Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1L3 Gene

Aliases for OR1L3 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 3 2 3 5
  • OR9-D 2 3 4
  • Olfactory Receptor OR9-28 3 4
  • Olfactory Receptor 1L3 3 4
  • Olfactory Receptor 9-D 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 3 2
  • OR9-28 3
  • OR1L3 5

External Ids for OR1L3 Gene

Previous GeneCards Identifiers for OR1L3 Gene

  • GC09U990115
  • GC09P122516
  • GC09P124477
  • GC09P125438

Summaries for OR1L3 Gene

Entrez Gene Summary for OR1L3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L3 Gene

OR1L3 (Olfactory Receptor Family 1 Subfamily L Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L1.

UniProtKB/Swiss-Prot Summary for OR1L3 Gene

Gene Wiki entry for OR1L3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1L3 Gene

Genomics for OR1L3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122374 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas 2.7 -298.4 -298430 4.2 IKZF1 ZNF600 NCOR1 ZNF592 CEBPA NFIC CEBPB MBD2 TBP ZNF341 ZBTB26 RC3H2 OR1K1 PTGS1 DAB2IP OR1L3 ENSG00000269970 lnc-OR1J1-2 OR1J2
GH09J123106 Enhancer 0.2 FANTOM5 4.4 +432.0 431986 0.1 RABGAP1 OR1L3 OR1K1 GPR21 piR-45880 piR-55985-205 STRBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1L3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1L3

Top Transcription factor binding sites by QIAGEN in the OR1L3 gene promoter:
  • aMEF-2
  • AML1a
  • ATF
  • ITF-2
  • MEF-2A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • RSRFC4
  • Tal-1beta

Genomic Locations for OR1L3 Gene

Latest Assembly
chr9:122,675,036-122,676,153
(GRCh38/hg38)
Size:
1,118 bases
Orientation:
Plus strand

Previous Assembly
chr9:125,437,409-125,438,383
(GRCh37/hg19 by Entrez Gene)
Size:
975 bases
Orientation:
Plus strand

chr9:125,437,315-125,438,432
(GRCh37/hg19 by Ensembl)
Size:
1,118 bases
Orientation:
Plus strand

Genomic View for OR1L3 Gene

Genes around OR1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L3 Gene

Proteins for OR1L3 Gene

  • Protein details for OR1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH93-OR1L3_HUMAN
    Recommended name:
    Olfactory receptor 1L3
    Protein Accession:
    Q8NH93
    Secondary Accessions:
    • B2RNF4
    • Q6IFN1

    Protein attributes for OR1L3 Gene

    Size:
    324 amino acids
    Molecular mass:
    36633 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L3 Gene

Post-translational modifications for OR1L3 Gene

  • Glycosylation at Asn5

Other Protein References for OR1L3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L3 Gene

Domains & Families for OR1L3 Gene

Gene Families for OR1L3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1L3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1L3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-28 (OR1L3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH93

UniProtKB/Swiss-Prot:

OR1L3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L3: view

Function for OR1L3 Gene

Molecular function for OR1L3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily L,member 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1L3 Gene

Gene Ontology (GO) - Molecular Function for OR1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with OR1L3: view

Phenotypes for OR1L3 Gene

genes like me logo Genes that share phenotypes with OR1L3: view

Animal Models for research

miRNA for OR1L3 Gene

miRTarBase miRNAs that target OR1L3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1L3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1L3 Gene

Localization for OR1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1L3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1L3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1L3 Gene

Pathways & Interactions for OR1L3 Gene

genes like me logo Genes that share pathways with OR1L3: view

Pathways by source for OR1L3 Gene

Gene Ontology (GO) - Biological Process for OR1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L3: view

No data available for SIGNOR curated interactions for OR1L3 Gene

Drugs & Compounds for OR1L3 Gene

No Compound Related Data Available

Transcripts for OR1L3 Gene

mRNA/cDNA for OR1L3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1L3

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L3 Gene

No ASD Table

Relevant External Links for OR1L3 Gene

GeneLoc Exon Structure for
OR1L3

Expression for OR1L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1L3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1L3

SOURCE GeneReport for Unigene cluster for OR1L3 Gene:

Hs.626839
genes like me logo Genes that share expression patterns with OR1L3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1L3 Gene

Orthologs for OR1L3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR1L3 29 30
  • 86.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OPOR48 30
  • 48 (a)
ManyToMany
Species where no ortholog for OR1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1L3 Gene

ENSEMBL:
Gene Tree for OR1L3 (if available)
TreeFam:
Gene Tree for OR1L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1L3: view image
Alliance of Genome Resources:
Additional Orthologs for OR1L3

Paralogs for OR1L3 Gene

(453) SIMAP similar genes for OR1L3 Gene using alignment to 1 proteins:

  • OR1L3_HUMAN
genes like me logo Genes that share paralogs with OR1L3: view

Variants for OR1L3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1L3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs12379744 -- p.Arg54Gly
rs16912096 -- p.Val106Ala
rs16912099 -- p.Asn121Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1L3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1L3 Gene

Variant ID Type Subtype PubMed ID
esv6464 OTHER inversion 19470904

Variation tolerance for OR1L3 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1L3
Leiden Open Variation Database (LOVD)
OR1L3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L3 Gene

Disorders for OR1L3 Gene

Additional Disease Information for OR1L3

No disorders were found for OR1L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1L3 Gene

Publications for OR1L3 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR1L3 Gene

Sources for OR1L3 Gene