene Summary for OR1L6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L6 Gene

OR1L6 (Olfactory Receptor Family 1 Subfamily L Member 6) is a Protein Coding gene. Diseases associated with OR1L6 include Alternating Hemiplegia Of Childhood and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L4.

UniProtKB/Swiss-Prot Summary for OR1L6 Gene

Gene Wiki entry for OR1L6 Gene

Additional gene information for OR1L6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1L6 Gene

Genomics for OR1L6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1L6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122355 Enhancer 0.7 FANTOM5 Ensembl 4.9 -386.8 -386802 3 CTCF ZNF444 ZNF143 IKZF1 RAD21 ZNF652 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 ENSG00000233616
GH09J123239 Enhancer 0.6 FANTOM5 Ensembl 4.2 +497.1 497098 3.6 DPF2 ZNF202 FOS ZBTB33 NR3C1 ZBTB26 STRBP MRRF CRB2 ZBTB6 MIR600HG MIR600 RC3H2 OR1L6 GPR21
GH09J123172 Enhancer 0.3 FANTOM5 Ensembl 4.1 +429.6 429598 1.8 MIR600HG MIR600 STRBP OR1L4 OR1L6 GPR21
GH09J122766 Enhancer 0.2 FANTOM5 3.6 +24.7 24702 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
GH09J122777 Enhancer 0.8 Ensembl ENCODE 0.3 +36.4 36366 3 PRDM10 FOXA1 SMARCC1 CEBPB ESR1 CHD2 JUN JUND MAX DEK RABGAP1 lnc-OR5C1-1 piR-32810-140 OR5C1 OR1L6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1L6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1L6

Top Transcription factor binding sites by QIAGEN in the OR1L6 gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • E47
  • GATA-2
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1
  • TGIF

Genomic Locations for OR1L6 Gene

Genomic Locations for OR1L6 Gene
chr9:122,742,303-122,750,783
(GRCh38/hg38)
Size:
8,481 bases
Orientation:
Plus strand
chr9:125,512,019-125,513,062
(GRCh37/hg19)
Size:
1,044 bases
Orientation:
Plus strand

Genomic View for OR1L6 Gene

Genes around OR1L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L6 Gene

Proteins for OR1L6 Gene

  • Protein details for OR1L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR2-OR1L6_HUMAN
    Recommended name:
    Olfactory receptor 1L6
    Protein Accession:
    Q8NGR2
    Secondary Accessions:
    • Q6IFM8
    • Q96R80

    Protein attributes for OR1L6 Gene

    Size:
    347 amino acids
    Molecular mass:
    39515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05948.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for OR1L6 Gene

Post-translational modifications for OR1L6 Gene

  • Glycosylation at Asn41
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1L6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L6 Gene

Domains & Families for OR1L6 Gene

Gene Families for OR1L6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1L6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR1L6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-30 (OR1L6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGR2

UniProtKB/Swiss-Prot:

OR1L6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L6: view

Function for OR1L6 Gene

Molecular function for OR1L6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily L,member 6,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR1L6: view
genes like me logo Genes that share phenotypes with OR1L6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1L6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1L6 Gene

Localization for OR1L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1L6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1L6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1L6 Gene

Pathways & Interactions for OR1L6 Gene

genes like me logo Genes that share pathways with OR1L6: view

Pathways by source for OR1L6 Gene

Interacting Proteins for OR1L6 Gene

Gene Ontology (GO) - Biological Process for OR1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L6: view

No data available for SIGNOR curated interactions for OR1L6 Gene

Drugs & Compounds for OR1L6 Gene

No Compound Related Data Available

Transcripts for OR1L6 Gene

mRNA/cDNA for OR1L6 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1L6

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L6 Gene

No ASD Table

Relevant External Links for OR1L6 Gene

GeneLoc Exon Structure for
OR1L6

Expression for OR1L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1L6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1L6

SOURCE GeneReport for Unigene cluster for OR1L6 Gene:

Hs.553790
genes like me logo Genes that share expression patterns with OR1L6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1L6 Gene

Orthologs for OR1L6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L6 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR1L4 30
  • 87.06 (n)
-- 31
  • 87 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC504570 30
  • 86.34 (n)
-- 31
  • 83 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr364-ps1 31
  • 86 (a)
ManyToMany
Olfr365 30 17 31
  • 85.2 (n)
ManyToMany
Or1af1 46 Olfr366
  • chr2:37,219,491-37,220,417
Chimpanzee
(Pan troglodytes)
Mammalia OR1L6 31
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr428 30
  • 85.27 (n)
Oppossum
(Monodelphis domestica)
Mammalia OPOR56 31
  • 81 (a)
OneToMany
Species where no ortholog for OR1L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1L6 Gene

ENSEMBL:
Gene Tree for OR1L6 (if available)
TreeFam:
Gene Tree for OR1L6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1L6: view image

Paralogs for OR1L6 Gene

(453) SIMAP similar genes for OR1L6 Gene using alignment to 1 proteins:

  • OR1L6_HUMAN

Pseudogenes.org Pseudogenes for OR1L6 Gene

genes like me logo Genes that share paralogs with OR1L6: view

Variants for OR1L6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1L6 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10760252 - p.Gln59Lys
rs10818741 - p.Met259Ile
rs10985760 - p.Ile251Thr
rs4838012 - p.Cys186Tyr

Additional dbSNP identifiers (rs#s) for OR1L6 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR1L6 Gene

Variant ID Type Subtype PubMed ID
esv2472134 CNV deletion 19546169
esv2739015 CNV deletion 23290073
nsv972449 CNV duplication 23825009

Variation tolerance for OR1L6 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1L6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L6 Gene

Disorders for OR1L6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR1L6 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search OR1L6 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OR1L6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1L6 Gene

Publications for OR1L6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4

Products for OR1L6 Gene

Sources for OR1L6 Gene